Andrew T. Goldstein
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View article: Experiences of Care and Gaslighting in Patients With Vulvovaginal Disorders
Experiences of Care and Gaslighting in Patients With Vulvovaginal Disorders Open
Importance Medical gaslighting, in which a patient’s concerns are dismissed without proper evaluation, has been described anecdotally in vulvovaginal patient care, but has not been quantified. Objective To use a patient-centered instrument…
View article: (003) MAST-CELL-INDEPENDENT NEUROPROLIFERATIVE VESTIBULODYNIA
(003) MAST-CELL-INDEPENDENT NEUROPROLIFERATIVE VESTIBULODYNIA Open
Introduction Vulvar histopathology remains poorly understood compared to other gynecologic histopathology. In particular, little is known about the vulvar vestibule or its histopathologic mediators of pain and disease, despite being visibl…
View article: (002) LONG-TERM PATIENT SATISFACTION FOLLOWING SURGICAL TREATMENT OF CLITORAL PHIMOSIS AND LABIAL ADHESIONS IN LICHEN SCLEROSUS
(002) LONG-TERM PATIENT SATISFACTION FOLLOWING SURGICAL TREATMENT OF CLITORAL PHIMOSIS AND LABIAL ADHESIONS IN LICHEN SCLEROSUS Open
Introduction Vulvar lichen sclerosus (LS) is a chronic inflammatory skin condition primarily affecting the anogenital region, leading to scarring, sexual dysfunction, and increased risk of squamous cell carcinoma. The pathophysiology invol…
View article: Generalizable deep neural networks for image quality classification of cervical images
Generalizable deep neural networks for image quality classification of cervical images Open
Successful translation of artificial intelligence (AI) models into clinical practice, across clinical domains, is frequently hindered by the lack of image quality control. Diagnostic models are often trained on images with no denotation of…
View article: Phase 2 randomized study of abobotulinumtoxinA in patients with provoked vestibulodynia: dose-finding results
Phase 2 randomized study of abobotulinumtoxinA in patients with provoked vestibulodynia: dose-finding results Open
Background Hypertonicity of the pelvic floor muscles is commonly associated with provoked vestibulodynia (PVD); therefore, patients may benefit from treatments that relax the pelvic floor. Aim To define optimal (safe and efficacious) doses…
View article: Planning Ahead with Care: A Randomized Clinical Trial of a Video Intervention to Improve Caregiver Knowledge of Severe Dementia and Medical Care Decisions
Planning Ahead with Care: A Randomized Clinical Trial of a Video Intervention to Improve Caregiver Knowledge of Severe Dementia and Medical Care Decisions Open
Background Caregivers of individuals living with dementia frequently make medical decisions for care recipients, often without a clear understanding of those needs. Educational tools are needed to guide caregivers about when and how to rai…
View article: Impact of age, race, and medication use on efficacy endpoints in a randomized controlled trial of topical sildenafil cream for the treatment of female sexual arousal disorder
Impact of age, race, and medication use on efficacy endpoints in a randomized controlled trial of topical sildenafil cream for the treatment of female sexual arousal disorder Open
Background A study of topical Sildenafil Cream 3.6% was completed among healthy premenopausal women with female sexual arousal disorder. Aims To compare efficacy endpoints based on product use in pre-planned and post-hoc subsets of age, ra…
View article: Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder
Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder Open
Background There are currently no Food and Drug Administration–approved treatments for female sexual arousal disorder (FSAD), which is physiologically analogous to male erectile dysfunction. Aims The study sought to test the systemic and l…
View article: Comparisons and correlations of 1-month recall vs 24-hour recall in patient-reported outcomes of an exploratory, phase 2b, randomized, double-blind, placebo-controlled clinical trial of sildenafil cream, 3.6% for the treatment of female sexual arousal disorder
Comparisons and correlations of 1-month recall vs 24-hour recall in patient-reported outcomes of an exploratory, phase 2b, randomized, double-blind, placebo-controlled clinical trial of sildenafil cream, 3.6% for the treatment of female sexual arousal disorder Open
Background Efficacy assessments in clinical trials of treatments for female sexual arousal disorder (FSAD) and other female sexual dysfunction (FSD) diagnoses rely on various patient-reported outcomes (PROs). Aims We sought to compare 1-mo…
View article: Preliminary Efficacy of Topical Sildenafil Cream for the Treatment of Female Sexual Arousal Disorder
Preliminary Efficacy of Topical Sildenafil Cream for the Treatment of Female Sexual Arousal Disorder Open
