Tom Burke
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View article: Patient-Reported Outcomes Following UGN-102 Treatment in Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer: An Analysis of 3 Clinical Trials
Patient-Reported Outcomes Following UGN-102 Treatment in Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer: An Analysis of 3 Clinical Trials Open
In these analyses, patients with LG-IR-NMIBC receiving UGN-102 did not report worsening QoL, functioning, or symptom burden, supporting its use as a nonsurgical treatment for LG-IR-NMIBC.
View article: Moderated Online Social Therapy (MOST) in Help-Seeking Young People: Pilot Randomized Controlled Study
Moderated Online Social Therapy (MOST) in Help-Seeking Young People: Pilot Randomized Controlled Study Open
Background In the context of a sharp rise in help-seeking in youth mental health, digital mental health interventions offer enormous potential to improve outcomes, facilitate access, and meet the increasing demand for mental health service…
View article: Moderated Online Social Therapy (MOST) In Help-Seeking Young People: A Pilot Randomised Controlled Study. (Preprint)
Moderated Online Social Therapy (MOST) In Help-Seeking Young People: A Pilot Randomised Controlled Study. (Preprint) Open
BACKGROUND In the context of a sharp rise in help-seeking in youth mental health, digital mental health interventions offer enormous potential to improve outcomes, facilitate access, and meet the increasing demand on mental health service…
View article: A Network Analysis of the Associations Between the Dark Triad Traits and Domains of Emotional Functioning
A Network Analysis of the Associations Between the Dark Triad Traits and Domains of Emotional Functioning Open
The aim of this study was to reexamine relationships between the Dark Triad traits and aspects of emotional functioning, such as emotional intelligence and empathy, as traits and abilities, by using a network analysis approach. The sample …
View article: Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Levels
Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Levels Open
Our results indicate that higher plasma IL-6 levels may be differently associated with the severity of depressive and negative symptoms dependent on the illness stage. Future work identifying elevated levels of inflammation in larger sampl…
View article: Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias
Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias Open
Introduction Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterised by functional and structural brain dysconnectivity and disturbances in perception, cognition, emotion, and social functioning. In the present study, we…
View article: Disseminating the research findings from the adolescents and adults living with Perinatal HIV (AALPHI) study: an approach from young people living with HIV
Disseminating the research findings from the adolescents and adults living with Perinatal HIV (AALPHI) study: an approach from young people living with HIV Open
Background The Adolescents and Adults Living with Perinatal HIV (AALPHI) study is one of only three cohort studies worldwide evaluating the impact of HIV on young people living with perinatal HIV (PLHIV) relative to a comparable group of H…
View article: A 20-Year Systematic Review of the ‘Reading the Mind in the Eyes’ Test across Neurodegenerative Conditions
A 20-Year Systematic Review of the ‘Reading the Mind in the Eyes’ Test across Neurodegenerative Conditions Open
Social cognition has a broad theoretical definition, which includes the ability to mentalise, i.e., recognise and infer mental states to explain and predict another’s behaviour. There is growing recognition of the clinical, diagnostic, and…
View article: Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia
Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia Open
Childhood trauma (CT) is associated with lower cognitive and social cognitive function in schizophrenia. Recent evidence suggests that the relationship between CT and cognition is mediated by both low-grade systemic inflammation and reduce…
View article: Evidence supporting the use of a brief cognitive assessment in routine clinical assessment for psychosis
Evidence supporting the use of a brief cognitive assessment in routine clinical assessment for psychosis Open
Cognitive impairment is a core feature of psychosis. Full cognitive assessments are not often conducted in routine clinical practice as administration is time-consuming. Here, we investigated whether brief tests of cognition could be used …
View article: Emotion Recognition and the Screening Instrument for Borderline Personality Disorder (SI-Bord): Outcomes and Community-Based Validation
Emotion Recognition and the Screening Instrument for Borderline Personality Disorder (SI-Bord): Outcomes and Community-Based Validation Open
Background: Borderline Personality Disorder (BPD) is a psychiatric condition characterized by impulsivity, affect instability, dysregulation, low self-image, and interpersonal difficulties. There are many instruments to measure traits of B…
View article: Borderline personality disorder traits and mentalising ability: The self-other social cognition paradox
Borderline personality disorder traits and mentalising ability: The self-other social cognition paradox Open
