Tobias Dallenga
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View article: Redox signaling in innate immunity and inflammation: focus on macrophages and neutrophils
Redox signaling in innate immunity and inflammation: focus on macrophages and neutrophils Open
Redox signaling plays a central role in regulating macrophage and neutrophil function, integrating reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) to modulate innate immune responses. React…
View article: Molecular determinants of multidrug-resistant tuberculosis in Sierra Leone
Molecular determinants of multidrug-resistant tuberculosis in Sierra Leone Open
Multidrug-resistant tuberculosis (MDR-TB) management has become a serious global health challenge. Understanding its epidemic determinants on the regional level is crucial for developing effective control measures. We used whole genome seq…
View article: Evaluation of Myeloperoxidase as Target for Host-Directed Therapy in Tuberculosis In Vivo
Evaluation of Myeloperoxidase as Target for Host-Directed Therapy in Tuberculosis In Vivo Open
Due to the rise of tuberculosis cases infected with multi and extensively drug-resistant Mycobacterium tuberculosis strains and the emergence of isolates resistant to antibiotics newly in clinical use, host-directed therapies targeting pat…
View article: Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex
Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex Open
View article: Author Correction: Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils
Author Correction: Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils Open
View article: Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils
Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils Open
The tuberculosis agent Mycobacterium tuberculosis is primarily transmitted through air, but little is known about the tenacity of mycobacterium-containing aerosols derived from either suspensions or infected neutrophils. Analysis of mycoba…
View article: Pulmonale Immunität bei Tuberkulose
Pulmonale Immunität bei Tuberkulose Open
Zusammenfassung Tuberkulose wird durch Inhalation von bakterienhaltigen Aerosolen übertragen und 75 % der Erkrankungen betreffen die Lunge. Die Immunprozesse zwischen Exposition und Krankheitsentwicklung sind großenteils auf die Lunge besc…
View article: Strategies to Improve Vaccine Efficacy against Tuberculosis by Targeting Innate Immunity
Strategies to Improve Vaccine Efficacy against Tuberculosis by Targeting Innate Immunity Open
The global tuberculosis epidemic is the most common cause of death after infectious disease worldwide. Increasing numbers of infections with multi- and extensively drug-resistant variants of the Mycobacterium tuberculosis complex, r…
View article: M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages
M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages Open
View article: Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis
Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis Open
Our data indicate that in multiple sclerosis, ongoing demyelination in focal lesions is associated with axonal degeneration in the perilesional white matter, supporting a role for focal pathology in diffuse white matter damage. Also, our r…
View article: Neutrophils in tuberculosis – first line of defence or booster of disease and targets for host directed therapy?
Neutrophils in tuberculosis – first line of defence or booster of disease and targets for host directed therapy? Open
Necrotizing granulomas, exacerbating pathogenesis and neutrophil influx at the site of infection are hallmarks of active pulmonary tuberculosis (TB) in humans. The role of polymorphonuclear neutrophils (PMN) in host defence and TB pathogen…