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View article: Figure S4 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S4 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Staining for proliferation and apoptosis before and after MYC deactivation.
View article: Supplementary Tables from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Supplementary Tables from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
LC-MS/MS method details for eicosanoid analysis (Tables S1 and S2); Lipid ID by accurate mass and tandem MS (Tables S3 and S4); Fold change for eicosanoid-related species with MYC activated (Table S5).
View article: Figure S2 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S2 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Relative abundances of free fatty acids, phosphatidylglycerols and phosphatidylinositols in tumour compared to normal lung tissue.
View article: Figure S6 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S6 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Multivariate statistics for eicosanoid profiles.
View article: Figure S3 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S3 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Liquid extraction surface analysis mass spectrometry differentiates normal from tumour tissue.
View article: Figure S1 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S1 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Clustering of MALDI imaging dataset for a lung section.
View article: Figure S3 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S3 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Liquid extraction surface analysis mass spectrometry differentiates normal from tumour tissue.
View article: Data from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Data from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
MYC-mediated pathogenesis in lung cancer continues to attract interest for new therapeutic strategies. In this study, we describe a transgenic mouse model of KRAS-driven lung adenocarcinoma that affords reversible activation of MYC, used h…
View article: Supplemental Figure Legends from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Supplemental Figure Legends from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Figure legends for supplemental Figures S1-S6.
View article: Figure S6 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S6 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Multivariate statistics for eicosanoid profiles.
View article: Figure S5 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S5 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Example chromatograms for eicosanoid analysis by LC-MS/MS.
View article: Figure S5 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S5 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Example chromatograms for eicosanoid analysis by LC-MS/MS.
View article: Figure S2 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S2 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Relative abundances of free fatty acids, phosphatidylglycerols and phosphatidylinositols in tumour compared to normal lung tissue.
View article: Figure S4 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S4 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Staining for proliferation and apoptosis before and after MYC deactivation.
View article: Supplementary Tables from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Supplementary Tables from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
LC-MS/MS method details for eicosanoid analysis (Tables S1 and S2); Lipid ID by accurate mass and tandem MS (Tables S3 and S4); Fold change for eicosanoid-related species with MYC activated (Table S5).
View article: Data from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Data from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
MYC-mediated pathogenesis in lung cancer continues to attract interest for new therapeutic strategies. In this study, we describe a transgenic mouse model of KRAS-driven lung adenocarcinoma that affords reversible activation of MYC, used h…
View article: Figure S1 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Figure S1 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Clustering of MALDI imaging dataset for a lung section.
View article: Supplemental Figure Legends from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Supplemental Figure Legends from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
Figure legends for supplemental Figures S1-S6.
View article: Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73. Open
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By…
View article: Therapeutically expanded human regulatory T-cells are super- suppressive due to HIF1A induced expression of CD73.
Therapeutically expanded human regulatory T-cells are super- suppressive due to HIF1A induced expression of CD73. Open
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By…
View article: A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans
A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans Open
BACKGROUNDDietary changes have led to the growing prevalence of type 2 diabetes and nonalcoholic fatty liver disease. A hallmark of both disorders is hepatic lipid accumulation, derived in part from increased de novo lipogenesis. Despite t…
View article: Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release
Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release Open
Exercise is an effective intervention for the prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals that contribute to the beneficial effects of exercise on cardiometabolic health. Inorganic nitrate increas…
View article: Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (i.e., nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Currently, the driver for this progression is not fully unde…
View article: Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer Open
MYC-mediated pathogenesis in lung cancer continues to attract interest for new therapeutic strategies. In this study, we describe a transgenic mouse model of KRAS-driven lung adenocarcinoma that affords reversible activation of MYC, used h…
View article: 180 Early Life Exposure to Maternal Obesity Perturbs Renal Morphology in Mice
180 Early Life Exposure to Maternal Obesity Perturbs Renal Morphology in Mice Open
Introduction The incidence of Chronic Kidney Disease (CKD) has risen globally by 83% since 1990, concurrently with type 2 diabetes and metabolic syndrome. Studies of maternal under-nutrition during pregnancy have highlighted that the kidne…