Tobias F. Rinke de Wit
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View article: Health facility revisit and its associated factors among clients utilizing public health facilities in Zanzibar: a retrospective cohort study
Health facility revisit and its associated factors among clients utilizing public health facilities in Zanzibar: a retrospective cohort study Open
The findings suggest a need to enhance the efficiency of health service delivery, especially at lower levels, to reduce avoidable revisits and consequently reduce the cost per patient. The findings can also be used as a resource to inform …
View article: Post-market quality monitoring of medicines in Christian Health Association of Ghana health institutions
Post-market quality monitoring of medicines in Christian Health Association of Ghana health institutions Open
Objective: To determine the quality of selected frequently used medicines in CHAG facilities in a LMIC country setting.Design: Quality testing of collected samples of generic medicines in health facility pharmacies.Setting and participatin…
View article: The Acceptability of a Real-Time Medication Monitoring-Based Digital Adherence Tool Among Young People Living with HIV in Malawi
The Acceptability of a Real-Time Medication Monitoring-Based Digital Adherence Tool Among Young People Living with HIV in Malawi Open
Adherence to antiretroviral therapy (ART) is required for young people living with HIV (YPLHIV, 15-24 years) to achieve viral suppression, prevent transmission, and reduce HIV-related morbidity and mortality. Real time medication monitorin…
View article: Artificial intelligence (AI)-driven rapid diagnostic test interpretation in a Connected Diagnostics (ConnDx) system for dynamic malaria surveillance
Artificial intelligence (AI)-driven rapid diagnostic test interpretation in a Connected Diagnostics (ConnDx) system for dynamic malaria surveillance Open
Background Despite progress made towards malaria control in endemic countries, key indicators have stalled since 2015. Achieving the World Health Organization's (WHO) Global Technical Strategy for Malaria 2016–2030 targets—aiming for 90% r…
View article: Monitoring SARS-CoV-2 variants in wastewater during periods of low clinical case surveillance in Ethiopia
Monitoring SARS-CoV-2 variants in wastewater during periods of low clinical case surveillance in Ethiopia Open
Wastewater-based genomic surveillance is a cost-effective approach for tracking outbreaks like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A 2023 study in Addis Ababa, Ethiopia, revealed two infection waves in March and A…
View article: Genomic Characterization of <i>Leishmania tropica</i> in Cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023
Genomic Characterization of <i>Leishmania tropica</i> in Cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023 Open
We sequenced Leishmania tropica genomes from 8 human skin samples collected in a newly emerging focus of cutaneous leishmaniasis in the Somali region of Ethiopia. We found a variant with unique genomic signatures of drug resistance. Public…
View article: Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19
Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19 Open
Introduction Little is known about the acute and long-term sequelae of COVID-19 and its pathophysiology in African patients, who are known to have a distinct immunological profile compared to Caucasian populations. Here, we established pro…
View article: Determinants of lost-to-follow-up (LTFU) among National Health Insurance Scheme-insured hypertension and diabetes patients attending accredited health facilities in Ghana
Determinants of lost-to-follow-up (LTFU) among National Health Insurance Scheme-insured hypertension and diabetes patients attending accredited health facilities in Ghana Open
View article: 201 The business model of quality improvement and drivers of success of a private tertiary hospital in Lagos, Nigeria
201 The business model of quality improvement and drivers of success of a private tertiary hospital in Lagos, Nigeria Open
View article: Stakeholders’ perspectives and experiences with the quality of essential medicines in primary healthcare facilities in Ghana: a qualitative study
Stakeholders’ perspectives and experiences with the quality of essential medicines in primary healthcare facilities in Ghana: a qualitative study Open
Background The availability of safe, effective, and affordable medicines indicates a quality health service and the achievement of a significant target area of universal health coverage. Health inequity in the global health system, due to …
View article: Impact of value-based care on quality of life, clinical outcomes, patient satisfaction, and enhanced financial protection among hypertensive patients in Ghana: A protocol for a mixed method evaluation, 2024
