Toby C. Cornish
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View article: Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues
Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues Open
Methods for spatially resolved cellular profiling of tissue sections enable in-depth study of inter- and intra-sample heterogeneity but often profile small regions, requiring evaluation of many samples to compensate for limited assessment.…
View article: 3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure
3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure Open
SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer for which few effective therapies exist. Immunotherapies specifically are ineffective in pancreatic cancer, in part due to its unique stromal and immune microenviron…
View article: Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings
Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings Open
Pancreatic ductal adenocarcinoma is a rare but lethal cancer. Recent evidence suggests that pancreatic intraepithelial neoplasia (PanIN), a microscopic precursor lesion that gives rise to pancreatic cancer, is larger and more prevalent tha…
View article: Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues
Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues Open
Methods for spatially resolved cellular profiling using thinly cut sections have enabled in-depth quantitative tissue mapping to study inter-sample and intra-sample differences in normal human anatomy and disease onset and progression. The…
View article: Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings
Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings Open
Pancreatic ductal adenocarcinoma is a rare but lethal cancer. Recent evidence reveals that pancreatic intraepithelial neoplasms (PanINs), the microscopic precursor lesions in the pancreatic ducts that can give rise to invasive pancreatic c…
View article: Supplementary Figure S1-S3 legends from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S1-S3 legends from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S1-S3 legends
View article: Supplementary Figure S2 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S2 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S2: Liver function tests changes after hepatic intraarterial therapy. Liver chemistry (alanine aminotransferase [ALT]
View article: Supplementary Figure S1 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S1 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S1: Quantitative volumetric image analysis.
View article: Supplementary Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Supplementary Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison Open
Supplemental Figures S1 Figure S2, Figure S3 and Table S1 and Table S2
View article: Supplementary Figure S3 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S3 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S3: Treatment related toxicity.
View article: Supplementary Figure S3 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S3 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S3: Treatment related toxicity.
View article: Data from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Data from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Purpose: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with evofosfamide in a rabbit model.Experimental Design: VX2-tumor-bearing rabbits were assigned to 4 intra-arteri…
View article: Supplementary Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Supplementary Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison Open
Supplemental Figures S1 Figure S2, Figure S3 and Table S1 and Table S2
View article: Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison Open
Purpose: PD-L1 expression in the pretreatment tumor microenvironment enriches for response to anti-PD-1/PD-L1 therapies. The purpose of this study was to quantitatively compare the performance of five monoclonal anti-PD-L1 antibodies used …
View article: Supplementary Figure S1-S3 legends from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S1-S3 legends from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S1-S3 legends
View article: Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison Open
Purpose: PD-L1 expression in the pretreatment tumor microenvironment enriches for response to anti-PD-1/PD-L1 therapies. The purpose of this study was to quantitatively compare the performance of five monoclonal anti-PD-L1 antibodies used …
View article: Data from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Data from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Purpose: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with evofosfamide in a rabbit model.Experimental Design: VX2-tumor-bearing rabbits were assigned to 4 intra-arteri…
View article: Supplementary Figure S1 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S1 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S1: Quantitative volumetric image analysis.
View article: Supplementary Figure S2 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Supplementary Figure S2 from Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer Open
Supplementary Figure S2: Liver function tests changes after hepatic intraarterial therapy. Liver chemistry (alanine aminotransferase [ALT]
View article: Supplementary Tables 1-4 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Supplementary Tables 1-4 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Supplementary Tables 1-4 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
View article: Supplementary Figures 4-8 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Supplementary Figures 4-8 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Supplementary Figures 4-8 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
View article: Supplementary Figures 4-8 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Supplementary Figures 4-8 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Supplementary Figures 4-8 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
View article: Data from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Data from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to occur very early in almost all human cancers, perhaps facilitating ge…
View article: Supplementary Tables 1-4 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Supplementary Tables 1-4 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Supplementary Tables 1-4 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
View article: Data from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Data from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to occur very early in almost all human cancers, perhaps facilitating ge…
View article: Supplementary Materials, Figures 1-3 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Supplementary Materials, Figures 1-3 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Supplementary Materials, Figures 1-3 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
View article: Supplementary Materials, Figures 1-3 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
Supplementary Materials, Figures 1-3 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity Open
Supplementary Materials, Figures 1-3 from DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity
View article: Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions
Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions Open
Pancreatic intraepithelial neoplasia (PanIN) is a precursor to pancreatic cancer and represents a critical opportunity for cancer interception. However, the number, size, shape, and connectivity of PanINs in human pancreatic tissue samples…
View article: Cybersecurity and Information Assurance for the Clinical Laboratory
Cybersecurity and Information Assurance for the Clinical Laboratory Open
Background Network-connected medical devices have rapidly proliferated in the wake of recent global catalysts, leaving clinical laboratories and healthcare organizations vulnerable to malicious actors seeking to ransom sensitive healthcare…