Tobias Weil
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View article: Exploring Antibiotic Resistance in Earth’s Coldest Regions
Exploring Antibiotic Resistance in Earth’s Coldest Regions Open
Antibiotics, important medicines that fight harmful bacteria, face a big problem: bacteria are becoming increasingly resistant. This means that bacteria are changing in ways that antibiotics designed to kill them do not cause any harm anym…
View article: Hypericum hircinum L.: Botany, Traditional Uses, Phytochemistry, and Pharmacological Properties
Hypericum hircinum L.: Botany, Traditional Uses, Phytochemistry, and Pharmacological Properties Open
Hypericum hircinum L., commonly known as goat St. John’s wort or stinking tutsan, is a medicinal plant native to the Mediterranean basin and widespread across Europe and parts of the Middle East. It has a long history of traditional uses i…
View article: Temporal Changes in Tick‐Borne Pathogen Prevalence in Questing <i>Ixodes ricinus</i> Across Different Habitats in the North‐Eastern Italian Alps
Temporal Changes in Tick‐Borne Pathogen Prevalence in Questing <i>Ixodes ricinus</i> Across Different Habitats in the North‐Eastern Italian Alps Open
Changes in land use, climate, and host community are leading to increased complexity in eco‐epidemiological relationships and the emergence of zoonoses. This study investigates the changes in the prevalence of several Ixodes ricinus ‐trans…
View article: From remote to urbanized: Dispersal of antibiotic-resistant bacteria under the aspect of anthropogenic influence
From remote to urbanized: Dispersal of antibiotic-resistant bacteria under the aspect of anthropogenic influence Open
Antibiotic resistance is a growing global concern, but our understanding of the spread of resistant bacteria in remote regions remains limited. While some level of intrinsic resistance likely contributes to reduced susceptibility to antimi…
View article: Antifungal and Antiparasitic Activities of Metallocene-Containing Fluconazole Derivatives
Antifungal and Antiparasitic Activities of Metallocene-Containing Fluconazole Derivatives Open
The search for new anti-infectives based on metal complexes is gaining momentum. Among the different options taken by researchers, the one involving the use of organometallic complexes is probably the most successful one with a compound, n…
View article: Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry
Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry Open
Drug resistance observed with many anti-infectives clearly highlights the need for new broad-spectrum agents to treat especially neglected tropical diseases (NTDs) caused by eukaryotic parasitic pathogens, including fungal infections. Here…
View article: Antifungal and Antiparasitic Activity of Novel Metallocene-containing Fluconazole Derivatives
Antifungal and Antiparasitic Activity of Novel Metallocene-containing Fluconazole Derivatives Open
The search for new anti-infectives based on metal complexes is gaining momentum. Among the different options taken by researchers, the one involving the use of organometallic complexes is probably the most successful one with a compound, n…
View article: A comparative approach to confirm antibiotic-resistant microbes in the cryosphere
A comparative approach to confirm antibiotic-resistant microbes in the cryosphere Open
Antibiotic-resistant microbes pose one of the biggest challenges of the current century. While areas with proximity to human impact are closely studied, a lot is yet to learn about antimicrobial resistance in remote regions like the cryosp…
View article: Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry
Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry Open
Drug resistance observed with many anti-infectives clearly highlights the need for new broad-spectrum agents to treat especially neglected tropical diseases (NTDs) caused by eukaryotic parasitic pathogens including fungal infections. Since…
View article: From Remote to Urbanized: Dispersal of Antibiotic-Resistant Bacteria Under the Aspect of Anthropogenic Influence
From Remote to Urbanized: Dispersal of Antibiotic-Resistant Bacteria Under the Aspect of Anthropogenic Influence Open
View article: Microbial and metabolic characterization of organic artisanal sauerkraut fermentation and study of gut health-promoting properties of sauerkraut brine
Microbial and metabolic characterization of organic artisanal sauerkraut fermentation and study of gut health-promoting properties of sauerkraut brine Open
Sauerkraut is a traditionally fermented cabbage, and recent evidence suggests that it has beneficial properties for human health. In this work, a multi-disciplinary approach was employed to characterize the fermentation process and gut hea…
View article: Investigating the microbial community of <i>Cacopsylla</i> spp. as potential factor in vector competence of phytoplasma
Investigating the microbial community of <i>Cacopsylla</i> spp. as potential factor in vector competence of phytoplasma Open
Phytoplasmas are obligatory intracellular bacteria that colonize the phloem of many plant species and cause hundreds of plant diseases worldwide. In nature, phytoplasmas are primarily transmitted by hemipteran vectors. While all phloem‐fee…
View article: Processed Animal Proteins from Insect and Poultry By-Products in a Fish Meal-Free Diet for Rainbow Trout: Impact on Intestinal Microbiota and Inflammatory Markers
Processed Animal Proteins from Insect and Poultry By-Products in a Fish Meal-Free Diet for Rainbow Trout: Impact on Intestinal Microbiota and Inflammatory Markers Open
Sustainability of aquaculture is tied to the origin of feed ingredients. In search of sustainable fish meal-free formulations for rainbow trout, we evaluated the effect of Hermetia illucens meal (H) and poultry by-product meal (P), singly …
View article: <i>In vivo</i> active organometallic-containing antimycotic agents
<i>In vivo</i> active organometallic-containing antimycotic agents Open
Fungal infections represent a global problem and there is an urgent need for new drugs. In this work, we prepared four novel organometallic derivatives of the frontline antifungal drug fluconazole with very promising in vivo activity.