Impact of value-based care on quality of life, clinical outcomes, patient satisfaction, and enhanced financial protection among hypertensive patients in Ghana: A protocol for a mixed method evaluation, 2024 Open
Background Evidence on which hypertensive intervention is cost-effective is essential to inform strategy, policy development, practice, implementation, and resource allocation. Value-Based Care (VBC) is a healthcare delivery model that emp…
View article: Mpox after COVID-19 in Africa: Different epidemic, similar challenges
Mpox after COVID-19 in Africa: Different epidemic, similar challenges Open
Africa faces again a new outbreak of mpox, heavily burdening the Democratic Republic of Congo (DRC). Factors such as biological and ecological changes in the virus, waning of immunity to smallpox, socio-economic challenges, and global econ…
View article: Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023
Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022–2023 Open
In Ethiopia, dengue virus (DENV) infections have been reported in several regions; however, little is known about the genetic diversity of circulating viruses. We conducted clinical surveillance of DENV during the 2023 nationwide outbreak …
View article: Improving transparency in malaria programme funds: A business case for connected diagnostics in Kenya
Improving transparency in malaria programme funds: A business case for connected diagnostics in Kenya Open
Background: International vertical health financing programmes risk functioning in parallel with existing domestic funding in low- and middle-income countries (LMICs), leading to inefficient service delivery and concomitant poor health out…
View article: Leveraging local health system resources to address quality healthcare gaps in sub-Saharan African: lessons from the SafeCare quality improvement programme in Ghana
Leveraging local health system resources to address quality healthcare gaps in sub-Saharan African: lessons from the SafeCare quality improvement programme in Ghana Open
SafeCare QI programme has contributed to QI and adherence to patient safety standards in Ghana. Sustainability is however dependent on continuous government commitment as the programme gets adopted as a national QI programme. Overlaps in c…
View article: Health facility revisit and its associated factors among clients utilizing public health facilities in Zanzibar
Health facility revisit and its associated factors among clients utilizing public health facilities in Zanzibar Open
Background Since 1964, healthcare in Zanzibar has been funded by the government through taxes and is free for all at all points of care. As this system is financially unsustainable, Zanzibar’s healthcare system is undergoing a reform. The …
View article: Genomic characterization of a unique population of<i>Leishmania tropica</i>in a new emerging focus of cutaneous leishmaniasis in Somali region of Ethiopia
Genomic characterization of a unique population of<i>Leishmania tropica</i>in a new emerging focus of cutaneous leishmaniasis in Somali region of Ethiopia Open
We sequenced Leishmania tropica genomes directly from eight human skin samples collected in a newly emerging focus of cutaneous leishmaniasis in Somali region, Ethiopia. We found a new variant with unique genomic signatures of drug resista…
View article: Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19
Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19 Open
Little is known about the acute and long-term sequelae of COVID-19 and its pathophysiology in African patients, who are known to have a distinct immunological profile compared to Caucasian populations. Here, we established proteomic signat…
View article: Longitudinal wastewater-based surveillance of SARS-CoV-2 during 2023 in Ethiopia
Longitudinal wastewater-based surveillance of SARS-CoV-2 during 2023 in Ethiopia Open
Introduction Although wastewater-based epidemiology (WBE) successfully functioned as a tool for monitoring the coronavirus disease 2019 (COVID-19) pandemic globally, relatively little is known about its utility in low-income countries. Thi…
View article: Diversity of culturable bacterial isolates and their potential as antimicrobial against human pathogens from Afar region, Ethiopia
Diversity of culturable bacterial isolates and their potential as antimicrobial against human pathogens from Afar region, Ethiopia Open
Antimicrobial resistance is a growing global concern exacerbated by the scarcity of new medications and resistance to current antibiotics. Microbes from unexplored habitats are promising sources of natural products to combat this challenge…
View article: Technical efficiency of ghanaian health facilities before and during the COVID-19 pandemic
Technical efficiency of ghanaian health facilities before and during the COVID-19 pandemic Open
View article: Genomic characterization of Dengue virus circulation in Ethiopia
