Tobias M. Brunner
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View article: Plasticity and lineage commitment of individual T<sub>H</sub>1 cells are determined by stable T-bet expression quantities
Plasticity and lineage commitment of individual T<sub>H</sub>1 cells are determined by stable T-bet expression quantities Open
T helper 1 (T H 1) cell identity is defined by the expression of the lineage-specifying transcription factor T-bet. Here, we examine the influence of T-bet expression heterogeneity on subset plasticity by leveraging cell sorting of distinc…
View article: A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses
A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses Open
View article: GATA-3 Localization Shapes Lymphocyte Function
GATA-3 Localization Shapes Lymphocyte Function Open
View article: NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis
NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis Open
Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain. Although age and joint trauma are prominently associated with OA occurrence, the trigger and signaling pathways propagating their pathogenic aspects are…
View article: The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection Open
Raw data underlying the publication
View article: The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection Open
T cell factor 1 (Tcf-1) expressing CD8+ T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection and cancer. Yet, the signals that promote the formation and maintena…
View article: A type-1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T cell responses
A type-1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T cell responses Open
The pleiotropic alarmin interleukin-33 (IL-33) drives type-1, type-2, and regulatory T-cell responses via its receptor ST2. Subset-specific differences in ST2 expression intensity and dynamics suggest that transcriptional regulation is key…
View article: Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities
Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities Open
SUMMARY T helper 1 (Th1) cell identity is defined by the expression of the lineage-defining transcription factor T-bet. Here, we examine the influence of T-bet expression heterogeneity on subset plasticity by leveraging cell sorting of dis…
View article: Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth
Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth Open
Bone growth requires a specialised, highly angiogenic blood vessel subtype, so-called type H vessels, which pave the way for osteoblasts surrounding these vessels. At the end of adolescence, type H vessels differentiate into quiescent type…
View article: Menstrual blood-derived mesenchymal stromal cells efficiently ameliorate experimental autoimmune encephalomyelitis by inhibiting T cell activation in mice
Menstrual blood-derived mesenchymal stromal cells efficiently ameliorate experimental autoimmune encephalomyelitis by inhibiting T cell activation in mice Open
View article: Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection
Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection Open
Significance Vaccines against persisting viruses such as HIV or hepatitis C virus remain a significant unmet global need. Long-lived memory B cells can be induced by vaccination to form an important pillar of antiviral immunity, yet persis…
View article: Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection"
Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection" Open
Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".
View article: Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection"
Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection" Open
Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".
View article: Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10
Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10 Open
Significance Strategies to suppress memory T cell responses are needed. Th2-polarized cells lacking the transcription factor T-bet strongly suppress not only naive but also memory T cell responses via IL-10 and protect mice against the dev…
View article: Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals
Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals Open
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined. Viral infections can trigger the release of the alarmin interleukin-33 …