Todd J. Anderson
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View article: Characterization of lipoprotein (a) testing in Alberta, Canada: a retrospective cohort study
Characterization of lipoprotein (a) testing in Alberta, Canada: a retrospective cohort study Open
Individuals with elevated Lp(a) levels and prior ASCVD had numerically greater HCRU/costs and subsequent MACE rates. Understanding of the characteristics and outcomes in the context of ASCVD status is important to develop risk assessment a…
View article: Cholesterol Levels and Cardiovascular Outcomes Following Statin Initiation for Primary Prevention
Cholesterol Levels and Cardiovascular Outcomes Following Statin Initiation for Primary Prevention Open
These findings support the residual risk associated with incompletely controlled LDL-C or non-HDL-C levels after statin initiation for primary prevention.
View article: Ferritin and transferrin predict common carotid intima-media thickness in females: a machine-learning informed individual participant data meta-analysis
Ferritin and transferrin predict common carotid intima-media thickness in females: a machine-learning informed individual participant data meta-analysis Open
Background Iron overload promotes atherosclerosis in mice and causes vascular dysfunction in humans with Hemochromatosis. However, data are controversial on whether systemic iron availability within physiological limits affects the pathoge…
View article: Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima‐Media Thickness: An Individual Participant Data Meta‐Analysis
Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima‐Media Thickness: An Individual Participant Data Meta‐Analysis Open
Background The major risk factors for atherosclerotic cardiovascular disease differ by race or ethnicity but have largely been defined using populations of European ancestry. Despite the rising prevalence of cardiovascular disease in Afric…
View article: Emergency department visits and hospitalizations after a diagnosis of angina with no obstructive coronary artery disease (ANOCA)
Emergency department visits and hospitalizations after a diagnosis of angina with no obstructive coronary artery disease (ANOCA) Open
ED visits for ANOCA have risen over time while hospitalizations remain stable, indicating a growing burden despite generally lower rates than SA with obstructive CAD. These findings underscore the need for more effective management strateg…
View article: The Use of Glucagon-Like Peptide-1 (GLP-1) Agonists in the Perioperative Period: A Case Study
The Use of Glucagon-Like Peptide-1 (GLP-1) Agonists in the Perioperative Period: A Case Study Open
View article: Unveiling a Large Pelvic Mass in a Middle-Aged Woman: The Consequences of Neglected Gynecological Care
Unveiling a Large Pelvic Mass in a Middle-Aged Woman: The Consequences of Neglected Gynecological Care Open
Pelvic masses in women can originate from both gynecological and non-gynecological sources, necessitating careful evaluation to ensure appropriate treatment. Gynecological masses can range from functional ovarian cysts and tubo-ovarian abs…
View article: Hidden Rhythms: A Complex Case of Hyperemesis Gravidarum-Induced Arrhythmias
Hidden Rhythms: A Complex Case of Hyperemesis Gravidarum-Induced Arrhythmias Open
Hyperemesis gravidarum (HG) is a severe condition marked by intense nausea and vomiting during pregnancy, which is different from typical morning sickness. It is marked by weight loss exceeding 5% of pre-pregnancy weight, ketonuria, dehydr…
View article: Intersecting Pathologies: Vulvar Cancer Complicated by a Fusobacterium necrophorum Infection
Intersecting Pathologies: Vulvar Cancer Complicated by a Fusobacterium necrophorum Infection Open
Vulvar cancer represents a small minority of annual cancer cases in America. This malignancy affects more than the physical health of the patient. This malignancy also has a negative impact on women's psychological and sexual health. This …
View article: Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights
Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights Open
Metformin is an orally effective anti-hyperglycemic drug that despite being introduced over 60 years ago is still utilized by an estimated 120 to 150 million people worldwide for the treatment of type 2 diabetes (T2D). Metformin is used of…
View article: Evaluating Readability, Understandability, and Actionability of Online Printable Patient Education Materials for Cholesterol Management: A Systematic Review
Evaluating Readability, Understandability, and Actionability of Online Printable Patient Education Materials for Cholesterol Management: A Systematic Review Open
Background Dyslipidemia management is a cornerstone in cardiovascular disease prevention and relies heavily on patient adherence to lifestyle modifications and medications. Numerous cholesterol patient education materials are available onl…
View article: Heterogeneity of coronary vascular function and myocardial oxygenation in women with angina and non-obstructive coronary artery disease
Heterogeneity of coronary vascular function and myocardial oxygenation in women with angina and non-obstructive coronary artery disease Open
Aims Women with angina and non-obstructive coronary artery disease (ANOCA) have a heightened risk for cardiovascular events, and the pathophysiology for ischaemic symptoms may be related to alterations in microvascular structure and functi…
View article: Editors’ highlight picks from 2023 in <i>EHJ Open</i>
Editors’ highlight picks from 2023 in <i>EHJ Open</i> Open
peer reviewed
View article: Validation of the European SCORE2 models in a Canadian primary care cohort
Validation of the European SCORE2 models in a Canadian primary care cohort Open
Aims Systematic Coronary Risk Evaluation Model 2 (SCORE2) was recently developed to predict atherosclerotic cardiovascular disease (ASCVD) in Europe. Whether these models could be used outside of Europe is not known. The objective of this …
View article: Temporal trends and predictors of emergency department visits and hospital readmissions in angina and no obstructive coronary artery disease (ANOCA): a population-based study of 85,573 adults
Temporal trends and predictors of emergency department visits and hospital readmissions in angina and no obstructive coronary artery disease (ANOCA): a population-based study of 85,573 adults Open
