Explanipedia

Move by move towards mental health: A pilot study on chess as a therapeutic approach in adolescents with mental disorders Open

Sarah Gerhardt, Stefanie Hoier, A. SEEGER, Roland Schmidt, Larissa Weber , et al. · 2025

Background Mental disorders affect approximately 14% of adolescents worldwide, often leading to persistent cognitive and emotional difficulties and reduced health-related quality of life (HRQoL). Executive functions (EF)—including cognitiv…

A psychobiological resilience factor for mental health across the lifespan Open

Tianye Jia, Zi-Bin Yang, Shitong Xiang, Rui Zhai, Zheng Chen , et al. · 2025

Insights from 24-hour actigraphy using functional linear modeling in children with and without ADHD Open

Mirjam Ziegler, Pascal-M. Aggensteiner, Katja Becker, Manfred Döpfner, Julia Geißler , et al. · 2025

Sleep problems and alterations in circadian rhythmicity have been widely reported in attention-deficit/hyperactivity disorder (ADHD) patients, but studies covering the full 24h-motor-activity patterns to explore whole-day activity cycles a…

Suchterkrankungen und Elternschaft – Belastungen und Versorgung Open

Anne Koopmann, Andreas Hoell, Anita Schick, Andreas Meyer-Lindenberg, Falk Kiefer , et al. · 2025

Zusammenfassung: Zielsetzung: In Deutschland leben 1.5 bis 2.75 Millionen Kinder in suchtbelasteten Familien und 3.8 Millionen bei Eltern mit anderen psychischen Erkrankungen. Es ist wenig bekannt zu Unterschieden zwischen beiden Elterngru…

Linking genetics to behavior: from glutamatergic genetic variation via amygdala morphology and fear recognition to youth’s callous-unemotional traits and reactive-proactive aggression Open

Renee Kleine Deters, I. Hyun Ruisch, Jilly Naaijen, Pascal-M. Aggensteiner, Tobias Banaschewski , et al. · 2025

Our results suggest that 1) glutaminergic genetic variation is associated with CU traits, 2) glutamatergic genetic variation is associated with amygdala volume and fear recognition, and 3) indirectly with CU traits through fear recognition…

Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis Open

Xiao Chang, Tianye Jia, Zening Fu, Shitong Xiang, Yunman Xia , et al. · 2025

Cognitive processing in humans relies on regional brain activity and large-scale, whole-brain network interactions which evolve in a time-dependent manner. Traditional task-based neuroimaging analysis does not sufficiently consider this te…

Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth Open

Annie Cheng, Sarah Lichenstein, Bader Chaarani, Qinghao Liang, Marzieh Babaeianjelodar , et al. · 2025

Increases in impulsivity and negative affect (e.g., neuroticism) are common during adolescence and are both associated with risk for alcohol-use initiation and other risk behaviors. Whole-brain functional connectivity approaches-when coupl…

Cross-Cultural Consortium on Irritability (C3I): An International Network for Research on Cultural Similarities and Differences in Irritability Open

Wan‐Ling Tseng, Nellia Bellaert, Tami D. Benton, Melissa A. Brotman, Spencer C. Evans , et al. · 2025

Longitudinal associations of structural and functional brain connectivity with dimensions of psychopathology in adolescence Open

Lucy Vanes, Divyangana Rakesh, Tobias Banaschewski, Arun Bodke, Sylvane Desrivières , et al. · 2025

These findings highlight the dynamic interplay between brain connectivity development and psychopathology in adolescence, with potential implications for identifying neural markers of risk and resilience during sensitive windows of develop…

Mapping the coupling between tract reachability and cortical geometry of the human brain Open

Deying Li, Andrew Zalesky, Yufan Wang, Haiyan Wang, Liang Ma , et al. · 2025

The study of cortical geometry and connectivity is prevalent in human brain research. However, these two aspects of brain structure are usually examined separately, leaving the essential connections between the brain's folding patterns and…

Shared and Distinct Alterations in Brain Structure of Youth With Internalizing or Externalizing Disorders: Findings From the ENIGMA Antisocial Behavior, ADHD, Major Depressive Disorder, and Anxiety Working Groups Open

Sophie Townend, Marlene Staginnus, Yidian Gao, Nina Alexander, Volker Arolt , et al. · 2025

Sex-Specific Differences in Antidepressant and Antipsychotic Treatment Outcomes and Serum Levels in Children and Adolescents Open

Maike Scherf‐Clavel, Stefanie Fekete, Manfred Gerlach, Christoph U. Correll, Paul L. Plener , et al. · 2025

Introduction: Sex-specific differences in psychopharmacological treatment have gained increasing attention in adults, with studies showing that women often have higher serum concentrations of psychotropic drugs due to biological difference…

Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics Open

Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr , et al. · 2025

Imaging transcriptomics has become a power tool for linking imaging-derived phenotypes (IDPs) to genomic mechanisms. Yet, its potential for guiding CNS drug discovery remains underexplored. Here, utilizing spatially-dense representations o…

Genetic risk-dependent brain markers of resilience to childhood Trauma Open

Lu Han, Edmund T. Rolls, H. MEI LIU, Dan J. Stein, Barbara J. Sahakian , et al. · 2025

Resilience to developing emotional disorders is critical for adolescent mental health, especially following childhood trauma. Yet, brain markers of resilience remain poorly understood. By analyzing brain responses to angry faces in a large…

White matter microstructure of the cingulum bundle and the uncinate fasciculus in primary and secondary callous-unemotional traits Open

Luisa Schalk, Arjun Sethi, Michael Craig, Itziar Flamarique, Jilly Naaijen , et al. · 2025

