Todd Hoare
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View article: Injectable Dual‐Crosslinked Poly(oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration
Injectable Dual‐Crosslinked Poly(oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration Open
Traditional dermal wound closure methods, such as sutures and staples, are invasive, causing soft tissue trauma, increasing the likelihood of inflammation and infections. Alternatively, while existing tissue adhesives can seal and adhere t…
View article: Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies
Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies Open
Current anti‐fibrotic therapeutics for idiopathic pulmonary fibrosis (IPF) slow disease progression but are non‐curative and have systemic side effects, promoting interest in therapies that can repolarize macrophages away from their pro‐fi…
View article: Hydrazone-crosslinked poly(oligoethylene glycol methacrylate)-based hydrogels with physically entrapped phage effectively control Pseudomonas aeruginosa infections in a burn wound model
Hydrazone-crosslinked poly(oligoethylene glycol methacrylate)-based hydrogels with physically entrapped phage effectively control Pseudomonas aeruginosa infections in a burn wound model Open
First-line treatments for treating wound infections are under threat from the increase in antimicrobial resistant bacteria, a threat further exacerbated in burn wounds in which the immune response to the infection site is blocked by burned…
View article: β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery
β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery Open
Innate immune cells such as macrophages and dendritic cells play major roles in the progression of many cancerous, fibrotic, and autoimmune diseases, often due to environmental cues that skew these cells toward a phenotype that progresses …
View article: In Situ‐Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)‐Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing
In Situ‐Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)‐Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing Open
In situ‐gelling antibacterial hydrogels are reported in which two antibacterial entities (quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP)) are tethered to a single precursor based on the anti‐fouling polymer poly(oli…
View article: Electrochemical detection of Legionella pneumophila using DNAzymes and under continuous flow in cooling tower water
Electrochemical detection of Legionella pneumophila using DNAzymes and under continuous flow in cooling tower water Open
Rapid detection of Legionella pneumophila in cooling tower water is crucial to mitigate the fatal consequences of Legionnaires disease. This study presents a microfluidic system that employs RNA-cleaving DNAzymes (RCDs) for continuous real…
View article: Investigation of the mesencephalic astrocyte-derived neurotrophic factor–endoplasmic reticulum stress pathway in mood disorders
Investigation of the mesencephalic astrocyte-derived neurotrophic factor–endoplasmic reticulum stress pathway in mood disorders Open
Background Bipolar disorder (BD) has been associated with impaired cellular resilience. Recent studies have shown abnormalities in the unfolded protein response (UPR) in BD. The UPR is the cellular response to endoplasmic reticulum (ER) st…
View article: Data-driven optimization of nanoparticle size using the prediction reliability enhancing parameter (PREP)
Data-driven optimization of nanoparticle size using the prediction reliability enhancing parameter (PREP) Open
A data-driven method (PREP) enables precise control of nanoparticle size using minimal experimental iterations, offering a new pathway for rapid nanomaterial optimization.
View article: Nose-to-brain delivery of lithium via a sprayable in situ-forming hydrogel composed of chelating starch nanoparticles
Nose-to-brain delivery of lithium via a sprayable in situ-forming hydrogel composed of chelating starch nanoparticles Open
While bipolar disorder patients can benefit from lithium therapy, high levels of lithium in the serum can induce undesirable systemic side effects. Intranasal (IN) lithium delivery offers a potential solution to this challenge given its po…
View article: Modulating pro-fibrotic macrophages using yeast beta-glucan microparticles prepared by Pressurized Gas eXpanded liquid (PGX) Technology®
Modulating pro-fibrotic macrophages using yeast beta-glucan microparticles prepared by Pressurized Gas eXpanded liquid (PGX) Technology® Open
Pro-fibrotic M2-like macrophages are widely implicated in the pathogenesis and progression of lung fibrosis due to their production of pro-fibrotic growth factors and cytokines. Yeast beta-glucan (YBG) microparticles have shown potential a…
View article: In situ-gelling hydrophobized starch nanoparticle-based nanoparticle network hydrogels for the effective delivery of intranasal olanzapine to treat brain disorders
In situ-gelling hydrophobized starch nanoparticle-based nanoparticle network hydrogels for the effective delivery of intranasal olanzapine to treat brain disorders Open
Intranasal (IN) delivery offers potential to deliver antipsychotic drugs with improved efficacy to the brain. However, the solubilization of such drugs and the frequency of required re-application both represent challenges to its practical…
View article: Injectable and Dynamically Crosslinked Zwitterionic Hydrogels for Anti‐Fouling and Tissue Regeneration Applications
Injectable and Dynamically Crosslinked Zwitterionic Hydrogels for Anti‐Fouling and Tissue Regeneration Applications Open
A zwitterionic injectable and degradable hydrogel based on hydrazide and aldehyde‐functionalized [2‐(methacryloyloxy)ethyl] dimethyl‐(3‐sulfopropyl)ammonium hydroxide (DMAPS) precursor polymers that can address practical in vivo needs is r…
View article: Anti‐Fouling Polymer or Peptide‐Modified Electrochemical Biosensors for Improved Biosensing in Complex Media
Anti‐Fouling Polymer or Peptide‐Modified Electrochemical Biosensors for Improved Biosensing in Complex Media Open
Electrochemical biosensing represents a highly effective technology for detecting disease biomarkers given its high sensitivity, low and clinically relevant limit of detection, and cost effectiveness. However, in complex media such as urin…
View article: The effect of comb length on the <i>in vitro</i> and <i>in vivo</i> properties of self-assembled poly(oligoethylene glycol methacrylate)-based block copolymer nanoparticles
The effect of comb length on the <i>in vitro</i> and <i>in vivo</i> properties of self-assembled poly(oligoethylene glycol methacrylate)-based block copolymer nanoparticles Open
Comb copolymer analogues of poly(lactic acid)-polyethylene glycol block copolymers (PLA- b -PEG) offer potential to overcome the inherent chemistry and stability limitations of their linear block copolymer counterparts.