Genomic characterization of Dengue virus circulation in Ethiopia Open
In Ethiopia, dengue virus (DENV) infections have been reported in several regions, however, little is known about the circulating genetic diversity. Here, we conducted clinical surveillance for DENV during the 2023 nationwide outbreak and …
View article: Impact of Value-Based Care on Quality of Life, Clinical Outcomes, Patient Satisfaction, and Enhanced Financial Protection among Hypertensive Patients inGhana: A Protocol for a Mixed Method Evaluation, 2024
Impact of Value-Based Care on Quality of Life, Clinical Outcomes, Patient Satisfaction, and Enhanced Financial Protection among Hypertensive Patients inGhana: A Protocol for a Mixed Method Evaluation, 2024 Open
Background Hypertension remains a major public health concern in low and middle-income countries as most hypertensive patients are not adequately treated, and improper lifestyle modification and expensive and inadequate antihypertensive me…
View article: The Effect of Real-Time Medication Monitoring-Based Digital Adherence Tools on Adherence to Antiretroviral Therapy and Viral Suppression in People Living With HIV: A Systematic Literature Review and Meta-Analysis
The Effect of Real-Time Medication Monitoring-Based Digital Adherence Tools on Adherence to Antiretroviral Therapy and Viral Suppression in People Living With HIV: A Systematic Literature Review and Meta-Analysis Open
Background: Universal antiretroviral therapy (ART) has led to improved treatment outcomes in persons living with HIV. Adherence to ART is required to achieve viral suppression. Real-time medication monitoring (RTMM)–based digital adherence…
View article: Preparing healthcare facilities in sub-Saharan Africa for future outbreaks: insights from a multi-country digital self-assessment of COVID-19 preparedness
Preparing healthcare facilities in sub-Saharan Africa for future outbreaks: insights from a multi-country digital self-assessment of COVID-19 preparedness Open
View article: Specific plasma microRNAs are associated with CD4+ T-cell recovery during suppressive antiretroviral therapy for HIV-1
Specific plasma microRNAs are associated with CD4+ T-cell recovery during suppressive antiretroviral therapy for HIV-1 Open
Objective: This study investigated the association of plasma microRNAs before and during antiretroviral therapy (ART) with poor CD4 + T-cell recovery during the first year of ART. Design: MicroRNAs were retrospectively measured in stored p…
View article: Stability in care and risk of loss to follow‐up among clients receiving community health worker‐led differentiated <scp>HIV</scp> care: Results from a prospective cohort study in northern Tanzania
Stability in care and risk of loss to follow‐up among clients receiving community health worker‐led differentiated <span>HIV</span> care: Results from a prospective cohort study in northern Tanzania Open
Background HIV services in Tanzania are facility‐based but facilities are often overcrowded. Differentiated care models (DCM) have been introduced into the National Guidelines. We piloted a Community Health Worker (CHW)‐led HIV treatment c…
View article: Quality assessment of medicines in selected resource-limited primary healthcare facilities using low- to medium-cost field testing digital technologies
Quality assessment of medicines in selected resource-limited primary healthcare facilities using low- to medium-cost field testing digital technologies Open
Background Digital technologies can assess the quality of medicines in resource-challenged health facilities in a timely manner and ensure effective healthcare. Objectives This study assessed the quality of some non-communicable disease me…
View article: PA-234 Digital adherence tools with personalized adherence feedback: a promising guide for adherence counselling among children and adolescents living with HIV in Tanzania. A mixed-methods study
PA-234 Digital adherence tools with personalized adherence feedback: a promising guide for adherence counselling among children and adolescents living with HIV in Tanzania. A mixed-methods study Open
Background Adherence to treatment is a challenge to people living with HIV (PLHIV). Therefore, interventions are highly needed to assist PLHIV in adhering well to medication. Digital adherence tools (DAT) that offer real-time intervention …
View article: Developing contents for a digital adherence tool: A formative mixed-methods study among children and adolescents living with HIV in Tanzania
Developing contents for a digital adherence tool: A formative mixed-methods study among children and adolescents living with HIV in Tanzania Open
Optimal adherence (>95%) to antiretroviral treatment (ART) remains a challenge among children and adolescents living with HIV (CALHIV). Digital adherence tools (DAT) with reminder cues have proven feasible among adult people living with HI…