Parsing Autism Heterogeneity: Transcriptomic Subgrouping of Imaging-Derived Phenotypes in Autism Open

Johanna Leyhausen, Caroline Gurr, Lisa M. Berg, Hanna Seelemeyer, Bassem Hermila , et al. · 2025

Autistic individuals can be subgrouped based on the transcriptomic signatures associated with their neuroanatomical fingerprints, which reveal subgroups that show differences in clinical measures. The study presents an analytical framework…

Efficacy of a mobile-based self-directed parent management training for parents of children with attention-deficit/hyperactivity disorder with or without oppositional defiant disorder– a randomized controlled trial Open

Manfred Döpfner, Anja Görtz‐Dorten, Alexander Häge, F Handermann, L Sulprizio , et al. · 2025

Preliminary empirical evidence supports the efficacy of digital parent management training (d-PMT) in the treatment of externalizing behavior problems in children. This study investigated the efficacy of a mobile-based self-directed d-PMT …

Lifespan investigation of brain volumetric changes associated with substance use disorders Open

Xiaolei Lin, Runye Shi, Shitong Xiang, Dag Alnæs, Di Chen , et al. · 2025

Medication Nonadherence in Children and Adolescents with ADHD Open

Konstantin Mechler, Tobias Banaschewski, Tobias Hellenschmidt, Christoph U. Correll, Frank Theisen , et al. · 2025

Objective: Attention-deficit/hyperactivity disorder (ADHD) affects 6–10 % of children and adolescents worldwide. While psychopharmacological treatments effectively reduce symptoms, incomplete adherence is common, diminishing their effectiv…

Framework for Brain-Derived Dimensions of Psychopathology Open

Tristram A. Lett, Nilakshi Vaidya, Tianye Jia, Elli Polemiti, Tobias Banaschewski , et al. · 2025

Importance Psychiatric diagnoses are not defined by neurobiological measures hindering the development of therapies targeting mechanisms underlying mental illness. Research confined to diagnostic boundaries yields heterogeneous biological …

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling Open

Amin Saberi, Kevin J. Wischnewski, Kyesam Jung, Leon D. Lotter, H. Lina Schaare , et al. · 2025

The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual’s lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has p…

Lifespan investigation of brain volumetric changes associated with substance use disorders Open

Runye Shi, Shitong Xiang, Dag Alnæs, Di Chen, Zheng Chen , et al. · 2025

Substance use disorder (SUD) stands as a critical public health concern, contributing to substantial morbidity, mortality and societal costs. The effects of SUD on structural brain changes have been well documented. However, the neural mec…

Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology Open

Ana Isabel Silva, Ida E. Sønderby, George Kirov, Abdel Abdellaoui, Ingrid Agartz , et al. · 2025

Our findings link global and regional cortical morphometric features with CNV penetrance, providing new insights into neurobiological mechanisms of genetic risk for schizophrenia and other developmental disorders.

Neurophysiological Alterations during Sensory Processing in Autism - A Meta-Analysis Open

Anjuli Ghosh, Natalia Nasarre Nacenta, Sarah Baumeister, Nathalie Holz, Tobias Banaschewski , et al. · 2025

Objective While sensory processing alterations in autism are well-documented, the neurophysiological correlates remain unclear. This meta-analysis examined differences in early event-related potentials (ERP) and event-related fields (ERF) …

The long-term correlates of developmental stress on whole-brain functional connectivity during emotion regulation Open

Seda Sacu, Andrea Hermann, Tobias Banaschewski, Martin Fungisai Gerchen, Nathalie Holz · 2025

Early life stress is associated with alterations in brain function and connectivity during affective processing, especially in the fronto-limbic pathway. However, most of the previous studies were limited to a small set of priori-selected …

Estimating differing causal roles of glutamate and GABA genes on brain and behavior in autism Open

Viola Hollestein, Tom Claassen, Jilly Naaijen, Geert Poelmans, I. Hyun Ruisch , et al. · 2025

The excitatory/inhibitory (E/I) imbalance theory suggests that excitatory and inhibitory alterations underlies autism characteristics. However, genetic underpinnings of this imbalance and its impact on brain function and behavior remains u…

Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry Open

Rui Zhai, Yechen Hu, Liping Zheng, Shitong Xiang, Chao Xie , et al. · 2025

Task-fMRI analyses typically focus on localized activation contrasts between stimuli, neglecting the brain’s dynamic hierarchy. We introduce Brain Diffusion Transformer (Brain-DiT), a deep generative model capturing recurrent processing un…

A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders Open

Charlotte Bowers Caswell, Niki Hosseini-Kamkar, Sylvia M L Cox, Nicole Palacio Prada, Maisha Iqbal , et al. · 2025

Importance Psychiatric comorbidity is the norm. Identifying transdiagnostic risk factors will inform our understanding of developmental pathways and early intervention targets. Objective We recently reported that many psychiatric outcomes …

Psychotic-like experiences and white matter microstructure: A fixel-based analysis approach with robust replication across two cohorts Open

Isabella Goodwin, Kit Melissa Larsen, Arshiya Sangchooli, Robert B. Smith, Tobias Banaschewski , et al. · 2025

Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non-clinical psychotic-like experiences, predating illness onset. Whi…

Mapping the coupling between tract reachability and cortical geometry of the human brain Open

Deying Li, Andrew Zalesky, Yufan Wang, Haiyan Wang, Liang Ma , et al. · 2025

The study of cortical geometry and connectivity is prevalent in research on the human brain. However, these two aspects of brain structure are usually examined separately, leaving the essential connections between the brain’s folding patte…

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