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View article: Experimental evolution of gene essentiality in bacteria
Experimental evolution of gene essentiality in bacteria Open
Essential gene products carry out fundamental cellular activities in interaction with other components. However, the lack of essential gene mutants and appropriate methodologies to link essential gene functions with their partners poses si…
View article: Characterization of a heme-degrading enzyme that mediates fitness and pathogenicity in <i>Enterococcus faecalis</i>
Characterization of a heme-degrading enzyme that mediates fitness and pathogenicity in <i>Enterococcus faecalis</i> Open
Enterococcus faecalis , a gut commensal, is a leading cause of opportunistic infections. Its virulence is linked to its ability to thrive in hostile environments, which includes host-imposed metal starvation. We recently showed that E. fae…
View article: A Novel Heme-Degrading Enzyme that Regulates Heme and Iron Homeostasis and Promotes Virulence in <i>Enterococcus faecalis</i>
A Novel Heme-Degrading Enzyme that Regulates Heme and Iron Homeostasis and Promotes Virulence in <i>Enterococcus faecalis</i> Open
Enterococcus faecalis , a gut commensal, is a leading cause of opportunistic infections. Its virulence is linked to its ability to thrive in hostile environments, which includes host-imposed metal starvation. We recently showed that E. fae…
View article: Glycerol metabolism contributes to competition by oral streptococci through production of hydrogen peroxide
Glycerol metabolism contributes to competition by oral streptococci through production of hydrogen peroxide Open
As a biological byproduct from both humans and microbes, glycerol’s contribution to microbial homeostasis in the oral cavity remains understudied. In this study, we examined glycerol metabolism by Streptococcus sanguinis, a commensal assoc…
View article: Experimental evolution of gene essentiality in bacteria
Experimental evolution of gene essentiality in bacteria Open
Essential gene products carry out fundamental cellular activities in interaction with other components. However, the lack of essential gene mutants and appropriate methodologies to link essential gene functions with their partners poses si…
View article: A novel infective endocarditis virulence factor related to multiple functions for bacterial survival in blood was discovered in<i>Streptococcus sanguinis</i>
A novel infective endocarditis virulence factor related to multiple functions for bacterial survival in blood was discovered in<i>Streptococcus sanguinis</i> Open
We identified the role of a conserved hypothetical protein (SSA_0451) in S. sanguinis that is involved in the virulence of infective endocarditis. An in vitro whole blood killing assay and rabbit endocarditis model studies revealed that th…
View article: Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen Peroxide
Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen Peroxide Open
As a biological byproduct from both humans and microbes, glycerol’s contribution to microbial homeostasis in the oral cavity remains understudied. Here we examined glycerol metabolism by Streptococcus sanguinis, a commensal associated with…
View article: Viability of bacteria associated with root caries after Nd:YAG laser application in combination with variousantimicrobial agents: An in vitro study
Viability of bacteria associated with root caries after Nd:YAG laser application in combination with variousantimicrobial agents: An in vitro study Open
The Nd:YAG laser combined with 0.5% NaOCl resulted in the most substantial reduction in bacterial survival as compared to the antimicrobials or the Nd:YAG laser used alone.