Objective Borderline personality disorder (BPD) is a psychiatric condition characterised by a pervasive pattern of impulsivity, low self-image, and interpersonal conflicts. Previous findings indicate a mixed relationship between BPD and so…
View article: Corpus Callosum Microstructural Tract Integrity Relates to Longer Emotion Recognition Reaction Time in People with Schizophrenia
Corpus Callosum Microstructural Tract Integrity Relates to Longer Emotion Recognition Reaction Time in People with Schizophrenia Open
Objective: Schizophrenia is a complex functionally debilitating neurodevelopmental disorder, with associated social cognitive impairment. Corpus Callosum (CC) white matter tracts deficits are reported for people with schizophrenia; however…
View article: Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis
Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis Open
Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diff…
View article: Emotion Recognition and the Screening Instrument for Borderline Personality Disorder (SI-Bord): outcomes and community-based validation
Emotion Recognition and the Screening Instrument for Borderline Personality Disorder (SI-Bord): outcomes and community-based validation Open
Background Borderline Personality Disorder (BPD) is a psychiatric condition characterized by impulsivity, affect instability, dysregulation, low self-image, and interpersonal difficulties. There are many instruments to measure traits of BP…
View article: BioImage Model Zoo: A Community-Driven Resource for Accessible Deep Learning in BioImage Analysis
BioImage Model Zoo: A Community-Driven Resource for Accessible Deep Learning in BioImage Analysis Open
Deep learning-based approaches are revolutionizing imaging-driven scientific research. However, the accessibility and reproducibility of deep learning-based workflows for imaging scientists remain far from sufficient. Several tools have re…
View article: Quality of Life Outcomes in a Community Cohort of Adults With an Intellectual Disability Using the Personal Outcome Scale
Quality of Life Outcomes in a Community Cohort of Adults With an Intellectual Disability Using the Personal Outcome Scale Open
Objectives Quality of life (QoL) is a multi-dimensional phenomenon composed of core domains that are influenced by personal characteristics, values, and environmental contributions. There are eight core domains of QoL aligned with both the…
View article: Psychological Flexibility Mediates Wellbeing for People with Adverse Childhood Experiences during COVID-19
Psychological Flexibility Mediates Wellbeing for People with Adverse Childhood Experiences during COVID-19 Open
Background: The psychological impact of COVID-19 is multifaceted, both acute and chronic, and has not affected everyone equally. Method: This longitudinal study compared those with and without Adverse Childhood Experiences (ACEs) on measur…
View article: The impact of the first wave of the Covid‐19 pandemic on parents of children with externalising difficulties in ireland: A longitudinal cohort study
The impact of the first wave of the Covid‐19 pandemic on parents of children with externalising difficulties in ireland: A longitudinal cohort study Open
Results provide important information regarding the trajectory of psychological outcomes in parents of children with externalising difficulties over the first wave of the COVID-19 pandemic, highlighting the need for increased parental supp…
View article: Coping with global uncertainty: Perceptions of COVID-19 psychological distress, relationship quality, and dyadic coping for romantic partners across 27 countries
Coping with global uncertainty: Perceptions of COVID-19 psychological distress, relationship quality, and dyadic coping for romantic partners across 27 countries Open
Following the global outbreak of COVID-19 in March 2020, individuals report psychological distress associated with the “new normal”—social distancing, financial hardships, and increased responsibilities while working from home. Given the i…
View article: A remote self-directed psychological intervention for the public: The PAUSE programme protocol
A remote self-directed psychological intervention for the public: The PAUSE programme protocol Open
Background: This protocol outlines procedures for the development and evaluation of a remotely accessible intervention tool known as the ‘Psychology And yoU: Self-Enhancement programme’ (i.e., PAUSE programme). The PAUSE programme aims to …
View article: A Road Map for Remote Digital Health Technology for Motor Neuron Disease
A Road Map for Remote Digital Health Technology for Motor Neuron Disease Open
Despite recent and potent technological advances, the real-world implementation of remote digital health technology in the care and monitoring of patients with motor neuron disease has not yet been realized. Digital health technology may i…
View article: Staff member's views and attitudes to supporting people with an Intellectual Disability: A multi‐method investigation of intimate relationships and sexuality
Staff member's views and attitudes to supporting people with an Intellectual Disability: A multi‐method investigation of intimate relationships and sexuality Open
Background Staff member's views and attitudes can have a significant impact on people with an intellectual disability. This study explores staff attitudes and experiences of people with an intellectual disability's expression of relationsh…