Tom Defoirdt
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View article: Indole signaling in <i>Escherichia coli</i> : a target for antivirulence therapy?
Indole signaling in <i>Escherichia coli</i> : a target for antivirulence therapy? Open
Pathogenic Escherichia coli are a major cause of infections in both humans and animals, leading to conditions such as severe diarrheal diseases, urinary tract infections, enteritis, and septicemia. To combat bacterial infections, an…
View article: Antimicrobial Resistance in Malaysian Shrimp Aquaculture and Strategies to Reduce Its Occurrence
Antimicrobial Resistance in Malaysian Shrimp Aquaculture and Strategies to Reduce Its Occurrence Open
Shrimp is a commercially important species in several regions and is among the key global aquaculture commodities essential for food production and security. Similar to most shrimp‐producing countries, shrimp aquaculture in Malaysia suffer…
View article: Resistance to quorum sensing inhibition spreads more slowly during host infection than antibiotic resistance
Resistance to quorum sensing inhibition spreads more slowly during host infection than antibiotic resistance Open
Antibiotic resistance is a rising problem and new and sustainable strategies to combat bacterial (intestinal) infections are therefore urgently needed. One promising strategy under intense investigation is the inhibition of quorum sensing,…
View article: Author Correction: Deciphering the virulent Vibrio harveyi causing spoilage in muscle of aquatic crustacean Litopenaeus vannamei
Author Correction: Deciphering the virulent Vibrio harveyi causing spoilage in muscle of aquatic crustacean Litopenaeus vannamei Open
View article: MINIREVIEW ON SUSTAINABLE ANTIVIRULENCE STRATEGY FOR AQUACULTURE
MINIREVIEW ON SUSTAINABLE ANTIVIRULENCE STRATEGY FOR AQUACULTURE Open
The increasing occurrence of antibiotic-resistant bacteria is one of the major challenges currently faced by the aquaculture sector. Ineffective applications of antibiotics to treat bacterial diseases, leading to the need for alternative s…
View article: The Effect of Caco-2 Cells on Sporulation and Enterotoxin Expression by Foodborne Clostridium perfringens
The Effect of Caco-2 Cells on Sporulation and Enterotoxin Expression by Foodborne Clostridium perfringens Open
Clostridium perfringens enterotoxin (Cpe)-producing strains cause gastrointestinal infections in humans and account for the second-largest number of all foodborne outbreaks caused by bacterial toxins. The Cpe toxin is only produced during …
View article: The impact of indole and mucin on sporulation, biofilm formation, and enterotoxin production in foodborne <i>Clostridium perfringens</i>
The impact of indole and mucin on sporulation, biofilm formation, and enterotoxin production in foodborne <i>Clostridium perfringens</i> Open
Aims Indole and mucin are compounds found in the host environment as they are produced by the host or by the host-associated microbiota. This study investigated whether indole and mucin impact Clostridium perfringens growth and sporulation…
View article: Weak selection for resistance to quorum sensing inhibition during multiple host infection cycles
Weak selection for resistance to quorum sensing inhibition during multiple host infection cycles Open
Quorum sensing (QS) inhibition is a promising novel approach to control bacterial infections. However, it is not clear whether QS inhibition will impose selective pressure for the spread of resistance against QS inhibition in pathogen popu…
View article: Bacterial and microalgal communities in carp polyculture systems: Composition, affecting factors and further perspectives
Bacterial and microalgal communities in carp polyculture systems: Composition, affecting factors and further perspectives Open
View article: Indole signaling, a promising target to control vibriosis in aquaculture
Indole signaling, a promising target to control vibriosis in aquaculture Open
View article: Bacterial and microalgal communities in carp polyculture systems: Composition, affecting factors and further perspectives.
Bacterial and microalgal communities in carp polyculture systems: Composition, affecting factors and further perspectives. Open
Carp polyculture is the planet's most widely practiced fish production system, using multiple fish species living in diverse trophic and spatial niches of a pond to maximize productivity. Increases in farm productivity can be supported by …
View article: Quorum‐sensing interference in vibrios
Quorum‐sensing interference in vibrios Open
Vibrios belonging to the Harveyi clade and the Splendidus clade are important pathogens that cause high economic losses in aquaculture. To control bacterial diseases, antibiotics have been widely applied in aquaculture worldwide for many y…
View article: Indole‐3‐acetic acid increases the survival of brine shrimp challenged with vibrios belonging to the Harveyi clade
Indole‐3‐acetic acid increases the survival of brine shrimp challenged with vibrios belonging to the Harveyi clade Open
Vibrios belonging to the Harveyi clade (including closely related species such as Vibrio campbellii , Vibrio harveyi and Vibrio parahaemolyticus ) are important pathogens of aquatic organisms. In this study, we investigated the use of indo…
View article: Indole analogues decreasing the virulence of <i>Vibrio campbellii</i> towards brine shrimp larvae
Indole analogues decreasing the virulence of <i>Vibrio campbellii</i> towards brine shrimp larvae Open
Indole signalling has been proposed as a potential target for the development of novel virulence inhibitors to control bacterial infections. However, the major structural features of indole analogues that govern antivirulence activity rema…
View article: Deciphering the virulent Vibrio harveyi causing spoilage in muscle of aquatic crustacean Litopenaeus vannamei
Deciphering the virulent Vibrio harveyi causing spoilage in muscle of aquatic crustacean Litopenaeus vannamei Open
View article: Halogenated Indoles Decrease the Virulence of Vibrio campbellii in a Gnotobiotic Brine Shrimp Model
Halogenated Indoles Decrease the Virulence of Vibrio campbellii in a Gnotobiotic Brine Shrimp Model Open
Bacterial diseases are a major problem in the aquaculture industry. In order to counter this problem, farmers have been using antibiotics, and this has led to the evolution and spread of antibiotic resistance.