Background Chest pain in patients with angina and no obstructive coronary artery disease (ANOCA) is a diagnostic and treatment challenge, resulting in a significant burden on healthcare resources. With increasing recognition of ANOCA, it i…
View article: Chest Pain Evaluation: Diagnostic Testing
Chest Pain Evaluation: Diagnostic Testing Open
View article: Temporal trends and factors associated with emergency department visits and hospitalizations in angina with no obstructive coronary artery disease (ANOCA)
Temporal trends and factors associated with emergency department visits and hospitalizations in angina with no obstructive coronary artery disease (ANOCA) Open
Introduction Angina with no obstructive coronary artery disease (ANOCA) presents diagnostic and treatment challenges, significantly burdening healthcare resources as reported in previous studies. This study assessed temporal changes in eme…
View article: Factors associated with recovery from stunting at 24 months of age among infants and young children enrolled in the Pediatric Development Clinic (PDC): A retrospective cohort study in rural Rwanda
Factors associated with recovery from stunting at 24 months of age among infants and young children enrolled in the Pediatric Development Clinic (PDC): A retrospective cohort study in rural Rwanda Open
Introduction Stunting (low height/length-for-age) in early life is associated with poor long-term health and developmental outcomes. Nutrition interventions provided during the first 1,000 days of life can result in improved catch-up growt…
View article: Trends in Major Adverse Cardiac Events and Healthcare Resource Utilization During the COVID-19 Pandemic in Alberta, Canada
Trends in Major Adverse Cardiac Events and Healthcare Resource Utilization During the COVID-19 Pandemic in Alberta, Canada Open
View article: Correction to: Guideline LDL-C Threshold Achievement in Acute Myocardial Infarction Patients: A Real-World Evidence Study Demonstrating the Impact of Treatment Intensification with PCSK9i
Correction to: Guideline LDL-C Threshold Achievement in Acute Myocardial Infarction Patients: A Real-World Evidence Study Demonstrating the Impact of Treatment Intensification with PCSK9i Open
View article: Development and validation of echocardiography-based machine-learning models to predict mortality
Development and validation of echocardiography-based machine-learning models to predict mortality Open
Funding for Alberta HEART was provided by an Alberta Innovates - Health Solutions Interdisciplinary Team Grant no. AHFMRITG 200801018. P.K. holds a Canadian Institutes of Health Research (CIHR) Sex and Gender Science Chair and a Heart & St…
View article: Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum
Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum Open
The data herein establish the theoretical framework for integrating discrete strain components into volumetric measurements across the cardiac cycle, and highlight the potential benefit of this approach for differentiating patients along t…
View article: Guideline LDL-C Threshold Achievement in Acute Myocardial Infarction Patients: A Real-World Evidence Study Demonstrating the Impact of Treatment Intensification with PCSK9i
Guideline LDL-C Threshold Achievement in Acute Myocardial Infarction Patients: A Real-World Evidence Study Demonstrating the Impact of Treatment Intensification with PCSK9i Open
Intensification with PCSK9i in AMI patients results in a greater proportion of patients achieving below the recommended LDL-C threshold versus statins and or ezetimibe alone. Increased focus on achieving below the LDL-C thresholds with add…
View article: Table of Contents
Table of Contents Open
View article: Toward the Advanced Manufacturing of Land-Based Wind Turbine Blades: Preprint
Toward the Advanced Manufacturing of Land-Based Wind Turbine Blades: Preprint Open
The National Renewable Energy Laboratory (NREL) and General Electric (GE) are partners within the Additive and Modular Enabled Rotor Blades and Integrated Composites Assembly (AMERICA) project. AMERICA aims to develop advanced manufacturin…
View article: Magnetic Resonance Imaging of Intraplaque Hemorrhage and Plaque Lipid Content With Continued Lipid-Lowering Therapy: Results of a Magnetic Resonance Imaging Substudy in AIM-HIGH
Magnetic Resonance Imaging of Intraplaque Hemorrhage and Plaque Lipid Content With Continued Lipid-Lowering Therapy: Results of a Magnetic Resonance Imaging Substudy in AIM-HIGH Open
Background: Intraplaque hemorrhage (IPH) is associated with plaque progression and ischemic events, and plaque lipid content (% lipid core) predicts the residual atherosclerotic cardiovascular disease risk. This study examined the impact o…
View article: Limits of Cardiovascular Adaptation During an Extreme Ultramarathon
Limits of Cardiovascular Adaptation During an Extreme Ultramarathon Open
Extreme endurance athletic challenges provide unique opportunities to study the cardiovascular system's capacity for structural, functional, and hemodynamic adaptation. The authors present a case of a male subject who ran 2,469 km, with se…
View article: Characteristics and clinical outcomes of patients presenting with advanced HIV disease in the “treat all” era: a retrospective cohort study from rural Rwanda
Characteristics and clinical outcomes of patients presenting with advanced HIV disease in the “treat all” era: a retrospective cohort study from rural Rwanda Open
View article: Repurposing Metformin for Vascular Disease
Repurposing Metformin for Vascular Disease Open
Metformin has been used as an oral anti-hyperglycaemic drug since the late 1950s; however, following the release in 1998 of the findings of the 20-year United Kingdom Prospective Diabetes Study (UKPDS), metformin use rapidly increased and …
View article: Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima‐Media Thickness: An Individual Participant Data Meta‐Analysis
Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima‐Media Thickness: An Individual Participant Data Meta‐Analysis Open
Background The major risk factors for atherosclerotic cardiovascular disease differ by race or ethnicity but have largely been defined using populations of European ancestry. Despite the rising prevalence of cardiovascular disease in Afric…