Todd R. Sponholtz
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View article: Validation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database
Validation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database Open
The composite algorithm was demonstrated to be a sensitive and precise measure of mortality, while individual database sources were accurate but had limited sensitivity.
View article: Adapting the European Concerted Action on Congenital Anomalies and Twins (<scp>EUROCAT</scp>) Guide 1.5 for Use in Post‐Authorisation Safety Studies Using US Data
Adapting the European Concerted Action on Congenital Anomalies and Twins (<span>EUROCAT</span>) Guide 1.5 for Use in Post‐Authorisation Safety Studies Using US Data Open
Purpose Many post‐authorization safety studies focus on congenital malformations and rely on diagnosis codes found in US data sources. However, no authoritative standards exist for identifying and classifying malformations in these data. T…
View article: Evaluation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database
Evaluation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database Open
Purpose Ascertainment of mortality is critical to epidemiologic studies. Secondary collected database studies face challenges given the need to record mortality data in health claims or electronic medical records. The National Death Index …
View article: Strategy for identifying insulin pump use in Clinical Practice Research Datalink GOLD
Strategy for identifying insulin pump use in Clinical Practice Research Datalink GOLD Open
Background Clinical Practice Research Datalink (CPRD) GOLD is an invaluable resource for clinical research. However, some exposures are difficult to capture, including continuous subcutaneous insulin infusion pump systems (“insulin pumps”)…
View article: Risk factors for endometrial cancer in Black women
Risk factors for endometrial cancer in Black women Open
View article: Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum
Quality and Completeness of Myocardial Infarction Recording in Clinical Practice Research Datalink Aurum Open
MI diagnoses recorded in CPRD Aurum were highly likely to be correct, supporting its use in clinical research studies. Completeness was lower, indicating the need for data linkage for some studies.
View article: Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium
Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium Open
A full‐term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations between other pregnancy‐related factors an…
View article: Night Shift Work and Fecundability in Late Reproductive-Aged African American Women
Night Shift Work and Fecundability in Late Reproductive-Aged African American Women Open
Background: We estimated the association between night shift work and fecundability among African American women. Methods: Black Women's Health Study participants (n = 560) aged 30-45 years reported their…
View article: Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk
Association of Variability in Body Mass Index and Metabolic Health With Cardiometabolic Disease Risk Open
Background Metabolic syndrome is associated with high risk of cardiovascular disease, although risk may differ according to the specific conditions present and variability in those conditions. Methods and Results We defined obesity (body m…
View article: Natural History of Obesity Subphenotypes: Dynamic Changes Over Two Decades and Prognosis in the Framingham Heart Study
Natural History of Obesity Subphenotypes: Dynamic Changes Over Two Decades and Prognosis in the Framingham Heart Study Open
Context The natural histories of obesity subphenotypes are incompletely delineated. Objectives To investigate dynamic changes in obesity subphenotypes and associations with outcomes. Design, Setting, Participants, and Measurements Framingh…
View article: Contribution of the neighborhood environment to cross-sectional variation in long-term CVD risk scores in the Framingham Heart Study
Contribution of the neighborhood environment to cross-sectional variation in long-term CVD risk scores in the Framingham Heart Study Open
Few studies of the health impact of the built environment have examined downstream outcomes, such as cardiovascular disease. We analyzed the neighborhood-level proportional variance in the 10- and 30-year Framingham risk scores (FRS) in th…
View article: Exogenous Hormone Use and Endometrial Cancer in U.S. Black Women
Exogenous Hormone Use and Endometrial Cancer in U.S. Black Women Open
Background: Although endometrial cancer risk differs among white and black women, few data on its associations with exogenous hormone use in the latter group are available. Studies have reported lower endometrial cancer risk among users of…
View article: Breastfeeding and Endometrial Cancer Risk
Breastfeeding and Endometrial Cancer Risk Open
OBJECTIVE: To investigate the association between breastfeeding and endometrial cancer risk using pooled data from 17 studies participating in the Epidemiology of Endometrial Cancer Consortium. METHODS: We conducted a meta-analysis with in…
View article: History of uterine leiomyoma and risk of endometrial cancer in black women
History of uterine leiomyoma and risk of endometrial cancer in black women Open
View article: Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women
Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women Open
Total and abdominal obesity, as well as metabolic factors such as type 2 diabetes, have been associated with a higher risk of endometrial cancer in white women. It remains unclear to what extent these factors influence the risk of endometr…
View article: Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study
Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study Open
Dietary long-chain (LC) ω-3 polyunsaturated fatty acids (PUFAs), which derive primarily from intakes of fatty fish, are thought to inhibit inflammation and de novo estrogen synthesis. This study prospectively examined the associations of d…
View article: Occupational exposures and chronic kidney disease: Possible associations with endotoxin and ultrafine particles
Occupational exposures and chronic kidney disease: Possible associations with endotoxin and ultrafine particles Open
Background Chronic kidney disease (CKD) carries a high public health burden yet there is limited research on occupational factors, which are examined in this retrospective case‐control study. Methods Newly diagnosed cases of CKD (n = 547) …