Tobias Baumann
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View article: Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells
Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells Open
Loss of anticancer natural killer (NK) cell function in patients with acute myeloid leukemia (AML) is associated with fatal disease progression and remains poorly understood. Here, we demonstrate that AML blasts isolated from patients rapi…
View article: Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity
Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity Open
Natural killer (NK) cells are critical for anti-metastatic immunity and can eliminate metastasizing tumor cells within circulation and sites of metastatic seeding. Here, we show that disseminated tumor cells (DTCs) colonizing the mouse lun…
View article: Orthogonal translation with 5‐cyanotryptophan as an infrared probe for local structural information, electrostatics, and hydrogen bonding
Orthogonal translation with 5‐cyanotryptophan as an infrared probe for local structural information, electrostatics, and hydrogen bonding Open
Orthogonal translation is an efficient tool that provides many valuable spectral probes capable of covering different parts of the electromagnetic spectrum and thus enabling parameterization of various structural and dynamic phenomena in p…
View article: Manufacturing Constraints in Topology Optimization for the Direct Manufacturing of Extrusion-Based Additively Manufactured Parts
Manufacturing Constraints in Topology Optimization for the Direct Manufacturing of Extrusion-Based Additively Manufactured Parts Open
Additive manufacturing is a potentially disruptive technology with a high impact on supply chains and part design. While generally allowing much higher degrees of freedom in design than formative and subtractive manufacturing techniques, t…
View article: Stereotype in der Schule: Auswirkungen auf das Classroom Management
Stereotype in der Schule: Auswirkungen auf das Classroom Management Open
Sabine Glock und Tobias Baumann nehmen die Auswirkung von negativen Stereotypen auf die Erwartungen an Schüler*innen und auf den Umgang mit Unterrichtsstörungen in den Blick. Etliche Studien würden darauf hinweisen, dass von Klassen, in de…
View article: Engineered bacterial host for genetic encoding of physiologically stable protein nitration
Engineered bacterial host for genetic encoding of physiologically stable protein nitration Open
Across scales, many biological phenomena, such as protein folding or bioadhesion and cohesion, rely on synergistic effects of different amino acid side chains at multiple positions in the protein sequence. These are often fine-tuned by pos…
View article: Halogenation of tyrosine perturbs large-scale protein self-organization
Halogenation of tyrosine perturbs large-scale protein self-organization Open
View article: CCC - integrated multiscale study of salt cavern abandonment in the Netherlands
CCC - integrated multiscale study of salt cavern abandonment in the Netherlands Open
The KEM-17 project of the Dutch State Supervision of Mines presented a critical review of concepts of cavern abandonment and related science. It recommended that analyses of cavern abandonment are done as an integrated project, addressing …
View article: Cooperative Artificial Intelligence
Cooperative Artificial Intelligence Open
In the future, artificial learning agents are likely to become increasingly widespread in our society. They will interact with both other learning agents and humans in a variety of complex settings including social dilemmas. We argue that …
View article: IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells Open
View article: Halogenation of Tyrosine perturbs large-scale protein self-organization
Halogenation of Tyrosine perturbs large-scale protein self-organization Open
Data share-Halogenation of Tyrosine perturbs large-scale protein self-organization
View article: Efficient Unnatural Protein Production by Pyrrolysyl-tRNA Synthetase With Genetically Fused Solubility Tags
Efficient Unnatural Protein Production by Pyrrolysyl-tRNA Synthetase With Genetically Fused Solubility Tags Open
Introducing non-canonical amino acids (ncAAs) by engineered orthogonal pairs of aminoacyl-tRNA synthetases and tRNAs has proven to be a highly useful tool for the expansion of the genetic code. Pyrrolysyl-tRNA synthetase (PylRS) from metha…
View article: Performance Evaluation and Improvements of the PoCL Open-Source OpenCL Implementation on Intel CPUs
Performance Evaluation and Improvements of the PoCL Open-Source OpenCL Implementation on Intel CPUs Open
The Portable Computing Language (PoCL) is a vendor independent open-source OpenCL implementation that aims to support a variety of compute devices in a single platform. Evaluating PoCL versus the Intel OpenCL implementation reveals signifi…
View article: Expanding the Scope of Orthogonal Translation with Pyrrolysyl-tRNA Synthetases Dedicated to Aromatic Amino Acids
Expanding the Scope of Orthogonal Translation with Pyrrolysyl-tRNA Synthetases Dedicated to Aromatic Amino Acids Open
In protein engineering and synthetic biology, Methanosarcina mazei pyrrolysyl-tRNA synthetase (MmPylRS), with its cognate tRNAPyl, is one of the most popular tools for site-specific incorporation of non-canonical amino acids (ncAAs). Numer…
View article: Adaptive Mechanism Design: Learning to Promote Cooperation
Adaptive Mechanism Design: Learning to Promote Cooperation Open
In the future, artificial learning agents are likely to become increasingly widespread in our society. They will interact with both other learning agents and humans in a variety of complex settings including social dilemmas. We consider th…
View article: Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal
Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal Open
View article: rAAV Engineering for Capsid-Protein Enzyme Insertions and Mosaicism Reveals Resilience to Mutational, Structural and Thermal Perturbations