View article: Potent Antifungal Properties of Dimeric Acylphloroglucinols from Hypericum mexicanum and Mechanism of Action of a Highly Active 3′Prenyl Uliginosin B
Potent Antifungal Properties of Dimeric Acylphloroglucinols from Hypericum mexicanum and Mechanism of Action of a Highly Active 3′Prenyl Uliginosin B Open
The success of antifungal therapies is often hindered by the limited number of available drugs. To close the gap in the antifungal pipeline, the search of novel leads is of primary importance, and here the exploration of neglected plants h…
View article: Linking omics and ecology to dissect interactions between the apple proliferation phytoplasma and its psyllid vector Cacopsylla melanoneura
Linking omics and ecology to dissect interactions between the apple proliferation phytoplasma and its psyllid vector Cacopsylla melanoneura Open
View article: From Design to in Vivo Active Organometallic-Containing Antimycotic Agents
From Design to in Vivo Active Organometallic-Containing Antimycotic Agents Open
Fungal infections are an alarming global problem, most importantly for immunocompromised patients in a hospital environment. The appearance of multidrug resistance in several fungal species is a strong indication that alternative treatment…
View article: From Design to in Vivo Active Organometallic-Containing Antimycotic Agents
From Design to in Vivo Active Organometallic-Containing Antimycotic Agents Open
Fungal infections are an alarming global problem, most importantly for immunocompromised patients in a hospital environment. The appearance of multidrug resistance in several fungal species is a strong indication that alternative treatment…
View article: Population genomics reveals evolution and variation of <scp> <i>Saccharomyces cerevisiae</i> </scp> in the human and insects gut
Population genomics reveals evolution and variation of <span> <i>Saccharomyces cerevisiae</i> </span> in the human and insects gut Open
Summary The quest to discover the variety of ecological niches inhabited by Saccharomyces cerevisiae has led to research in areas as diverse as wineries, oak trees and insect guts. The discovery of fungal communities in the human gastroint…
View article: Extracts From Hypericum hircinum subsp. majus Exert Antifungal Activity Against a Panel of Sensitive and Drug-Resistant Clinical Strains.
Extracts From Hypericum hircinum subsp. majus Exert Antifungal Activity Against a Panel of Sensitive and Drug-Resistant Clinical Strains. Open
During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics calle…
View article: Phenolic profile, chemical relationship and antifungal activity of Andean Hypericum species
Phenolic profile, chemical relationship and antifungal activity of Andean Hypericum species Open
View article: Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans
Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans Open
Infectious diseases caused by drug-resistant fungi are an increasing threat to public health because of the high mortality rates and high costs associated with treatment. Thus, understanding of the molecular mechanisms of drug resistance i…
View article: Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae
Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae Open
The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cer…
View article: Legal immigrants: invasion of alien microbial communities during winter occurring desert dust storms
Legal immigrants: invasion of alien microbial communities during winter occurring desert dust storms Open
Airborne microbial depositions accompanying extreme meteorological events represent a realistic threat for ecosystem and public health. Therefore, monitoring the spread and persistence of storm-travelling alien microbes is a priority while…
View article: Protein synthesis inhibition and GADD34 control IFN‐β heterogeneous expression in response to dsRNA
Protein synthesis inhibition and GADD34 control IFN‐β heterogeneous expression in response to dsRNA Open
View article: Additional file 3: of Legal immigrants: invasion of alien microbial communities during winter occurring desert dust storms
Additional file 3: of Legal immigrants: invasion of alien microbial communities during winter occurring desert dust storms Open
Supplementary Information - Table S5. (XLSX 16Â kb)
View article: Additional file 2: of Legal immigrants: invasion of alien microbial communities during winter occurring desert dust storms
Additional file 2: of Legal immigrants: invasion of alien microbial communities during winter occurring desert dust storms Open
Supplementary Information - Table S2. (XLSX 30Â kb)
View article: Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host with Saccharomyces cerevisiae
Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host with Saccharomyces cerevisiae Open
View article: RUN and FYVE domain–containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4
RUN and FYVE domain–containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4 Open
Autophagy is a key degradative pathway coordinated by external cues, including starvation, oxidative stress, or pathogen detection. Rare are the molecules known to contribute mechanistically to the regulation of autophagy and expressed spe…
View article: Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection
Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection Open
Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of pr…