OBJECTIVE: To assess the efficacy of topical sildenafil cream, 3.6% among healthy premenopausal women with female sexual arousal disorder. METHODS: We conducted a phase 2b, exploratory, randomized, placebo-controlled, double-blind study of…
View article: (092) SEXUAL EXPERIENCES IN AN EXPLORATORY, PHASE 2B, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF SILDENAFIL, 3.6% CREAM FOR THE TREATMENT OF FEMALE SEXUAL AROUSAL DISORDER
(092) SEXUAL EXPERIENCES IN AN EXPLORATORY, PHASE 2B, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF SILDENAFIL, 3.6% CREAM FOR THE TREATMENT OF FEMALE SEXUAL AROUSAL DISORDER Open
Introduction Quantifying the change in the mean number of satisfactory sexual experiences (SSEs) is an efficacy endpoint recommended by the US Food and Drug Administration in studies of treatments for female sexual dysfunctions (FSD), incl…
View article: (094) MEASURES OF FEMALE SEXUAL DISTRESS IN AN EXPLORATORY, PHASE 2B, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF SILDENAFIL CREAM, 3.6% FOR THE TREATMENT OF FEMALE SEXUAL AROUSAL DISORDER
(094) MEASURES OF FEMALE SEXUAL DISTRESS IN AN EXPLORATORY, PHASE 2B, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF SILDENAFIL CREAM, 3.6% FOR THE TREATMENT OF FEMALE SEXUAL AROUSAL DISORDER Open
Introduction The diagnosis of female sexual arousal disorder (FSAD) requires that individuals experience clinically significant distress from their symptoms. Pre-trial content validity investigations were conducted by the sponsor to unders…
View article: (123) Preliminary Efficacy of Sildenafil Cream, 3.6% in an Exploratory, Randomized, Placebo-Controlled, Phase 2b Trial for the Treatment of Female Sexual Arousal Disorder
(123) Preliminary Efficacy of Sildenafil Cream, 3.6% in an Exploratory, Randomized, Placebo-Controlled, Phase 2b Trial for the Treatment of Female Sexual Arousal Disorder Open
Introduction Female sexual arousal disorder (FSAD) is a persistent or recurrent inability to attain, or to maintain until completion of the sexual activity, an adequate lubrication-swelling response of sexual excitement that causes marked …
View article: A survey of patient tolerance and satisfaction with capsaicin for neuroproliferative vestibulodynia
A survey of patient tolerance and satisfaction with capsaicin for neuroproliferative vestibulodynia Open
Background Topical capsaicin has been used to treat vulvodynia but has been poorly studied for use in neuroproliferative provoked vestibulodynia (PVD); capsaicin decreases allodynia by blocking vanilloid receptors (TRPV1) on C-afferent noc…
View article: Pleasure despite pain: Associations between experiences of vulvar pleasure, vulvar pain, and sexual function in patients with chronic vulvar pain conditions
Pleasure despite pain: Associations between experiences of vulvar pleasure, vulvar pain, and sexual function in patients with chronic vulvar pain conditions Open
Background Chronic pain can occur in the vulva, one of the primary pleasure centers of the body; however, the associations between pleasurable vulvar experiences and chronic vulvar pain have not yet been explored. Aim The aim of this study…
View article: (086) Phase II Study of AbobotulinumtoxinA in Patients with Provoked Vestibulodynia: Outcomes From Dose-finding Stage
(086) Phase II Study of AbobotulinumtoxinA in Patients with Provoked Vestibulodynia: Outcomes From Dose-finding Stage Open
Introduction Vulvodynia is associated with significant burden and impaired quality of life and affects up to 28% of women of reproductive age. The most common subtype is provoked vestibulodynia (PVD), in which pain is localized and trigger…
View article: (188) The Female Genitopelvic Pain Subcommittee of the International Consultation of Sexual Medicine: Update on a systematic review of the efficacy and safety of pharmacological, surgical, psychological, and physical therapy treatments for vulvodynia
(188) The Female Genitopelvic Pain Subcommittee of the International Consultation of Sexual Medicine: Update on a systematic review of the efficacy and safety of pharmacological, surgical, psychological, and physical therapy treatments for vulvodynia Open
Introduction Literature on vulvodynia treatment is heterogeneous in terms of intervention type and study quality. A recently published systematic review (SR) of treatments focusing on randomized controlled trials (RCTs) and non-RCTs for pr…
View article: (135) Keratin Pearl Excision for Clitorodynia and Female Sexual Dysfunction
(135) Keratin Pearl Excision for Clitorodynia and Female Sexual Dysfunction Open
Introduction Clitoral adhesions occur when the clitoral prepuce adheres to the glans clitoris. This can cause accumulation of desquamated epithelial cells under the prepuce, resulting in the formation of smegmatic pseudocysts and keratin p…
View article: Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue
Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue Open