rAAV Engineering for Capsid-Protein Enzyme Insertions and Mosaicism Reveals Resilience to Mutational, Structural and Thermal Perturbations Open
Recombinant adeno-associated viruses (rAAV) provide outstanding options for customization and superior capabilities for gene therapy. To access their full potential, facile genetic manipulation is pivotal, including capsid loop modificatio…
View article: PS1214 INFECTIOUS COMPLICATIONS FOLLOWING ARI‐0001 CELL (A3B1:CD8:4–1BB:CD3Z CART19) TREATMENT IN ADULT AND PEDIATRIC PATIENTS WITH CD19+ RELAPSED / REFRACTORY MALIGNANCIES
PS1214 INFECTIOUS COMPLICATIONS FOLLOWING ARI‐0001 CELL (A3B1:CD8:4–1BB:CD3Z CART19) TREATMENT IN ADULT AND PEDIATRIC PATIENTS WITH CD19+ RELAPSED / REFRACTORY MALIGNANCIES Open
Background: Several chimeric antigen receptor products targeting CD19 are either approved or in development for the treatment of acute lymphoblastic leukemia (ALL) and non‐Hodgkin's lymphoma (NHL). Nevertheless, information on infections a…
View article: Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine
Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine Open
Engineering aminoacyl-tRNA synthetases (aaRSs) provides access to the ribosomal incorporation of noncanonical amino acids via genetic code expansion. Conventional targeted mutagenesis libraries with 5–7 positions randomized cover only marg…
View article: Rücktitelbild: Ortsaufgelöste Beobachtung von Schwingungsenergietransfer durch ein genetisch codiertes ultraschnelles Heizelement (Angew. Chem. 9/2019)
Rücktitelbild: Ortsaufgelöste Beobachtung von Schwingungsenergietransfer durch ein genetisch codiertes ultraschnelles Heizelement (Angew. Chem. 9/2019) Open
Schwingungsenergietransfer (VET) in Proteinen wird in Computerstudien mit Allosterie und anderen Aspekten der Proteinfunktion in Verbindung gebracht. J. Bredenbeck, N. Budisa und Mitarbeiter zeigen in ihrer Zuschrift auf S. 2925, wie Schwi…
View article: Back Cover: Site‐Resolved Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater (Angew. Chem. Int. Ed. 9/2019)
Back Cover: Site‐Resolved Observation of Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater (Angew. Chem. Int. Ed. 9/2019) Open
Vibrational energy transfer (VET) in proteins has been linked to allostery and other aspects of protein function in computational studies. In their Communication on page 2899 ff., J. Bredenbeck, N. Budisa, and co-workers show how vibration…
View article: Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids Open
Nature has a variety of possibilities to create new protein functions by modifying the sequence of the individual amino acid building blocks. However, all variations are based on the 20 canonical amino acids (cAAs). As a way to introduce a…
View article: Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids Open
Nature has a variety of possibilities to create new protein functions by modifying the sequence of the individual amino acid building blocks. However, all variations are based on the 20 canonical amino acids (cAAs). As a way to introduce a…
View article: Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence
Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence Open
Fluorescent proteins are fundamental tools for the life sciences, in particular for fluorescence microscopy of living cells. While wild-type and engineered variants of the green fluorescent protein from Aequorea victoria (avGFP) as well as…
View article: Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics
Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics Open
The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the Gram-positive bacterium Lactococcus lactis, bears great potential to expand the che…
View article: Oral Sessions
Oral Sessions Open
Background: Many questionnaire surveys around the globe have investigated the management of carious lesions in adults, but there is a lack of data for children in general and for primary teeth in particular.Aim: The aim of the present ques…
View article: Front Cover: Photoactivatable Mussel‐Based Underwater Adhesive Proteins by an Expanded Genetic Code (ChemBioChem 18/2017)
Front Cover: Photoactivatable Mussel‐Based Underwater Adhesive Proteins by an Expanded Genetic Code (ChemBioChem 18/2017) Open
The cover picture shows a new concept for producing DOPA-rich underwater adhesive proteins from marine mussels by genetic code expansion. By using computational design and genetic selection methods, a novel Methanocaldococcus jannaschii ty…
View article: Prospects of In vivo Incorporation of Non-canonical Amino Acids for the Chemical Diversification of Antimicrobial Peptides
Prospects of In vivo Incorporation of Non-canonical Amino Acids for the Chemical Diversification of Antimicrobial Peptides Open
The incorporation of non-canonical amino acids (ncAA) is an elegant way for the chemical diversification of recombinantly produced antimicrobial peptides (AMPs). Residue- and site-specific installation methods in several bacterial producti…
View article: Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation
Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation Open
Fluorine being not substantially present in the chemistry of living beings is an attractive element in tailoring novel chemical, biophysical, and pharmacokinetic properties of peptides and proteins. The hallmark of ribosome-mediated artifi…
View article: Molecular Epidemiology of Carbapenem-Resistant Acinetobacter Baumannii Complex Isolates from Patients that were Injured during the Eastern Ukrainian Conflict
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter Baumannii Complex Isolates from Patients that were Injured during the Eastern Ukrainian Conflict Open
This study addressed carbapenem-resistant Acinetobacter baumannii complex (ABC) isolates from patients that were injured during the military conflict in the Eastern Ukraine and treated at German Armed Forces Hospitals in 2014 and 2015. Clo…