Todd Gress
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View article: Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder
Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder Open
Importance Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the …
View article: <i>GLP1R</i> Gene Expression and Kidney Disease Progression
<i>GLP1R</i> Gene Expression and Kidney Disease Progression Open
Importance Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have nephroprotective properties beyond those related to weight loss and glycemic control. Objective To investigate the association of genetically proxied GLP-1RAs with ki…
View article: Genetically predicted lipoprotein(a) associates with coronary artery plaque severity independent of low-density lipoprotein cholesterol
Genetically predicted lipoprotein(a) associates with coronary artery plaque severity independent of low-density lipoprotein cholesterol Open
Aims Elevated lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease, but the mechanisms of risk are debated. Studies have found inconsistent associations between Lp(a) and measurements of atherosclerosis…
View article: Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans
Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans Open
Background Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as risk for Alzheimer’s disease and related dementias (ADRD). Overlapping symptom profiles o…
View article: Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy Open
The Phenome-Wide Association Study (PheWAS) is increasingly used to broadly screen for potential treatment effects, e.g., IL6R variant as a proxy for IL6R antagonists. This approach offers an opportunity to address the limited power in cli…
View article: Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk
Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk Open
Importance Clinical trial data have called into question the efficacy of thiazide diuretics for the prevention of kidney stones. Objective To identify whether there is an association between genetic proxies of thiazide diuretics and the ri…
View article: Profiling of Non-Coding Regulators and Their Targets in Epicardial Fat from Patients with Coronary Artery Disease
Profiling of Non-Coding Regulators and Their Targets in Epicardial Fat from Patients with Coronary Artery Disease Open
Epicardial fat is a continuously growing target of investigation in cardiovascular diseases due to both its anatomical proximity to the heart and coronary circulation and its unique physiology among adipose depots. Previous reports have de…
View article: Dual role for angiotensin‐converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat
Dual role for angiotensin‐converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat Open
Summary Angiotensin‐converting enzyme 2 (ACE2) has been an increasingly prevalent target for investigation since its discovery 20 years ago. The finding that it serves a counterregulatory function within the traditional renin–angiotensin s…
View article: Relationship between dietary sodium and sugar intake: A cross‐sectional study of the National Health and Nutrition Examination Survey 2001‐2016
Relationship between dietary sodium and sugar intake: A cross‐sectional study of the National Health and Nutrition Examination Survey 2001‐2016 Open
Dietary sodium intake and cardiovascular outcomes have a reported J‐shaped curve relationship. This study analyzes the relationship between dietary sodium and sugar intake as a potential mechanism to explain this association. The authors e…
View article: Postpartum Opioid Use Following Vaginal Deliveries with No or Minor Obstetric Perineal Lacerations
Postpartum Opioid Use Following Vaginal Deliveries with No or Minor Obstetric Perineal Lacerations Open
Background
\nRecommendations for the management of pain following vaginal delivery are not specific and do
\nnot differentiate patients based on the degree of perineal trauma. Our objective is to describe
\npatterns of postpartum opioid us…
View article: Potentially Avoidable Acute Care Patient Transfers to a Rural Academic Medical Center
Potentially Avoidable Acute Care Patient Transfers to a Rural Academic Medical Center Open
Though inter-facility acute care patient transfers from resource-limited rural hospitals are necessary, it is desirable to minimize them for several reasons. Some transfers might be potentially avoidable with appropriate pre-transfer telec…
View article: Implementation of Basal–Bolus Therapy in Type 2 Diabetes: A Randomized Controlled Trial Comparing Bolus Insulin Delivery Using an Insulin Patch with an Insulin Pen
Implementation of Basal–Bolus Therapy in Type 2 Diabetes: A Randomized Controlled Trial Comparing Bolus Insulin Delivery Using an Insulin Patch with an Insulin Pen Open
Background: Barriers to mealtime insulin include complexity, fear of injections, and lifestyle interference. This multicenter, randomized controlled trial evaluated efficacy, safety, and self-reported outcomes in adults with type 2 diabete…
View article: Antibiotic Prescriptions for Upper Respiratory Infections in a Pediatric Office Versus an Urgent Care Center
Antibiotic Prescriptions for Upper Respiratory Infections in a Pediatric Office Versus an Urgent Care Center Open
It is estimated that as many as 10 million unnecessary antibiotic prescriptions are written each year for children. Children are more likely to receive antibiotics for an upper respiratory infection in an urgent care center compared with t…
View article: Factors Associated with Functional Decline in Elderly Female Breast Cancer Patients in Appalachia
Factors Associated with Functional Decline in Elderly Female Breast Cancer Patients in Appalachia Open
Background Functional status has been previously shown in the elderly cancer population to predict both mortality as well as treatment tolerance. The goal of this study was to determine if there are certain subsets of the elderly breast ca…
View article: Laparoscopic vertical sleeve gastrectomy
Laparoscopic vertical sleeve gastrectomy Open
The aim of this study was to evaluate the outcomes after laparoscopic sleeve gastrectomy (SG) in a VA population.SG has recently gained popularity as a definitive bariatric surgery procedure. Data are lacking on long-term outcomes, particu…
View article: A Free Clinic Continuity Experience During Residency Is Associated With Practice in Underserved Areas
A Free Clinic Continuity Experience During Residency Is Associated With Practice in Underserved Areas Open
Background Exposure to underserved areas during training may increase residents' likelihood of practice in these settings. The Marshall University Family Medicine Residency offers a supplemental continuity experience at a local free clinic…