View article: The In Vitro Effect of Laser Irradiation (Er:YAG and CO2) and Chemical Reagents (Hydrogen Peroxide, Sodium Hypochlorite, Chlorhexidine, or Sodium Fluoride) Alone or in Combination on Reducing Root Caries Bacteria
The In Vitro Effect of Laser Irradiation (Er:YAG and CO2) and Chemical Reagents (Hydrogen Peroxide, Sodium Hypochlorite, Chlorhexidine, or Sodium Fluoride) Alone or in Combination on Reducing Root Caries Bacteria Open
(1) Lasers have been used for the treatment of dentinal hypersensitivity and bacterial reductions in periodontology. The purpose of this in vitro study was to evaluate the effect of Carbon Dioxide (CO2) and Erbium-doped Yttrium Aluminum Ga…
View article: Peracetic Acid: A Practical Alternative to Formalin for Disinfection of Extracted Human Teeth
Peracetic Acid: A Practical Alternative to Formalin for Disinfection of Extracted Human Teeth Open
Extracted human teeth provide the closest approximation to teeth in situ and play important roles in dental education and materials research. Since extracted teeth are potentially infectious, the Centers for Disease Control recommend their…
View article: Contribution of a ZIP‐family protein to manganese uptake and infective endocarditis virulence in <i>Streptococcus sanguinis</i>
Contribution of a ZIP‐family protein to manganese uptake and infective endocarditis virulence in <i>Streptococcus sanguinis</i> Open
Streptococcus sanguinis is an important cause of infective endocarditis. In strain SK36, the ABC‐family manganese transporter, SsaACB, is essential for virulence. We have now identified a ZIP‐family protein, TmpA, as a secondary manganese …
View article: Manganese transport by <i>Streptococcus sanguinis</i> in acidic conditions and its impact on growth <i>in vitro</i> and <i>in vivo</i>
Manganese transport by <i>Streptococcus sanguinis</i> in acidic conditions and its impact on growth <i>in vitro</i> and <i>in vivo</i> Open
Summary Streptococcus sanguinis is an oral commensal and an etiological agent of infective endocarditis. Previous studies have identified the SsaACB manganese transporter as essential for endocarditis virulence; however, the significance o…
View article: Contribution of metal transporters of the ABC, ZIP, and NRAMP families to manganese uptake and infective endocarditis virulence in <i>Streptococcus sanguinis</i>
Contribution of metal transporters of the ABC, ZIP, and NRAMP families to manganese uptake and infective endocarditis virulence in <i>Streptococcus sanguinis</i> Open
Summary Streptococcus sanguinis is an important cause of infective endocarditis. In strain SK36, the ABC-family manganese transporter, SsaACB, is essential for virulence. We have now identified a ZIP-family protein, TmpA, as a secondary ma…
View article: A novel sialic acid-binding adhesin present in multiple species contributes to the pathogenesis of Infective endocarditis
A novel sialic acid-binding adhesin present in multiple species contributes to the pathogenesis of Infective endocarditis Open
Bacterial binding to platelets is a key step in the development of infective endocarditis (IE). Sialic acid, a common terminal carbohydrate on host glycans, is the major receptor for streptococci on platelets. So far, all defined interacti…
View article: Manganese Depletion Leads to Multisystem Changes in the Transcriptome of the Opportunistic Pathogen Streptococcus sanguinis
Manganese Depletion Leads to Multisystem Changes in the Transcriptome of the Opportunistic Pathogen Streptococcus sanguinis Open
Streptococcus sanguinis is a primary colonizer of teeth and is typically considered beneficial due to its antagonistic relationship with the cariogenic pathogen Streptococcus mutans. However, S. sanguinis can also act as an opportunistic p…
View article: Genome‐wide identification of <i>Streptococcus sanguinis</i> fitness genes in human serum and discovery of potential selective drug targets
Genome‐wide identification of <i>Streptococcus sanguinis</i> fitness genes in human serum and discovery of potential selective drug targets Open
Streptococcus sanguinis is a primary colonizer of teeth and is associated with oral health. When it enters the bloodstream, however, this bacterium may cause the serious illness infective endocarditis. The genes required for survival and p…
View article: Time-course analysis of<i>Streptococcus sanguinis</i>after manganese depletion reveals changes in glycolytic, nucleotide, and redox metabolites
Time-course analysis of<i>Streptococcus sanguinis</i>after manganese depletion reveals changes in glycolytic, nucleotide, and redox metabolites Open
