Tock Han Lim
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View article: Real world outcomes of faricimab in treatment resistant neovascular age-related macular degeneration among Asian patients
Real world outcomes of faricimab in treatment resistant neovascular age-related macular degeneration among Asian patients Open
To describe the real-world efficacy and safety outcome measurements of faricimab use in treatment-resistant neovascular age-related macular degeneration (nAMD) in a cohort of Asian patients. A tertiary hospital in central Singapore serving…
View article: Examining the Quality of Care Provided at Singapore's Primary Eye Care Model and Lessons Learned to Maintain Quality Care—Mixed‐Methods Study
Examining the Quality of Care Provided at Singapore's Primary Eye Care Model and Lessons Learned to Maintain Quality Care—Mixed‐Methods Study Open
View article: Anti-VEGF treatment switch in real-world DME patients: ranibizumab versus aflibercept for bevacizumab DME non-responding patients (SWIRL study)
Anti-VEGF treatment switch in real-world DME patients: ranibizumab versus aflibercept for bevacizumab DME non-responding patients (SWIRL study) Open
Background/aims To describe the functional outcomes of patients with diabetic macular oedema (DME) non-responsive to bevacizumab switched to ranibizumab or aflibercept over 1 year and the demographic and anatomic predictors of these functi…
View article: Onset of End-Stage Atrophic Age-Related Macular Degeneration as an End Point—A Delphi Study: Classification of Atrophy Meetings Report 7
Onset of End-Stage Atrophic Age-Related Macular Degeneration as an End Point—A Delphi Study: Classification of Atrophy Meetings Report 7 Open
View article: A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes Open
Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little kn…
View article: Generalizability of Deep Neural Networks for Vertical Cup-to-Disc Ratio Estimation in Ultra-Widefield and Smartphone-Based Fundus Images
Generalizability of Deep Neural Networks for Vertical Cup-to-Disc Ratio Estimation in Ultra-Widefield and Smartphone-Based Fundus Images Open
Artificial intelligence can estimate vCDR from different types of fundus images and may be used as a general and interpretable screening tool to improve community reach for diagnosis and management of glaucoma.
View article: A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes Open
Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little kn…
View article: ACUTE ATYPICAL ENDOPHTHALMITIS FOLLOWING INTRAVITREAL SUSTAINED-RELEASE DEXAMETHASONE IMPLANT: A CASE SERIES
ACUTE ATYPICAL ENDOPHTHALMITIS FOLLOWING INTRAVITREAL SUSTAINED-RELEASE DEXAMETHASONE IMPLANT: A CASE SERIES Open
Purpose: To present three cases of acute endophthalmitis following intravitreal sustained-release dexamethasone (Ozurdex) with atypical presentation and to discuss the management of these patients. Methods: A retrospective case series of t…
View article: Analysis of clinically relevant variants from ancestrally diverse Asian genomes
Analysis of clinically relevant variants from ancestrally diverse Asian genomes Open
View article: Diagnosing Persistent Hypertransmission Defects on En Face OCT Imaging of Age-Related Macular Degeneration
Diagnosing Persistent Hypertransmission Defects on En Face OCT Imaging of Age-Related Macular Degeneration Open
View article: Vitrectomy for advanced proliferative diabetic retinopathy: 30 years on
Vitrectomy for advanced proliferative diabetic retinopathy: 30 years on Open
The scourge of diabetes mellitus continues to ravage the world.South East Asia ranks second among seven geographical regions in absolute numbers of patients with diabetes. 1In Malaysia, the prevalence of type 2 diabetes mellitus (T2DM) has…
View article: Comparison of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy
Comparison of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy Open
ClinicalTrials.gov Identifier: NCT01846273.