Our study suggests a potential benefit of ADT in male patients with early COVID-19 when the virus enters the nasopharynx, but not in those with advanced disease. The downregulation of viral entry proteins in the upper respiratory system fo…
View article: (085) Topical Capsaicin for Provoked Vestibulodynia
(085) Topical Capsaicin for Provoked Vestibulodynia Open
Introduction Provoked vestibulodynia (PVD), occurs when pain is localized in the vulvar vestibule and triggered by any vestibular contact (sexual or otherwise). PVD is the most common form of vulvodynia and there is currently no approved t…
View article: (031) Update from the Female Genitopelvic Pain Subcommittee of the International Consultation of Sexual Medicine on a systematic review of the efficacy and safety of treatments for vulvodynia
(031) Update from the Female Genitopelvic Pain Subcommittee of the International Consultation of Sexual Medicine on a systematic review of the efficacy and safety of treatments for vulvodynia Open
Introduction Literature on vulvodynia treatment is heterogeneous regarding intervention type and study quality. A recently published systematic review (SR) of treatments focusing on randomized controlled trials (RCTs) and non-RCTs for prov…
View article: Symptoms and associated impact in pre- and postmenopausal women with sexual arousal disorder: a concept elicitation study
Symptoms and associated impact in pre- and postmenopausal women with sexual arousal disorder: a concept elicitation study Open
Background Approximately 26% of adult women in the United States suffer from female sexual arousal disorder (FSAD), yet little has been done to compare the experience of FSAD in pre- and postmenopausal women, which is critical to enhance t…
View article: Differentially Regulated miRNAs and Their Related Molecular Pathways in Lichen Sclerosus
Differentially Regulated miRNAs and Their Related Molecular Pathways in Lichen Sclerosus Open
Lichen sclerosus (LS) is a chronic inflammatory skin disorder with unknown pathogenesis. The aberrant expression of microRNAs (miRNAs) is considered to exert a crucial role in LS. We used the next-generation sequencing technology (RNASeq) …
View article: Presenting symptoms and diagnosis of vulvar lichen sclerosus in premenopausal women: a cross-sectional study
Presenting symptoms and diagnosis of vulvar lichen sclerosus in premenopausal women: a cross-sectional study Open
Objective: Characterize the presentation of vulvar lichen scleorsus (LS) among premenopausal women. Design: Cross-sectional study. Setting: An international web-based survey distributed on social media support groups and in two urban gynec…
View article: Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus
Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus Open
OBJECTIVE: To estimate the efficacy of fractionated carbon dioxide (CO 2 ) laser therapy for vulvar lichen sclerosus. METHODS: We conducted a prospective, double-blind, randomized, sham-controlled, trial conducted in a clinic specializing …
View article: Reactive non-sexually related acute genital ulcers associated with COVID-19
Reactive non-sexually related acute genital ulcers associated with COVID-19 Open
Acute genital ulcers (AGU), known as Lipschütz ulcers, are painful vulvar ulcers typically affecting non-sexually active girls and women. AGU have been associated with viral infections, namely, Epstein-Barr virus (EBV). Here, we describe a…
View article: International Society for the Study of Women’s Sexual Health (ISSWSH) Review of Epidemiology and Pathophysiology, and a Consensus Nomenclature and Process of Care for the Management of Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD)
International Society for the Study of Women’s Sexual Health (ISSWSH) Review of Epidemiology and Pathophysiology, and a Consensus Nomenclature and Process of Care for the Management of Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD) Open
We provide, for the first time, an expert consensus review of the epidemiology and pathophysiology and the development of a new nomenclature and rational algorithm for management of this extremely distressing sexual health condition that m…
View article: Dr Eric L. Friedland z’l
Dr Eric L. Friedland z’l Open
Eric Friedland was born in New York City in 1941. Soon after birth it was found he had defective hearing and his mother faced hardship as his father left home six months later. His mother moved to Boston to be near relatives. She made the …
View article: Fractional CO2 Laser for the Treatment of Vulvar Lichen Sclerosus: a Double-Blind, Sham-Controlled Randomized Trial
Fractional CO2 Laser for the Treatment of Vulvar Lichen Sclerosus: a Double-Blind, Sham-Controlled Randomized Trial Open
Objective To determine the efficacy of fractional carbon dioxide laser (FXCO2) therapy for vulvar lichen sclerosus (VLS). Design Prospective, double-blind, sham-controlled, randomized trial. Setting Clinic specializing in vulvovaginal diso…