Toine C. G. Egberts
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View article: Patient preferences and attitudes regarding the environmental impact of medicines: A discrete choice experiment
Patient preferences and attitudes regarding the environmental impact of medicines: A discrete choice experiment Open
Aims Pharmaceutical utilization within global healthcare has significant environmental impact throughout its lifecycle. Understanding how the environmental impact of medicines influences patients' preferences relative to ease of use and co…
View article: Obituary Ronald Meyboom: A Professional Life Devoted to Pharmacovigilance
Obituary Ronald Meyboom: A Professional Life Devoted to Pharmacovigilance Open
View article: Quality of Clinical Information in Pregnancy Pharmacovigilance Data Sources—A Contribution of the ConcePTION Project
Quality of Clinical Information in Pregnancy Pharmacovigilance Data Sources—A Contribution of the ConcePTION Project Open
Purpose Good documentation of adverse events related to medicines is essential for the assessment of safety signals. Information on the clinical quality of primary pregnancy safety data sources is lacking. The objective of this study was t…
View article: Patient Preferences and Attitudes Regarding the Environmental Impact of Medicines: A Discrete Choice Experiment
Patient Preferences and Attitudes Regarding the Environmental Impact of Medicines: A Discrete Choice Experiment Open
View article: The association between interleukin-6 inhibitors as treatment for COVID-19 and mental health problems in ICU survivors
The association between interleukin-6 inhibitors as treatment for COVID-19 and mental health problems in ICU survivors Open
Objective: To assess whether exposure to interleukin-6 (IL-6) inhibitors as treatment for critically ill COVID-19 patients is associated with a lower prevalence of mental health problems one year after ICU admission. Design: Retrospective …
View article: The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists
The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists Open
Background Low-dose (0.5 mg/day) colchicine improves cardiovascular outcomes in patients with stable coronary disease. Around 10–15% of these patients simultaneously use anticoagulant therapy, including vitamin-K antagonists (VKAs). In vit…
View article: Definitions, measurement, and reporting of progression-free survival in randomized clinical trials and observational studies of patients with advanced non-small-cell lung cancer treated with immunotherapy: a scoping review
Definitions, measurement, and reporting of progression-free survival in randomized clinical trials and observational studies of patients with advanced non-small-cell lung cancer treated with immunotherapy: a scoping review Open
Background: Evidence from observational studies is increasingly used in oncology to complement evidence from clinical trials. Commonly used endpoints to evaluate oncology medicines are overall survival (OS) and progression-free survival (P…
View article: The feasibility of using real world data as external control arms in oncology trials
The feasibility of using real world data as external control arms in oncology trials Open
Before real world data (RWD)-derived external control arms (ECAs) can be applied in clinical trials within the field of oncology, it must be determined whether these ECAs can function as appropriate and reliable control arms. This review p…
View article: Physical compatibility of insulin aspart, lidocaine, alprostadil and vancomycin with individualised two-in-one parenteral nutrition used in the neonatal intensive care unit
Physical compatibility of insulin aspart, lidocaine, alprostadil and vancomycin with individualised two-in-one parenteral nutrition used in the neonatal intensive care unit Open
Alprostadil and vancomycin IV solutions are physically compatible with two individualised neonatal PN solutions, with high as well as low glucose concentrations. Combinations of PN with lidocaine or insulin form subvisible particles, which…
View article: Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival
Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival Open
This study revealed that patients with impaired liver function treated with paclitaxel for breast and ovarian cancer in an advanced setting are at greater risk of developing hematological toxicity than patients with normal liver function a…
View article: Uncertainties about the benefit-risk balance of oncology medicines assessed by the European Medicines Agency
Uncertainties about the benefit-risk balance of oncology medicines assessed by the European Medicines Agency Open
At the time of initial marketing authorisation of oncology medicines, uncertainties about their benefit-risk balance most often concerned safety aspects, followed by efficacy. The number of uncertainties was highest for cell and gene thera…
View article: Correction: The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy
Correction: The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy Open
View article: Environmental Outcomes of Reducing Medication Waste by Redispensing Unused Oral Anticancer Drugs
Environmental Outcomes of Reducing Medication Waste by Redispensing Unused Oral Anticancer Drugs Open
Importance Medications are associated with substantial environmental outcomes, yet frequently end up being unused by patients. Waste-minimizing interventions, such as redispensing of quality-approved oral anticancer drugs remaining unused …
View article: Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity
Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity Open
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment strategy for patients with inborn errors of immunities (IEIs). The objective of this study was to assess the optimal busulfan exposure before allogenei…
View article: The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy
The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy Open
View article: Barriers and facilitators to implement the redispensing of unused oral anticancer drugs in clinical care: A hybrid-effectiveness type I study
Barriers and facilitators to implement the redispensing of unused oral anticancer drugs in clinical care: A hybrid-effectiveness type I study Open
View article: Leftover of Amoxicillin Suspension After Use by Children in the Netherlands
Leftover of Amoxicillin Suspension After Use by Children in the Netherlands Open
