Toby Barnes
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View article: Differences in nanoscale organization of regulatory active and inactive human chromatin
Differences in nanoscale organization of regulatory active and inactive human chromatin Open
Methodological advances in conformation capture techniques have fundamentally changed our understanding of chromatin architecture. However, the nanoscale organization of chromatin and its cell-to-cell variance are less studied. Analyzing g…
View article: The Active Mechanism of Nucleosome Depletion by Poly(dA:dT) Tracts In Vivo
The Active Mechanism of Nucleosome Depletion by Poly(dA:dT) Tracts In Vivo Open
Poly(dA:dT) tracts cause nucleosome depletion in many species, e.g., at promoters and replication origins. Their intrinsic biophysical sequence properties make them stiff and unfavorable for nucleosome assembly, as probed by in vitro nucle…
View article: The Active Rather than Intrinsic Mechanism of Nucleosome Depletion by Poly(dA:dT) Tracts
The Active Rather than Intrinsic Mechanism of Nucleosome Depletion by Poly(dA:dT) Tracts Open
Poly(dA:dT) tracts cause nucleosome depletion in many species, e.g., at promoters and replication origins. Their intrinsic biophysical sequence properties make them stiff and unfavorable for nucleosome assembly, as probed by in vitro nucle…