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View article: #358 Improving and personalizing nephrology care with the use of outcome data: examples of national and regional initiatives in the Netherlands
#358 Improving and personalizing nephrology care with the use of outcome data: examples of national and regional initiatives in the Netherlands Open
Background and Aims Dutch nephrology care aims for a more sustainable way of using outcome data. The national Dutch nephrology quality system includes guideline development, the Nefrodata registry (since 1986), outcome data benchmarking, a…
View article: Cardiovascular Biomarkers in Nocturnal Hemodialysis and Their Association With Physical Performance
Cardiovascular Biomarkers in Nocturnal Hemodialysis and Their Association With Physical Performance Open
Introduction The cardiovascular biomarkers troponin T, N‐terminal pro‐B‐type natriuretic peptide, and fibroblast growth factor 23 are elevated in hemodialysis patients and associated with an increased cardiovascular mortality risk. Nocturn…
View article: #2851 Effects of dialysis on various microcirculatory beds in end-stage kidney disease (ESKD): a systematic review and meta-analysis
#2851 Effects of dialysis on various microcirculatory beds in end-stage kidney disease (ESKD): a systematic review and meta-analysis Open
Background and Aims Microcirculatory dysfunction is common in ESKD-patients and may play a pivotal role in their cardiovascular burden. Besides traditional and chronic-kidney-disease (CKD)-specific risk factors, dialysis itself might contr…
View article: Proton pump inhibitor induced hypomagnesemia and mortality: mediation analyses in the Diabetes Care System cohort
Proton pump inhibitor induced hypomagnesemia and mortality: mediation analyses in the Diabetes Care System cohort Open
Background: Chronic proton pump inhibitor (PPI) use and hypomagnesemia are common in people with type 2 diabetes (T2D), and both are associated with increased mortality and cardiovascular disease (CVD). Since PPI use can cause hypomagnesem…
View article: Nocturnal Hemodialysis Leads to Improvement in Physical Performance in Comparison with Conventional Hemodialysis
Nocturnal Hemodialysis Leads to Improvement in Physical Performance in Comparison with Conventional Hemodialysis Open
End-stage kidney disease patients treated with conventional hemodialysis (CHD) are known to have impaired physical performance and protein-energy wasting (PEW). Nocturnal hemodialysis (NHD) was shown to improve clinical outcomes, but the e…
View article: Comorbidity is not associated with dialysis modality choice in patients with end‐stage kidney disease
Comorbidity is not associated with dialysis modality choice in patients with end‐stage kidney disease Open
Aim Over the past years the proportion of home dialysis patients has decreased in the Netherlands. In addition, the home dialysis use varies significantly among centres. It is unclear whether this is the result of differences in comorbidit…
View article: Differences in hospitalisation between peritoneal dialysis and haemodialysis patients
Differences in hospitalisation between peritoneal dialysis and haemodialysis patients Open
Background Dialysis is associated with frequent hospitalisations. Studies comparing hospitalisations between peritoneal dialysis (PD) and haemodialysis (HD) report conflicting results and mostly analyse data of patients that remain on thei…
View article: Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease
Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease Open
Background Vascular calcification is a key process involved in cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Magnesium supplementation may counteract vascular calcification. In this study we aimed to…
View article: Dialysis withdrawal in The Netherlands between 2000 and 2019: time trends, risk factors and centre variation
Dialysis withdrawal in The Netherlands between 2000 and 2019: time trends, risk factors and centre variation Open
Background Dialysis withdrawal is a common cause of death in dialysis-dependent patients. This study aims to describe dialysis withdrawal practice in The Netherlands, focussing on time trends, risk factors and centre variation. Methods Dat…
View article: Trends in home dialysis use differ among age categories in past two decades: A Dutch registry study
Trends in home dialysis use differ among age categories in past two decades: A Dutch registry study Open
Background Although the number of patients with end‐stage kidney disease is growing, the number of patients who perform dialysis at home has decreased during the past two decades. The aim of this study was to explore time trends in the use…
