Todd A. MacKenzie
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View article: Performance and Improvement of Track and Trigger Scores Before Rescue and Transfer in the General Care Setting
Performance and Improvement of Track and Trigger Scores Before Rescue and Transfer in the General Care Setting Open
Objectives: This work aims to understand the performance of early warning scores calculated using intermittent vital signs to identify general deterioration in the medical/surgical setting and explore the feasibility of implementing near r…
View article: Tissue gene expression analysis approach in a context of high technical and biological heterogeneity
Tissue gene expression analysis approach in a context of high technical and biological heterogeneity Open
RUVg achieved a balance between computational efficiency and low Type I error, while NSDiff was more sensitive but computationally demanding and exhibited higher Type I error. Our approach provides a robust framework for profiling immune g…
View article: Real world telehealth delivery of an evidence based self-management education program for people with epilepsy and cognitive comorbidity
Real world telehealth delivery of an evidence based self-management education program for people with epilepsy and cognitive comorbidity Open
Introduction Cognitive dysfunction is prevalent in epilepsy, and is associated with decreased quality of life. HOme Based Self-management and COgnitive Training CHanges lives (HOBSCOTCH) is an evidence-based self-management program designe…
View article: Effectiveness of Transcarotid vs Transfemoral Carotid Stenting for Stroke Prevention
Effectiveness of Transcarotid vs Transfemoral Carotid Stenting for Stroke Prevention Open
Importance The effectiveness of surgical transcarotid artery revascularization (TCAR) compared with percutaneous transfemoral carotid artery stenting (TF-CAS) for stroke prevention beyond the periprocedural period is poorly quantified. Obj…
View article: Tissue gene expression analysis approach in a context of high technical and biological heterogeneity
Tissue gene expression analysis approach in a context of high technical and biological heterogeneity Open
View article: ‘UltraGUD LP’—ultrasound guided diagnostic LP—a randomizedcontrolled trial. Traditional landmark based lumbar puncture is as effective as ultrasound guided lumbar puncture in outpatient neurology settings
‘UltraGUD LP’—ultrasound guided diagnostic LP—a randomizedcontrolled trial. Traditional landmark based lumbar puncture is as effective as ultrasound guided lumbar puncture in outpatient neurology settings Open
Background Lumbar puncture (LP) is a fundamental procedure in neurology, yet its success is influenced by patient anatomy and provider expertise. Ultrasound guidance has been shown to improve outcomes in emergency and anesthesia settings, …
View article: Correction to: Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in waves 1 through 5 (2013–2019) of the population assessment of tobacco and health (PATH) study
Correction to: Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in waves 1 through 5 (2013–2019) of the population assessment of tobacco and health (PATH) study Open
View article: Multivariable Linear Models Outperform 2-ΔΔCT for qPCR Data Analysis
Multivariable Linear Models Outperform 2-ΔΔCT for qPCR Data Analysis Open
View article: Lymph Node Adiposity and Metabolic Dysfunction-Associated Steatotic Liver Disease
Lymph Node Adiposity and Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as the most common chronic liver disease, is soon to be the leading indication for liver transplantation; however, the diagnosis may remain occul…
View article: Analyzing Qpcr Data: Better Practices to Facilitate Rigor and Reproducibility
Analyzing Qpcr Data: Better Practices to Facilitate Rigor and Reproducibility Open
View article: Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6
Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6 Open
View article: Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor suggest benefits beyond improved CFTR channel function
Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor suggest benefits beyond improved CFTR channel function Open
Gene expression responses by CF AECs exposed to ETI suggest that in addition to improving CFTR channel function, ETI is likely to enhance resistance to bacterial infection by increasing levels of beta-defensin 1 (hBD-1). ETI may also reduc…
View article: Which is the better polyp detection metric: adenomas per colonoscopy or adenoma detection rate? A simulation modeling study
Which is the better polyp detection metric: adenomas per colonoscopy or adenoma detection rate? A simulation modeling study Open
Background and study aims We compared the ability of adenoma detection rate (ADR) and adenoma per colonoscopy (APC) to assess endoscopist detection, using statistical principles and simulations. Patients and methods We simulated a populati…
View article: Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor (ETI) suggest benefits beyond improved CFTR channel function
Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor (ETI) suggest benefits beyond improved CFTR channel function Open
The combination of elexacaftor/tezacaftor/ivacaftor (ETI, Trikafta) reverses the primary defect in Cystic Fibrosis (CF) by improving CFTR mediated Cl - and HCO 3 - secretion by airway epithelial cells (AEC), leading to improved lung functi…
View article: Integrated primary and community mental health care for young adults with serious mental illness: A program evaluation
Integrated primary and community mental health care for young adults with serious mental illness: A program evaluation Open
Aim Young adults with serious mental illness (SMI) have poor physical health and high Emergency Department (ED) and hospital utilization. Integrating primary care into community mental health care may be an important form of early interven…
View article: Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study
Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study Open
Background Colorectal cancer is a leading cause of cancer-related death. Adenomas and serrated polyps are precursors of colorectal cancer, with serrated polyps being more difficult to detect during colonoscopy. The relationship between pro…
View article: Clinical Trial Protocol for “Replace Cysto”: Replacing Invasive Cystoscopy with Urine Testing for Non–muscle-invasive Bladder Cancer Surveillance—A Multicenter, Randomized, Phase 2 Healthcare Delivery Trial Comparing Quality of Life During Cancer Surveillance with Xpert Bladder Cancer Monitor or Bladder EpiCheck Urine Testing Versus Frequent Cystoscopy
Clinical Trial Protocol for “Replace Cysto”: Replacing Invasive Cystoscopy with Urine Testing for Non–muscle-invasive Bladder Cancer Surveillance—A Multicenter, Randomized, Phase 2 Healthcare Delivery Trial Comparing Quality of Life During Cancer Surveillance with Xpert Bladder Cancer Monitor or Bladder EpiCheck Urine Testing Versus Frequent Cystoscopy Open
View article: Erratum
Erratum Open
[This corrects the article DOI: 10.15326/jcopdf.2023.0422.].