Purpose In clinical practice, a discrepancy may exist between the prescribed amount of a drug and the commercially available pack sizes in the pharmacy, potentially contributing to drug waste. This study aimed—as an example of this phenome…
View article: Busulfan Exposure Target Attainment in Adults Undergoing Allogeneic Hematopoietic Cell Transplantation: A Single Day Versus a Multiple Day Therapeutic Drug Monitoring Regimen
Busulfan Exposure Target Attainment in Adults Undergoing Allogeneic Hematopoietic Cell Transplantation: A Single Day Versus a Multiple Day Therapeutic Drug Monitoring Regimen Open
Busulfan exposure has previously been linked to clinical outcomes, hence the need for therapeutic drug monitoring (TDM). Study objective was to evaluate the effect of day 1 TDM-guided dosing (regimen d1) versus days 1 + 2 TDM-guided dosing…
View article: Development of a text mining algorithm for identifying adverse drug reactions in electronic health records
Development of a text mining algorithm for identifying adverse drug reactions in electronic health records Open
Objective Adverse drug reactions (ADRs) are a significant healthcare concern. They are often documented as free text in electronic health records (EHRs), making them challenging to use in clinical decision support systems (CDSS). The study…
View article: Assessing accuracy of ChatGPT in response to questions from day to day pharmaceutical care in hospitals
Assessing accuracy of ChatGPT in response to questions from day to day pharmaceutical care in hospitals Open
While concordance of responses was excellent, the accuracy and reproducibility were poor. With the described method, ChatGPT should not be used to address questions encountered by hospital pharmacists during their shifts. However, it is im…
View article: Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival
Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival Open
Background: The anticancer drug paclitaxel is primarily metabolised in the liver. Previous studies indicated a correlation between impaired liver function and paclitaxel toxicity which may indicate dose reduction. Since evidence is limited…
View article: Intranasal vitamin B<sub>12</sub> administration in elderly patients: A randomized controlled comparison of two dosage regimens
Intranasal vitamin B<sub>12</sub> administration in elderly patients: A randomized controlled comparison of two dosage regimens Open
Aim Vitamin B 12 deficiency is common in the elderly population. Standard treatment via intramuscular injections, however, has several disadvantages. Safer and more convenient dosage forms such as intranasal are therefore being explored. T…
View article: Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration
Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration Open
Administering tacrolimus orally directly after LuTx leads to a higher variability in blood concentrations compared to intravenous administration. There was no difference in the occurrence of AKI or transplant rejection.
View article: 3PC-004 Drug waste of ready-to-administer syringes in the intensive care unit: aseptically prepared syringes versus prefilled sterilised syringes
3PC-004 Drug waste of ready-to-administer syringes in the intensive care unit: aseptically prepared syringes versus prefilled sterilised syringes Open
Background and Importance The availability of ready-to-administer (RTA) syringes for intravenous drugs facilitates rapid and safe administration in emergency and intensive care situations. However, the preparation of these syringes in hosp…
View article: Hospital physicians’ and older patients’ agreement with individualised STOPP/START based medication optimisation recommendations in a clinical trial setting
Hospital physicians’ and older patients’ agreement with individualised STOPP/START based medication optimisation recommendations in a clinical trial setting Open
OBJECTIVE: To evaluate agreement of hospital physicians and older patients with individualised STOPP/START based medication optimisation recommendations from a pharmacotherapy team. METHODS: This study was embedded within a large European,…
View article: Validation of a Novel Method to Assess the Clinical Quality of Information in Pregnancy-Related Pharmacovigilance Case Reports: A ConcePTION Project
Validation of a Novel Method to Assess the Clinical Quality of Information in Pregnancy-Related Pharmacovigilance Case Reports: A ConcePTION Project Open
View article: Pembrolizumab Plus Chemotherapy Per PD-L1 Stratum In Patients With Metastatic Non–Small Cell Lung Cancer: Real-World Effectiveness Versus Trial Efficacy
Pembrolizumab Plus Chemotherapy Per PD-L1 Stratum In Patients With Metastatic Non–Small Cell Lung Cancer: Real-World Effectiveness Versus Trial Efficacy Open
No significant EE gap was found for pembrolizumab plus chemotherapy, except in the stratum nonsquamous mNSCLC with <1% PD-L1 tumor expression. In these patients, the survival in real-world was considerably shorter compared to the clinical …
View article: Cost Savings and Waste Reduction Through Redispensing Unused Oral Anticancer Drugs
Cost Savings and Waste Reduction Through Redispensing Unused Oral Anticancer Drugs Open
Importance New strategies targeting waste are required to improve financial and ecologic sustainability of expensive therapies, such as oral anticancer drugs, that frequently remain unused by patients. Redispensing unused oral anticancer d…
View article: The Nature, Causes, and Clinical Impact of Errors in the Clinical Laboratory Testing Process Leading to Diagnostic Error: A Voluntary Incident Report Analysis
The Nature, Causes, and Clinical Impact of Errors in the Clinical Laboratory Testing Process Leading to Diagnostic Error: A Voluntary Incident Report Analysis Open
Objectives Diagnostic errors, that is, missed, delayed, or wrong diagnoses, are a common type of medical errors and preventable iatrogenic harm. Errors in the laboratory testing process can lead to diagnostic errors. This retrospective ana…
View article: Drug waste of ready-to-administer syringes in the intensive care unit: Aseptically prepared syringes versus prefilled sterilized syringes
Drug waste of ready-to-administer syringes in the intensive care unit: Aseptically prepared syringes versus prefilled sterilized syringes Open
Drug waste of RTA syringes for the ICU can be significantly decreased by introducing PFSSs, supporting hospitals to enhance environmental sustainability. Furthermore, the waste percentage of RTA syringes prepared through aseptic batchwise …