View article: Comparing efficacy of reduced-fluence and standard-fluence photodynamic therapy in the treatment of polypoidal choroidal vasculopathy
Comparing efficacy of reduced-fluence and standard-fluence photodynamic therapy in the treatment of polypoidal choroidal vasculopathy Open
View article: Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration
Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration Open
View article: EVEREST study report 4: Fluorescein angiography features predictive of polypoidal choroidal vasculopathy
EVEREST study report 4: Fluorescein angiography features predictive of polypoidal choroidal vasculopathy Open
Importance It is important to identify features of polypoidal choroidal vasculopathy (PCV) that differentiate it from typical neovascular age‐related macular degeneration (nAMD) on various imaging modalities, including fluorescein angiogra…
View article: Human pharyngeal microbiota in age-related macular degeneration
Human pharyngeal microbiota in age-related macular degeneration Open
Utilizing an extensive study population from Singapore, our results provided an accurate description of the pharyngeal microbiota profiles in AMD health and disease conditions. Through identification of candidate genera that are different …
View article: Evaluation of indocyanine green angiographic features in symptomatic macular polypoidal choroidal vasculopathy over 24 months: results from the EVEREST II study
Evaluation of indocyanine green angiographic features in symptomatic macular polypoidal choroidal vasculopathy over 24 months: results from the EVEREST II study Open
View article: Eye gaze tracking and its relationship with visual acuity, central visual field and age-related macular degeneration features.
Eye gaze tracking and its relationship with visual acuity, central visual field and age-related macular degeneration features. Open
View article: EVEREST Report 5: Clinical Outcomes and Treatment Response of Polypoidal Choroidal Vasculopathy Subtypes in a Multicenter, Randomized Controlled Trial
EVEREST Report 5: Clinical Outcomes and Treatment Response of Polypoidal Choroidal Vasculopathy Subtypes in a Multicenter, Randomized Controlled Trial Open
The visual outcome following treatment varies with PCV subtype classification. The distinction in clinical outcomes between the PCV subtypes is observed in the initial months following the start of treatment.
View article: Efficacy and Safety of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy
Efficacy and Safety of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy Open
clinicaltrials.gov Identifier: NCT01846273.
View article: HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization
HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization Open
BACKGROUND: Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological stu…
View article: Evaluation of polypoidal choroidal vasculopathy lesions on indocyanine green angiograms in the first year of the EVEREST II study
Evaluation of polypoidal choroidal vasculopathy lesions on indocyanine green angiograms in the first year of the EVEREST II study Open
View article: An automated system to assess eye movement characteristics for individuals with visual impairment in age-related macular degeneration
An automated system to assess eye movement characteristics for individuals with visual impairment in age-related macular degeneration Open
View article: Baseline characteristics of polypoidal choroidal vasculopathy in the EVEREST II Study
Baseline characteristics of polypoidal choroidal vasculopathy in the EVEREST II Study Open
View article: Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans
Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans Open
To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further compare risk factors between those with typical AMD and poly…
View article: Optical Coherence Tomography Angiography Features of Polypoidal Choroidal Vasculopathy and its Correlation with Indocyanine Green Angiography
Optical Coherence Tomography Angiography Features of Polypoidal Choroidal Vasculopathy and its Correlation with Indocyanine Green Angiography Open
View article: Comparison of Treatment Outcomes Among Subtypes of Polypoidal Choroidal Vasculopathy in a Multicenter Randomized Controlled Study (EVEREST study)
Comparison of Treatment Outcomes Among Subtypes of Polypoidal Choroidal Vasculopathy in a Multicenter Randomized Controlled Study (EVEREST study) Open
View article: Drug, delivery and devices for diabetic retinopathy (3Ds in DR)
Drug, delivery and devices for diabetic retinopathy (3Ds in DR) Open
Diabetic Retinopathy (DR) is one of the most common causes of blindness among the working population worldwide. Clearly, there is an unmet clinical need to find better treatment options for DR. Areas covered: The literature search was cond…
View article: EVEREST study report 3: diagnostic challenges of polypoidal choroidal vasculopathy. Lessons learnt from screening failures in the EVEREST study
EVEREST study report 3: diagnostic challenges of polypoidal choroidal vasculopathy. Lessons learnt from screening failures in the EVEREST study Open
Standardised image grading techniques used in EVEREST study enabled effective differentiation of non-PCV from actual PCV.
View article: An Automated System for Multi-model Retinal Image Registration using Novel Low-dimensional Features
An Automated System for Multi-model Retinal Image Registration using Novel Low-dimensional Features Open