Todd Lenz
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View article: A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death
The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death Open
Programmed-cell death is an antimicrobial defense mechanism that promotes clearance of intracellular pathogens. Toxoplasma counteracts host immune defenses by secreting effector proteins into host cells; however, how the parasite evades ly…
View article: PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum
PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum Open
The environmental challenges the human malaria parasite, Plasmodium falciparum , faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regul…
View article: PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum
PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum Open
The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regula…
View article: Insights into the evolution, virulence and speciation of <i>Babesia MO1</i> and <i>Babesia divergens</i> through multiomics analyses
Insights into the evolution, virulence and speciation of <i>Babesia MO1</i> and <i>Babesia divergens</i> through multiomics analyses Open
Babesiosis, caused by protozoan parasites of the genus Babesia, is an emerging tick-borne disease of significance for both human and animal health. Babesia parasites infect erythrocytes of vertebrate hosts where they develop and multiply r…
View article: Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum
Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum Open
Plasmodium falciparum is responsible for what appears to be a never-ending public health issue in the developing world. With repeated infections, a gradual semi-immunity to severe malaria can be acquired but this is disrupted when women be…
View article: Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum
Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum Open
Plasmodium falciparum is responsible for what appears to be a never-ending public health issue in the developing world. With repeated infections, a gradual semi-immunity to severe malaria can be acquired but this is disrupted when women be…
View article: Chromatin structure and<i>var2csa</i>– a tango in regulation of<i>var</i>gene expression in the human malaria parasite,<i>Plasmodium falciparum</i>?
Chromatin structure and<i>var2csa</i>– a tango in regulation of<i>var</i>gene expression in the human malaria parasite,<i>Plasmodium falciparum</i>? Open
Over the last few decades, novel methods have been developed to study how chromosome positioning within the nucleus may play a role in gene regulation. Adaptation of these methods in the human malaria parasite, Plasmodium falciparum , has …
View article: Multiomics analysis reveals<i>B.</i>MO1 as a distinct<i>Babesia</i>species and provides insights into its evolution and virulence
Multiomics analysis reveals<i>B.</i>MO1 as a distinct<i>Babesia</i>species and provides insights into its evolution and virulence Open
Babesiosis, caused by protozoan parasites of the genus Babesia , is an emerging tick-borne disease of significance for both human and animal health. Babesia parasites infect erythrocytes of vertebrate hosts where they develop and multiply …
View article: Author Response: PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum
Author Response: PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum Open
The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regula…
View article: PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum
PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum Open
The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regula…
View article: PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum
PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum Open
The environmental challenges the human malaria parasite, Plasmodium falciparum , faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regul…
View article: Reviewer #1 (Public Review): PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum
Reviewer #1 (Public Review): PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum Open
The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regula…
View article: Reviewer #2 (Public Review): PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum
Reviewer #2 (Public Review): PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum Open
The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regula…
View article: Epigenetics and chromatin structure regulate <i>var2csa</i> expression and the placental binding phenotype in <i>Plasmodium falciparum</i>
Epigenetics and chromatin structure regulate <i>var2csa</i> expression and the placental binding phenotype in <i>Plasmodium falciparum</i> Open
Plasmodium falciparum is responsible for what appears to be a never-ending public health issue in the developing world. With repeated infections, a gradual semi-immunity to severe malaria can be acquired but this is disrupted when women be…
View article: DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages
DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages Open
Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. Here we have characterized an e…
View article: <i>Pf</i> MORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, <i>Plasmodium falciparum</i>
<i>Pf</i> MORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, <i>Plasmodium falciparum</i> Open
The environmental challenges the human malaria parasite, Plasmodium falciparum , faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regul…
View article: Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum
Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum Open
The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. Increasing evidence now suggests a major role for epigenetic mechanisms in gene …
View article: PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages
PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages Open
Malaria pathogenicity results from the parasite’s ability to invade, multiply within and then egress from the host red blood cell (RBC). Infected RBCs are remodeled, expressing antigenic variant proteins (such as PfEMP1, coded by the var g…
View article: Babesia duncani multi-omics identifies virulence factors and drug targets
Babesia duncani multi-omics identifies virulence factors and drug targets Open
Babesiosis is a malaria-like disease in humans and animals that is caused by Babesia species, which are tick-transmitted apicomplexan pathogens. Babesia duncani causes severe to lethal infection in humans, but despite the risk that this pa…
View article: Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite
Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite Open
The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. However, this cascade of transcripts is unlikely to be regulated by the limited …
View article: Decoding The Nuclear Genome of The Human Pathogen <i>Babesia duncani</i> Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa
Decoding The Nuclear Genome of The Human Pathogen <i>Babesia duncani</i> Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa Open
Babesia species are tick-transmitted apicomplexan pathogens and the causative agents of babesiosis, a malaria-like disease of major medical and veterinary importance. Of the different species of Babesia reported so far, Babesia duncani cau…
View article: Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity? Open
The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the phys…
View article: Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites
Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites Open
Mounting evidence supports the idea that epigenetic, and the overall 3-dimensional (3D) architecture of the genome, plays an important role in gene expression for eukaryotic organisms. We recently used Hi-C methodologies to generate and co…