View article: Conducting correlation analysis: important limitations and pitfalls
Conducting correlation analysis: important limitations and pitfalls Open
The correlation coefficient is a statistical measure often used in studies to show an association between variables or to look at the agreement between two methods. In this paper, we will discuss not only the basics of the correlation coef…
View article: The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis Open
Magnesium concentration is inversely associated with all-cause mortality and cardiovascular mortality and events. Therefore, increasing magnesium may improve risk in patients with chronic kidney disease. This meta-analysis forms a firm bas…
View article: Funnel plots of patient‐reported outcomes to evaluate health‐care quality: Basic principles, pitfalls and considerations
Funnel plots of patient‐reported outcomes to evaluate health‐care quality: Basic principles, pitfalls and considerations Open
A funnel plot is a graphical method to evaluate health‐care quality by comparing hospital performances on certain outcomes. So far, in nephrology, this method has been applied to clinical outcomes like mortality and complications. However,…
View article: Short-term effects of sevelamer-carbonate on fibroblast growth factor 23 and pulse wave velocity in patients with normophosphataemic chronic kidney disease Stage 3
Short-term effects of sevelamer-carbonate on fibroblast growth factor 23 and pulse wave velocity in patients with normophosphataemic chronic kidney disease Stage 3 Open
Background High concentrations of both phosphate and fibroblast growth factor 23 (FGF23) observed in chronic kidney disease (CKD) are associated with an increased risk of cardiovascular morbidity and mortality. Pulse wave velocity (PWV) is…
View article: Erythropoiesis-stimulating agents and cardiovascular events in patients with myelodysplastic syndrome and multiple myeloma
Erythropoiesis-stimulating agents and cardiovascular events in patients with myelodysplastic syndrome and multiple myeloma Open
ESA use was associated with stroke in MDS patients. Among MM patients, ESA treatment was associated with a higher risk of all cardiovascular events, although all CIs included equivalence.
View article: Long-term clinical parameters after switching to nocturnal haemodialysis: a Dutch propensity-score-matched cohort study comparing patients on nocturnal haemodialysis with patients on three-times-a-week haemodialysis/haemodiafiltration
Long-term clinical parameters after switching to nocturnal haemodialysis: a Dutch propensity-score-matched cohort study comparing patients on nocturnal haemodialysis with patients on three-times-a-week haemodialysis/haemodiafiltration Open
Objectives Nocturnal haemodialysis (NHD), characterised by 8-hour sessions ≥3 times a week, is known to improve clinical parameters in the short term compared with conventional-schedule haemodialysis (HD), generally 3×3.5–4 hours a week. W…
View article: Left ventricular geometric patterns in end‐stage kidney disease: Determinants and course over time
Left ventricular geometric patterns in end‐stage kidney disease: Determinants and course over time Open
Introduction : While concentric left ventricular hypertrophy (cLVH) predominates in non–dialysis‐dependent chronic kidney disease (CKD), eccentric left ventricular hypertrophy (eLVH) is most prevalent in dialysis‐dependent CKD stage 5 (CKD…
View article: Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis
Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis Open
Background: Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than i…
View article: Perceived Sodium Reduction Barriers Among Patients with Chronic Kidney Disease: Which Barriers Are Important and Which Patients Experience Barriers?
Perceived Sodium Reduction Barriers Among Patients with Chronic Kidney Disease: Which Barriers Are Important and Which Patients Experience Barriers? Open
Patients with CKD experience multiple important sodium reduction barriers and could benefit from support strategies that target various sodium reduction barriers and strengthen beliefs regarding self-efficacy and autonomy support. Addition…
View article: Cardiovascular events in anti-neutrophil cytoplasmic antibody-associated vasculitis: a meta-analysis of observational studies
Cardiovascular events in anti-neutrophil cytoplasmic antibody-associated vasculitis: a meta-analysis of observational studies Open
This meta-analysis of observational studies supports an increase in cardiovascular risk in patients with ANCA-associated vasculitis of ∼65%, similar to that found in other chronic inflammatory diseases. Hence, there is a clear need for act…