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View article: <scp>RNF213</scp>‐Dependent <scp>EGFR</scp> and <scp>HER2</scp> Activation Regulates Specific Downstream Signaling Pathways in Human Cancer Cells
<span>RNF213</span>‐Dependent <span>EGFR</span> and <span>HER2</span> Activation Regulates Specific Downstream Signaling Pathways in Human Cancer Cells Open
In this study, we reveal a novel relationship between RNF213, an E3 ubiquitin ligase associated with Moyamoya disease (MMD) and the ubiquitination of both endogenous and pathogenic substrates, and EGFR, the epithelial growth factor recepto…
View article: RNF213 Acts as a Molecular Switch for Cav-1 Ubiquitination and Phosphorylation in Human Cells
RNF213 Acts as a Molecular Switch for Cav-1 Ubiquitination and Phosphorylation in Human Cells Open
RNF213 encodes a unique protein with AAA+ ATPase and E3 ubiquitin ligase activities that are critical for its diverse roles, which range from involvement in human vasculopathies, such as Moyamoya disease, to ubiquitination of viral and bac…
View article: Development of a Vascular Organoid Model for Moyamoya Disease Using Patient-Derived iPS Cells
Development of a Vascular Organoid Model for Moyamoya Disease Using Patient-Derived iPS Cells Open
View article: α-Parvin Expression in Breast Cancer Tissues: Correlation with Clinical Parameters and Prognostic Significance
α-Parvin Expression in Breast Cancer Tissues: Correlation with Clinical Parameters and Prognostic Significance Open
Stromal cells play a critical role in the tumor microenvironment of breast cancer (BC), as they are recruited by tumor cells and regulate the metastatic spread. Though high expression of α-parvin, a member of the parvin family of actin-bin…
View article: Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria
Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria Open
Familial episodic pain syndrome (FEPS) is an early childhood onset disorder of severe episodic limb pain caused mainly by pathogenic variants of SCN11A, SCN10A, and SCN9A, which encode three voltage-gated sodium channels (VGSCs) expressed …
View article: Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice
Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice Open
The neuromuscular junction (NMJ) forms centrally in myotubes and, as the only synapse between motor neuron and myotube, are indispensable for motor activity. The midmuscle formation of NMJs, including midmuscle-restricted expression of NMJ…
View article: A case of gastric cancer associated with gastrointestinal stromal tumor revealed incidentally after gastrectomy
A case of gastric cancer associated with gastrointestinal stromal tumor revealed incidentally after gastrectomy Open
The patient was a man in his 70s. During hospitalization for glycemic control for diabetes mellitus, an upper gastrointestinal endoscopy was performed. Endoscopic ultrasound revealed infiltration into the proper muscle layer, and laparosco…
View article: The effect of underweight on mid-term outcome following transcatheter aortic valve implantation: an insight from multicenter registry
The effect of underweight on mid-term outcome following transcatheter aortic valve implantation: an insight from multicenter registry Open
Background Obesity has the adverse prognostic impact in the general population, whereas paradoxical effect of obesity has been reported in patients with heart failure. Several studies have suggested the same obesity paradox in patients und…
View article: Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner
Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner Open
View article: Supplementary Material for: Lysophosphatidic Acid Regulates the Differentiation of Th2 Cells and Its Antagonist Suppresses Allergic Airway Inflammation
Supplementary Material for: Lysophosphatidic Acid Regulates the Differentiation of Th2 Cells and Its Antagonist Suppresses Allergic Airway Inflammation Open
Background: Lysophosphatidic acid (LPA), a prototypic member of a large family of lysophospholipids, has been recently shown to play a role in immune responses to respiratory diseases. The involvement of LPA in allergic airwa…
View article: <i> <scp>DOK</scp> 7 </i> gene therapy enhances motor activity and life span in <scp>ALS</scp> model mice
<i> <span>DOK</span> 7 </i> gene therapy enhances motor activity and life span in <span>ALS</span> model mice Open
Amyotrophic lateral sclerosis ( ALS ) is a progressive, multifactorial motor neurodegenerative disease with severe muscle atrophy. The glutamate release inhibitor riluzole is the only medication approved by the FDA , and prolongs patient l…
View article: Effect of femoral canal shape on mechanical stress distribution and adaptive bone remodelling around a cementless tapered-wedge stem
Effect of femoral canal shape on mechanical stress distribution and adaptive bone remodelling around a cementless tapered-wedge stem Open
Objectives In total hip arthroplasty (THA), the cementless, tapered-wedge stem design contributes to achieving initial stability and providing optimal load transfer in the proximal femur. However, loading conditions on the femur following …
View article: Postnatal knockdown of <i>dok‐7</i> gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology
Postnatal knockdown of <i>dok‐7</i> gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology Open
The neuromuscular junction (NMJ) is a synapse between a motor neuron and skeletal muscle and is required for muscle contraction. The formation and maintenance of NMJs are governed by the muscle‐specific receptor tyrosine kinase MuSK. We pr…