Tom C. Freeman
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View article: CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue Open
CD4+ TRM17 cells are the predominant source of IL-17A in SpA synovial tissue. TCR stimulation is essential for the secretion of IL-17A by CD4+TRM17-like cells. The epigenetic regulator bromodomain-containing protein 1 (BRD1) contributes to…
View article: Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling
Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling Open
IL-23 is implicated in the pathogenesis of immune-mediated inflammatory diseases, and myeloid cells that express Fc gamma receptor 1 (FcγRI or CD64) on their surface have been recently identified as a primary source of IL-23 in inflamed ti…
View article: Serum Collagen Biomarkers Are Reflective of Tissue Specific Fibroblasts Associated With Ulcerative Colitis Activity and Treatment Response to Ustekinumab
Serum Collagen Biomarkers Are Reflective of Tissue Specific Fibroblasts Associated With Ulcerative Colitis Activity and Treatment Response to Ustekinumab Open
Background There is a need to identify peripheral biomarkers reflective of defined disease associated fibroblasts in Ulcerative Colitis (UC), with the aim of enabling clinical development approaches for novel‐stromal‐targeted therapeutics …
View article: DOP069 Guselkumab maintenance therapy mediates further improvements in intestinal immune homeostasis and mucosal healing in patients with ulcerative colitis
DOP069 Guselkumab maintenance therapy mediates further improvements in intestinal immune homeostasis and mucosal healing in patients with ulcerative colitis Open
Background Guselkumab (GUS) is a dual-acting IL-23p19 subunit inhibitor that potently neutralises interleukin 23 (IL-23) and binds to CD64, a receptor on cells that produce IL-23.1 The QUASAR Phase 2b/3 studies have demonstrated efficacy a…
View article: P0061 Guselkumab induction therapy results in molecular resolution of inflammation in moderately to severely active Ulcerative Colitis: results from the Phase 3 QUASAR induction study
P0061 Guselkumab induction therapy results in molecular resolution of inflammation in moderately to severely active Ulcerative Colitis: results from the Phase 3 QUASAR induction study Open
Background Guselkumab (GUS) is a selective dual-acting IL-23p19 subunit inhibitor that potently neutralises interleukin 23 (IL-23) and binds to CD64, a receptor on cells that produce IL-23.1 GUS is now approved in the United States for tre…
View article: RhlR-mediated cooperation in cystic fibrosis-adapted isolates of <i>Pseudomonas aeruginosa</i>
RhlR-mediated cooperation in cystic fibrosis-adapted isolates of <i>Pseudomonas aeruginosa</i> Open
Pseudomonas aeruginosa uses quorum sensing (QS) to regulate the expression of dozens of genes, many of which encode shared products, called “public goods.” P. aeruginosa possesses two complete acyl-homoserine lactone (AHL) QS circuits: the…
View article: Mechanisms of <i>Staphylococcus aureus</i> survival of trimethoprim-sulfamethoxazole-induced thymineless death
Mechanisms of <i>Staphylococcus aureus</i> survival of trimethoprim-sulfamethoxazole-induced thymineless death Open
Trimethoprim-sulfamethoxazole (SXT) is commonly used to treat diverse Staphylococcus aureus infections, including those associated with cystic fibrosis (CF) pulmonary disease. Studies with Escherichia coli found that SXT impairs tetrahydro…
View article: CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue Open
Objectives Interleukin (IL)-17A is a key driver of Spondyloarthritis (SpA) joint pathology. We aimed to identify its cellular source in synovial tissue from patients with two forms of SpA namely Axial SpA (AxSpA) and Psoriatic arthritis (P…
View article: P006 Development of a Crohn's disease molecular activity score to identify region-specific chronically inflamed and non-inflamed processes
P006 Development of a Crohn's disease molecular activity score to identify region-specific chronically inflamed and non-inflamed processes Open
Background Crohn’s disease (CD) is characterized by significant heterogeneity in disease location and other clinical factors, making it challenging to define the underlying molecular mechanisms associated with disease. Here, we provide a d…
View article: OP23 Guselkumab induction restores intestinal immune homeostasis and promotes epithelial repair in moderately to severely active Ulcerative Colitis
OP23 Guselkumab induction restores intestinal immune homeostasis and promotes epithelial repair in moderately to severely active Ulcerative Colitis Open
Background Selective inhibition of interleukin-23 (IL-23) through antagonism of the IL-23p19 subunit has demonstrated clinical efficacy in inflammatory bowel disease, but the mechanism of action (MoA) has not been fully defined. Here we pr…
View article: DOP54 Guselkumab and golimumab combination induction therapy in Ulcerative Colitis results in early local tissue healing that is sustained through guselkumab maintenance therapy
DOP54 Guselkumab and golimumab combination induction therapy in Ulcerative Colitis results in early local tissue healing that is sustained through guselkumab maintenance therapy Open
Background Combination induction therapy with guselkumab (GUS), an interleukin (IL)-23p19 subunit antagonist, and golimumab (GOL), a tumor necrosis factor (TNFα) antagonist, induced higher rates of clinical remission, endoscopic, and histo…
View article: P165 Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling
P165 Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling Open
Background IL-23 is implicated in the pathogenesis of inflammatory bowel disease (IBD) and myeloid cells that express FcγRI (CD64) have been identified as the primary cellular source of IL-23 in inflamed IBD gut tissue. Guselkumab (GUS) an…
View article: Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder
Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder Open
Chronic kidney disease–mineral and bone disorder (CKD-MBD) presents with extra-skeletal calcification and renal osteodystrophy (ROD). The origins of ROD likely lie with elevated uremic toxins and/or an altered hormonal profile but the cell…
View article: Cellular heterogeneity of the developing worker honey bee (<i>Apis mellifera</i>) pupa: a single cell transcriptomics analysis
Cellular heterogeneity of the developing worker honey bee (<i>Apis mellifera</i>) pupa: a single cell transcriptomics analysis Open
It is estimated that animals pollinate 87.5% of flowering plants worldwide and that managed honey bees (Apis mellifera) account for 30–50% of this ecosystem service to agriculture. In addition to their important role as pollinators, honey …
View article: Figure S2 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Figure S2 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Supplementary Figure 2
View article: Figure S2 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Figure S2 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Supplementary Figure 2
View article: Figure S1 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Figure S1 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Supplementary Figure 1
View article: Supplementary Figure Legends from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Supplementary Figure Legends from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Supplementary Figure Legends
View article: Data from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Data from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
The immune composition of the tumor microenvironment regulates processes including angiogenesis, metastasis, and the response to drugs or immunotherapy. To facilitate the characterization of the immune component of tumors from transcriptom…
View article: Figure S1 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Figure S1 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Supplementary Figure 1
View article: Supplementary tables from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Supplementary tables from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Tables 1 to 5
View article: Figure S3 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Figure S3 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Supplementary Figure 3
View article: Figure S3 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Figure S3 from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
Supplementary Figure 3
View article: Data from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Data from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Open
The immune composition of the tumor microenvironment regulates processes including angiogenesis, metastasis, and the response to drugs or immunotherapy. To facilitate the characterization of the immune component of tumors from transcriptom…