Introduction Manganese is important for the endocarditis pathogen, Streptococcus sanguinis . Little is known about why manganese is required for virulence or how it impacts the metabolome of streptococci. Objectives We applied untargeted m…
View article: Fermentor Growth of Streptococcus sanguinis v1
Fermentor Growth of Streptococcus sanguinis v1 Open
Streptococcus sanguinis is a lactic acid-forming bacterium that can be cultured in both aerobic and anaerobic conditions. It is a primary colonizer of the oral cavity but can also cause a heart disease called infective endocarditis. Our ma…
View article: Manganese depletion leads to multisystem changes in the transcriptome of the opportunistic pathogen <i>Streptococcus sanguinis</i>
Manganese depletion leads to multisystem changes in the transcriptome of the opportunistic pathogen <i>Streptococcus sanguinis</i> Open
1 Abstract Streptococcus sanguinis is a primary tooth colonizer and is typically considered beneficial due to its antagonistic relationship with the cariogenic pathogen Streptococcus mutans . However, S. sanguinis can also act as an opport…
View article: Intracellular Metal Speciation in <i>Streptococcus sanguinis</i> Establishes SsaACB as Critical for Redox Maintenance
Intracellular Metal Speciation in <i>Streptococcus sanguinis</i> Establishes SsaACB as Critical for Redox Maintenance Open
Streptococcus sanguinis is an oral commensal bacterium, but it can colonize pre-existing heart valve vegetations if introduced into the bloodstream, leading to infective endocarditis. Loss of Mn- or Fe-cofactored virulence determinants are…
View article: Genomic, Phenotypic, and Virulence Analysis of <i>Streptococcus sanguinis</i> Oral and Infective-Endocarditis Isolates
Genomic, Phenotypic, and Virulence Analysis of <i>Streptococcus sanguinis</i> Oral and Infective-Endocarditis Isolates Open
Streptococcus sanguinis , an abundant and benign inhabitant of the oral cavity, is an important etiologic agent of infective endocarditis (IE), particularly in people with predisposing cardiac valvular damage. Although commonly isolated fr…
View article: Manganese acquisition is essential for virulence of Enterococcus faecalis
Manganese acquisition is essential for virulence of Enterococcus faecalis Open
Manganese (Mn) is an essential micronutrient that is not readily available to pathogens during infection due to an active host defense mechanism known as nutritional immunity. To overcome this nutrient restriction, bacteria utilize high-af…
View article: <i>Streptococcus Sanguinis</i> Biofilm Formation & Interaction with Oral Pathogens
<i>Streptococcus Sanguinis</i> Biofilm Formation & Interaction with Oral Pathogens Open
Caries and periodontitis are the two most common human dental diseases and are caused by dysbiosis of oral flora. Although commensal microorganisms have been demonstrated to protect against pathogens and promote oral health, most previous …
View article: Manganese acquisition is essential for virulence of<i>Enterococcus faecalis</i>
Manganese acquisition is essential for virulence of<i>Enterococcus faecalis</i> Open
Manganese (Mn) is an essential micronutrient that is not readily available to pathogens during infection due to an active host defense mechanism known as nutritional immunity. To overcome this nutrient restriction, bacteria utilize high-af…
View article: Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis
Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis Open
The paradoxical response of Streptococcus sanguinis to drugs prescribed for dental and clinical practices has complicated treatment guidelines and raised the need for further investigation. We conducted a high throughput study on concomita…
View article: ciaR impacts biofilm formation by regulating an arginine biosynthesis pathway in Streptococcus sanguinis SK36
ciaR impacts biofilm formation by regulating an arginine biosynthesis pathway in Streptococcus sanguinis SK36 Open
Streptococcus sanguinis is an early colonizer of the tooth surface and competes with oral pathogens such as Streptococcus mutans to maintain oral health. However, little is known about its mechanism of biofilm formation. Here, we show that…
View article: Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation
Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation Open
Biofilm accounts for 65–80 % of microbial infections in humans. Considerable evidence links biofilm formation by oral microbiota to oral disease and consequently systemic infections. Streptococcus sanguinis , a Gram-positive bacterium, is …
View article: Issue Information – TOC
Issue Information – TOC Open
Part A is an international, interdisciplinary, Englishlanguage publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical …