Tiziana Cervelli YOU? Author Swipe

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Special Issue: “Yeast as a Model System to Study Human Diseases” Open

Nicoletta Guaragnella, Belém Sampaio‐Marques, Tiziana Cervelli · 2025

Yeast is a well-known eukaryote that has been fundamental in the discovery of principles governing cellular life [...]

Functional Characterization of the Human BRCA1 ∆11 Splicing Isoforms in Yeast Open

Alvaro Galli, Francesca Bellè, Arcangelo Fargnoli, Maria A. Caligo, Tiziana Cervelli · 2024

BRCA1, a crucial tumor suppressor gene, has several splicing isoforms, including Δ9–11, Δ11, and Δ11q, which lack exon 11, coding for significant portions of the protein. These isoforms are naturally present in both normal and cancerous ce…

Identification of novel plant cysteine oxidase inhibitors from a yeast chemical genetic screen Open

Mikel Lavilla-Puerta, Rebecca Latter, Francesca Bellè, Tiziana Cervelli, Alvaro Galli , et al. · 2023

Effects of single and fractionated low-dose irradiation on vascular endothelial cells Open

Tiziana Cervelli, Daniele Panetta, Teresa Navarra, Maria Grazia Andreassi, Giuseppina Basta , et al. · 2023

This is the unformatted version of the accepted paper manuscript "Effects of single and fractionated low-dose irradiation on vascular endothelial cells" published on Atheroscllerosis 2014 Aug;235(2):510-8.doi: 10.1016/j.atherosclerosis.201…

Yeast and Virus-like Particles: A Perfect or Imperfect Couple? Open

Sara Brachelente, Alvaro Galli, Tiziana Cervelli · 2023

Virus-like particles (VLPs) comprise viral structural proteins that self-assemble to form a particle similar to the native virus capsid. Since their discovery, they have been employed mainly as vaccines to prevent viral infection because t…

PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation Open

Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi , et al. · 2023

Additional file 4 of PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation Open

Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi , et al. · 2023

Additional file 4. Table S2: The 87 cytoplasmic proteins identified by mass spectrometry.

Additional file 3 of PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation Open

Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi , et al. · 2023

Additional file 3. Table S1: Primers.

Additional file 5 of PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation Open

Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi , et al. · 2023

Additional file 5. Table S3: Reactome pathways to which the 51 selected RBPs belong, listed top to bottom according to increasing FDR values.

Additional file 6 of PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation Open

Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi , et al. · 2023

Additional file 6. Table S4: Binding affinity of the 20 mRBPs to the R8 fragment of X1 3’UTR, according to catRAPID omics v2.0 program.

Validation and Data-Integration of Yeast-Based Assays for Functional Classification of BRCA1 Missense Variants Open

Francesca Bellè, Alberto Mercatanti, Samuele Lodovichi, Caterina Congregati, Chiara Guglielmi , et al. · 2022

Germline mutations in the BRCA1 gene have been reported to increase the lifetime risk of developing breast and/or ovarian cancer (BOC). By new sequencing technologies, numerous variants of uncertain significance (VUS) are identified. It is…

<i>RAD52</i> influences the effect of <i>BRCA1/2</i> missense variants on homologous recombination and gene reversion in <i>Saccharomyces cerevisiae</i> Open

Samuele Lodovichi, Francesca Bellè, Alberto Mercatanti, Laura Spugnesi, Cristina Cozzani , et al. · 2022

The breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, are key players in the homologous recombination (HR) repair pathway and act as tumor suppressors by maintaining genome stability. The yeast Saccharomyces cerevisiae has n…

Yeast as a Tool to Understand the Significance of Human Disease-Associated Gene Variants Open

Tiziana Cervelli, Alvaro Galli · 2021

At present, the great challenge in human genetics is to provide significance to the growing amount of human disease-associated gene variants identified by next generation DNA sequencing technologies. Increasing evidences suggest that model…

