Tom Boonen
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View article: FORCETRACKER: A versatile tool for standardized assessment of tissue contractile properties in 3D Heart-on-Chip platforms
FORCETRACKER: A versatile tool for standardized assessment of tissue contractile properties in 3D Heart-on-Chip platforms Open
Engineered heart tissues (EHTs) have shown great potential in recapitulating tissue organization, functions, and cell-cell interactions of the human heart in vitro . Currently, multiple EHT platforms are used by both industry and academia …
View article: Micro‐Engineered Heart Tissues On‐Chip with Heterotypic Cell Composition Display Self‐Organization and Improved Cardiac Function
Micro‐Engineered Heart Tissues On‐Chip with Heterotypic Cell Composition Display Self‐Organization and Improved Cardiac Function Open
Advanced in vitro models that recapitulate the structural organization and function of the human heart are highly needed for accurate disease modeling, more predictable drug screening, and safety pharmacology. Conventional 3D Engineered He…
View article: Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking
Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking Open
The high rate of drug withdrawal from the market due to cardiovascular toxicity or lack of efficacy, the economic burden, and extremely long time before a compound reaches the market, have increased the relevance of human in vitro models l…
View article: Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application
Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application Open
The use of Engineered Heart Tissues (EHT) as in vitro model for disease modeling and drug screening has increased, as they provide important insight into the genetic mechanisms, cardiac toxicity or drug responses. Consequently, this has hi…