View article: Indole decreases the virulence of the bivalve model pathogens Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9
Indole decreases the virulence of the bivalve model pathogens Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9 Open
Indole signaling plays an important role in bacterial pathogenesis. In this study, the impact of indole on biofilm formation, swimming and swarming motility were explored in Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9, two model…
View article: Quorum Sensing Regulation of Virulence Gene Expression in Vibrio harveyi during its Interaction with Marine Diatom Skeletonema marinoi
Quorum Sensing Regulation of Virulence Gene Expression in Vibrio harveyi during its Interaction with Marine Diatom Skeletonema marinoi Open
Communication between species from different kingdoms may be as important as intra-kingdom communication. It has recently been confirmed that co-existing bacteria and phytoplankton in aquatic ecosystems do cross-talk. This study examined t…
View article: The impact of the multichannel quorum sensing systems of Vibrio tasmaniensis and Vibrio crassostreae on virulence towards blue mussel (Mytilus edulis) larvae
The impact of the multichannel quorum sensing systems of Vibrio tasmaniensis and Vibrio crassostreae on virulence towards blue mussel (Mytilus edulis) larvae Open
View article: Insights into a Pyruvate Sensing and Uptake System in <i>Vibrio campbellii</i> and Its Importance for Virulence
Insights into a Pyruvate Sensing and Uptake System in <i>Vibrio campbellii</i> and Its Importance for Virulence Open
Bacterial infections are a serious threat to marine aquaculture, one of the fastest growing food sectors on earth. Therefore, it is extremely important to learn more about the pathogens responsible, one of which is Vibrio campbellii .
View article: One health pathogen surveillance demonstrated the dissemination of gut pathogens within the two coastal regions associated with intensive farming
One health pathogen surveillance demonstrated the dissemination of gut pathogens within the two coastal regions associated with intensive farming Open
Background Intensive aquaculture farming has caused significant degradation of coastal wetlands and has been proposed as a reservoir for pathogenic Vibrio spp. Results Gut pathogens including Vibrio spp., Salmonella spp., and Klebsiella sp…
View article: Probiotics: their action against pathogens can be turned around
Probiotics: their action against pathogens can be turned around Open
View article: Interfering with Bacterial Signalling Mechanisms as a Novel Strategy to Control Diseases – Aquaculture as a Case Study
Interfering with Bacterial Signalling Mechanisms as a Novel Strategy to Control Diseases – Aquaculture as a Case Study Open
Bacterial pathogens are quickly developing resistance to all known antibiotics. As a result, antibiotic treatments become ineffective, and diseases caused by antibiotic-resistant bacteria are currently a major cause of death worldwide. Bac…
View article: Additional file 1 of One health pathogen surveillance demonstrated the dissemination of gut pathogens within the two coastal regions associated with intensive farming
Additional file 1 of One health pathogen surveillance demonstrated the dissemination of gut pathogens within the two coastal regions associated with intensive farming Open
Additional file 1. Additional Tables.
View article: Rearing water microbiomes in white leg shrimp ( <scp> <i>Litopenaeus vannamei</i> </scp> ) larviculture assemble stochastically and are influenced by the microbiomes of live feed products
Rearing water microbiomes in white leg shrimp ( <span> <i>Litopenaeus vannamei</i> </span> ) larviculture assemble stochastically and are influenced by the microbiomes of live feed products Open
Summary The development of effective management strategies to reduce the occurrence of diseases in aquaculture is hampered by the limited knowledge on the microbial ecology of these systems. In this study, the dynamics and dominant communi…
View article: Rearing water microbiomes in white leg shrimp (<i>Litopenaeus vannamei</i>) larviculture assemble stochastically and are influenced by the microbiomes of live feed products
Rearing water microbiomes in white leg shrimp (<i>Litopenaeus vannamei</i>) larviculture assemble stochastically and are influenced by the microbiomes of live feed products Open
Summary The development of effective management strategies to reduce the occurrence of diseases in aquaculture is hampered by the limited knowledge on the microbial ecology of these systems. In this study, the dynamics and dominant communi…
View article: The blue mussel inside: 3D visualization and description of the vascular-related anatomy of Mytilus edulis to unravel hemolymph extraction
The blue mussel inside: 3D visualization and description of the vascular-related anatomy of Mytilus edulis to unravel hemolymph extraction Open
View article: 3D mussel model in aquaculture
3D mussel model in aquaculture Open
View article: Horizontal gene transfer of the<i>pirAB</i>genes responsible for Acute Hepatopancreatic Necrosis Disease (AHPND) turns a non-<i>Vibrio</i>strain into an AHPND-positive pathogen
Horizontal gene transfer of the<i>pirAB</i>genes responsible for Acute Hepatopancreatic Necrosis Disease (AHPND) turns a non-<i>Vibrio</i>strain into an AHPND-positive pathogen Open
In the past decade, shrimp farms, particularly those established in Asia, Mexico and South America suffered from the outbreak of an emergent penaeid shrimp disease known as Acute Hepatopancreatic Necrosis Disease (AHNPD). The PirA and PirB…
View article: Media Optimization, Strain Compatibility, and Low-Shear Modeled Microgravity Exposure of Synthetic Microbial Communities for Urine Nitrification in Regenerative Life-Support Systems
Media Optimization, Strain Compatibility, and Low-Shear Modeled Microgravity Exposure of Synthetic Microbial Communities for Urine Nitrification in Regenerative Life-Support Systems Open
Urine is a major waste product of human metabolism and contains essential macro- and micronutrients to produce edible microorganisms and crops. Its biological conversion into a stable form can be obtained through urea hydrolysis, subsequen…