Detection of Germline Variants in 450 Breast/Ovarian Cancer Families with a Multi-Gene Panel Including Coding and Regulatory Regions Open

Chiara Guglielmi, Rosa Scarpitta, Gaetana Gambino, Eleonora Conti, Francesca Bellè , et al. · 2021

With the progress of sequencing technologies, an ever-increasing number of variants of unknown functional and clinical significance (VUS) have been identified in both coding and non-coding regions of the main Breast Cancer (BC) predisposit…

Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach Open

Samuele Lodovichi, Tiziana Cervelli, Achille Pellicioli, Alvaro Galli · 2020

Alterations in DNA repair pathways are one of the main drivers of cancer insurgence. Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they rely on specific functional repair pathways to survive. Thanks to…

Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes Open

Tiziana Cervelli, Samuele Lodovichi, Francesca Bellè, Alvaro Galli · 2020

Technological advances are continuously revealing new genetic variants that are often difficult to interpret. As one of the most genetically tractable model organisms, yeast can have a central role in determining the consequences of human …

Computational analysis of data from a genome-wide screening identifies new <i>PARP1</i> functional interactors as potential therapeutic targets Open

Samuele Lodovichi, Alberto Mercatanti, Tiziana Cervelli, Alvaro Galli · 2019

Knowledge of interaction network between different proteins can be a useful tool in cancer therapy. To develop new therapeutic treatments, understanding how these proteins contribute to dysregulated cellular pathways is an important task. …

Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development Open

Luisa Maresca, Samuele Lodovichi, Alessandra Lorenzoni, Tiziana Cervelli, Rossella Di Monaco , et al. · 2018

In this study, we determined if BRCA1 partners involved in DNA double-strand break (DSB) and mismatch repair (MMR) may contribute to breast and ovarian cancer development. Taking advantage the functional conservation of DNA repair pathways…

CRIMEtoYHU: a new web tool to develop yeast-based functional assays for characterizing cancer-associated missense variants Open

Alberto Mercatanti, Samuele Lodovichi, Tiziana Cervelli, Alvaro Galli · 2017

Evaluation of the functional impact of cancer-associated missense variants is more difficult than for protein-truncating mutations and consequently standard guidelines for the interpretation of sequence variants have been recently proposed…

A New Natural Antioxidant Mixture Protects against Oxidative and DNA Damage in Endothelial Cell Exposed to Low‐Dose Irradiation Open

Tiziana Cervelli, Daniele Panetta, Teresa Navarra, S. Gadhiri, Piero Salvadori , et al. · 2017

Exposure to ionizing radiation during diagnostic procedures increases systemic oxidative stress and predisposes to higher risk of cancer and cardiovascular disease development. Many studies indicated that antioxidants protect against radia…

Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in<i>Saccharomyces cerevisiae</i>without altering its nuclear localization Open

Samuele Lodovichi, Martina Vitello, Tiziana Cervelli, Alvaro Galli · 2016

BRCA1 tumor suppressor gene is found mutated in familial breast and ovarian cancer. Most cancer related mutations were found located at the RING (Really Interesting New Gene) and at the BRCT (BRca1 C-Terminal) domain. However, 20 y after i…

MSH2 role in BRCA1-driven tumorigenesis: A preliminary study in yeast and in human tumors from BRCA1-VUS carriers Open

Luisa Maresca, Laura Spugnesi, Samuele Lodovichi, Cristina Cozzani, Antonio Giuseppe Naccarato , et al. · 2015

Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae Open

Alvaro Galli, C. Y. Chan, Liubov Parfenova, Tiziana Cervelli, R. H. Schiestl · 2015

Non-homologous end joining (NHEJ) directly joins two broken DNA ends without sequence homology. A distinct pathway called microhomology-mediated end joining (MMEJ) relies on a few base pairs of homology between the recombined DNA. The majo…

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