View article: Overview of methods and considerations for the photodynamic inactivation of microorganisms for agricultural applications
Overview of methods and considerations for the photodynamic inactivation of microorganisms for agricultural applications Open
Antimicrobial resistance in agriculture is a global concern and carries huge financial consequences. Despite that, practical solutions for growers that are sustainable, low cost and environmentally friendly have been sparse. This has creat…
View article: Multicellular Layered Nanofibrous Poly(Oligo Ethylene Glycol Methacrylate) (POEGMA)‐Based Hydrogel Scaffolds via Reactive Cell Electrospinning
Multicellular Layered Nanofibrous Poly(Oligo Ethylene Glycol Methacrylate) (POEGMA)‐Based Hydrogel Scaffolds via Reactive Cell Electrospinning Open
While hydrogels are demonstrated to be effective scaffolds for soft tissue engineering, existing fabrication techniques pose limitations in terms of being able to reproduce both the micro/nanofibrous structures of native extracellular matr…
View article: The bending rigidity of the red blood cell cytoplasmic membrane
The bending rigidity of the red blood cell cytoplasmic membrane Open
An important mechanical property of cells is the membrane bending modulus, κ . In the case of red blood cells (RBCs) there is a composite membrane consisting of a cytoplasmic membrane and an underlying spectrin network. Literature values o…
View article: Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation
Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation Open
Graphical Abstract
View article: Incorporation of Polymer-Grafted Cellulose Nanocrystals into Latex-Based Pressure-Sensitive Adhesives
Incorporation of Polymer-Grafted Cellulose Nanocrystals into Latex-Based Pressure-Sensitive Adhesives Open
While the improvement of water-based adhesives with renewable additives is important as industry shifts toward more sustainable practices, a complete understanding of how the compatibility between additives and polymers affects adhesive pe…
View article: Gravity steam reprocessing in healthcare facilities for the reuse of N95 respirators
Gravity steam reprocessing in healthcare facilities for the reuse of N95 respirators Open
The gravity steam method can effectively reprocess N95 respirators over at least three reprocessing cycles without negatively impacting the functionality requirements set out by regulators. Enabling the reuse of N95 respirators is a crucia…
View article: Single-Step Reactive Electrospinning of Cell-Loaded Nanofibrous Scaffolds as Ready-to-Use Tissue Patches
Single-Step Reactive Electrospinning of Cell-Loaded Nanofibrous Scaffolds as Ready-to-Use Tissue Patches Open
A reactive electrospinning strategy is used to fabricate viable and proliferative cell-loaded nanofibrous hydrogel scaffolds in a single step using an all-aqueous approach. In situ gelling and degradable hydrazone-cross-linked poly(oligo e…
View article: Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning Open
While various smart materials have been explored for a variety of biomedical applications (e.g., drug delivery, tissue engineering, bioimaging, etc.), their ultimate clinical use has been hampered by the lack of biologically-relevant degra…
View article: A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors
A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors Open
A significant problem in high-throughput drug screening is the disproportionate number of false hits associated with drug candidates that form colloidal aggregates. Such molecules, referred to as promiscuous inhibitors, nonspecifically inh…
View article: Macroporous Hydrogels: Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities (Adv. Healthcare Mater. 1/2018)
Macroporous Hydrogels: Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities (Adv. Healthcare Mater. 1/2018) Open
Structured macroporous hydrogels offer both the swelling and interfacial properties of bulk hydrogels as well as the transport properties of “hard” macroporous materials, making these networks intriguing for many biomedical applications. I…
View article: Injectable Anisotropic Nanocomposite Hydrogels Direct in Situ Growth and Alignment of Myotubes
Injectable Anisotropic Nanocomposite Hydrogels Direct in Situ Growth and Alignment of Myotubes Open
While injectable in situ cross-linking hydrogels have attracted increasing attention as minimally invasive tissue scaffolds and controlled delivery systems, their inherently disorganized and isotropic network structure limits their utility…