View article: Augmenting the Hospital Score with social risk factors to improve prediction for 30-day readmission following acute myocardial infarction
Augmenting the Hospital Score with social risk factors to improve prediction for 30-day readmission following acute myocardial infarction Open
Background: Hospital Score is a well-known and validated tool for predicting readmission risk among diverse patient populations. Integrating social risk factors using natural language processing with the Hospital Score may improve its abil…
View article: Respiratory Symptoms and Continued Cigarette Use vs. E-Cigarette Switching: PATH Study Waves 2-6
Respiratory Symptoms and Continued Cigarette Use vs. E-Cigarette Switching: PATH Study Waves 2-6 Open
View article: Response to commentary on “Automated classification of fat-infiltrated axillary lymph nodes on screening mammograms”
Response to commentary on “Automated classification of fat-infiltrated axillary lymph nodes on screening mammograms” Open
View article: Relationship Between Tobacco Product Use and Health-Related Quality of Life Among Individuals With COPD in Waves 1–5 (2013–2019) of the Population Assessment of Tobacco and Health Study
Relationship Between Tobacco Product Use and Health-Related Quality of Life Among Individuals With COPD in Waves 1–5 (2013–2019) of the Population Assessment of Tobacco and Health Study Open
E-cigarette/cigarette dual use was associated with worse HRQoL compared to ≥5-year cigarette cessation and exclusive cigarette use. Never use and ≥5-year cigarette cessation were the only categories associated with higher HRQoL compared to…
View article: APPLICATION OF QUANTILE DISCRETIZATION AND BAYESIAN NETWORK ANALYSIS TO PUBLICLY AVAILABLE CYSTIC FIBROSIS DATA SETS
APPLICATION OF QUANTILE DISCRETIZATION AND BAYESIAN NETWORK ANALYSIS TO PUBLICLY AVAILABLE CYSTIC FIBROSIS DATA SETS Open
The availability of multiple publicly-available datasets studying the same phenomenon has the promise of accelerating scientific discovery. Meta-analysis can address issues of reproducibility and often increase power. The promise of meta-a…
View article: Endoscopist adenomas-per-colonoscopy detection rates and risk for postcolonoscopy colorectal cancer: data from the New Hampshire Colonoscopy Registry
Endoscopist adenomas-per-colonoscopy detection rates and risk for postcolonoscopy colorectal cancer: data from the New Hampshire Colonoscopy Registry Open
View article: Automated classification of fat-infiltrated axillary lymph nodes on screening mammograms
Automated classification of fat-infiltrated axillary lymph nodes on screening mammograms Open
Objective: Fat-infiltrated axillary lymph nodes (LNs) are unique sites for ectopic fat deposition. Early studies showed a strong correlation between fatty LNs and obesity-related diseases. Confirming this correlation requires large-scale s…
View article: Candidate pathway analysis of surfactant proteins identifies<i>CTSH</i>and<i>SFTA2</i>that influences lung cancer risk
Candidate pathway analysis of surfactant proteins identifies<i>CTSH</i>and<i>SFTA2</i>that influences lung cancer risk Open
Pulmonary surfactant is a lipoprotein synthesized and secreted by alveolar type II cells in lung. We evaluated the associations between 200,139 single nucleotide polymorphisms (SNPs) of 40 surfactant-related genes and lung cancer risk usin…
View article: The association between cervical artery dissection and spinal manipulation among US adults
The association between cervical artery dissection and spinal manipulation among US adults Open
View article: Higher Serrated Polyp Detection Rates Are Associated With Lower Risk of Postcolonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry
Higher Serrated Polyp Detection Rates Are Associated With Lower Risk of Postcolonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry Open
INTRODUCTION: We used New Hampshire Colonoscopy Registry data to examine the association between postcolonoscopy colorectal cancer (PCCRC) and sessile serrated detection rates (SSLDRs). METHODS: We included patients with either a colonosco…
View article: Population-based estimates of the prevalence of children with congenital heart disease and associated comorbidities
Population-based estimates of the prevalence of children with congenital heart disease and associated comorbidities Open
Background Congenital heart defects (CHD) are the most common birth defects and are estimated to affect almost 1% of births annually in the US. CHDs are the leading cause of infant mortality associated with birth defects and can result in …
View article: Data from MicroRNA-10b Expression Correlates with Response to Neoadjuvant Therapy and Survival in Pancreatic Ductal Adenocarcinoma
Data from MicroRNA-10b Expression Correlates with Response to Neoadjuvant Therapy and Survival in Pancreatic Ductal Adenocarcinoma Open
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Diagnosis and management of PDAC are hampered by the absence of sensitive and specific disease biomarkers. MicroRNAs (miRNA) are noncoding regulatory RNAs…