Thomas M. Egan
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View article: Characterizing random complex biological media by quantifying ultrasound multiple scattering
Characterizing random complex biological media by quantifying ultrasound multiple scattering Open
Introduction: In this in silico, in vitro, and in vivo study, we propose metrics for the characterization of highly scattering media using backscattered acoustic waves in the MHz range, for application to the characterization of biological…
View article: Characterizing random complex biological media by quantifying ultrasound multiple scattering
Characterizing random complex biological media by quantifying ultrasound multiple scattering Open
Introduction: In this in silico , in vitro , and in vivo study, we propose metrics for the characterization of highly scattering media using backscattered acoustic waves in the MHz range, for application to the characterization of biologic…
View article: In vivo assessment of pulmonary fibrosis and edema in rodents using the backscatter coefficient and envelope statisticsa)
In vivo assessment of pulmonary fibrosis and edema in rodents using the backscatter coefficient and envelope statisticsa) Open
Quantitative ultrasound methods based on the backscatter coefficient (BSC) and envelope statistics have been used to quantify disease in a wide variety of tissues, such as prostate, lymph nodes, breast, and thyroid. However, to date, these…
View article: Evaluating a CTSA-funded pilot grant program
Evaluating a CTSA-funded pilot grant program Open
INTRODUCTION: Pilot programs are integral to catalyzing and accelerating research at Clinical and Translational Science Award (CTSA) hubs. However, little has been published about the structure and operationalization of pilot programs or h…
View article: Lung quantitative ultrasound to stage and monitor interstitial lung diseases
Lung quantitative ultrasound to stage and monitor interstitial lung diseases Open
Chronic interstitial lung diseases (ILDs) require frequent point-of-care monitoring. X-ray-based methods lack resolution and are ionizing. Chest computerized tomographic (CT) scans are expensive and provide more radiation. Conventional ult…
View article: Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair
Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair Open
Bioadhesive materials and patches are promising alternatives to surgical sutures and staples. However, many existing bioadhesives do not meet the functional requirements of current surgical procedures and interventions. Here, we present a …
View article: Design Optimization and Tradeoff Analysis of an Actuated Continuum Probe for Pulmonary Nodule Localization and Resection
Design Optimization and Tradeoff Analysis of an Actuated Continuum Probe for Pulmonary Nodule Localization and Resection Open
Pulmonary nodules are abnormal tissue masses in the lungs, typically less than 3.0 cm in diameter, commonly detected during imaging of the chest and lungs. While most pulmonary nodules are not cancerous, surgical resection may be required …
View article: Design Optimization and Tradeoff Analysis of an Actuated Continuum Probe for Pulmonary Nodule Localization and Resection
Design Optimization and Tradeoff Analysis of an Actuated Continuum Probe for Pulmonary Nodule Localization and Resection Open
Pulmonary nodules are abnormal tissue masses in the lungs, typically less than 3.0 cm in diameter, commonly detected during imaging of the chest and lungs. While most pulmonary nodules are not cancerous, surgical resection may be required …
View article: Outcomes Following Lung Transplant for COVID-19-Related Complications in the US
Outcomes Following Lung Transplant for COVID-19-Related Complications in the US Open
IMPORTANCE: The COVID-19 pandemic led to the use of lung transplant as a lifesaving therapy for patients with irreversible lung injury. Limited information is currently available regarding the outcomes associated with this treatment modali…
View article: Outcomes Following Lung Transplant for COVID-19–Related Complications in the US
Outcomes Following Lung Transplant for COVID-19–Related Complications in the US Open
Importance The COVID-19 pandemic led to the use of lung transplant as a lifesaving therapy for patients with irreversible lung injury. Limited information is currently available regarding the outcomes associated with this treatment modalit…
View article: Detecting pulmonary nodules by using ultrasound multiple scattering
Detecting pulmonary nodules by using ultrasound multiple scattering Open
Although X-Ray Computed Tomography (CT) is widely used for detecting pulmonary nodules inside the parenchyma, it cannot be used during video-assisted surgical procedures. Real-time, non-ionizing, ultrasound-based techniques are an attracti…
View article: <i>In vivo</i> assessment of pulmonary fibrosis and edema in rodents using the backscatter coefficient and envelope statistics
<i>In vivo</i> assessment of pulmonary fibrosis and edema in rodents using the backscatter coefficient and envelope statistics Open
Quantitative ultrasound methods based on the backscatter coefficient (BSC) and envelope statistics have been used to quantify disease in a wide variety of tissues, such as prostate, lymph nodes, breast, and thyroid. However, to date, these…
View article: Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non–heart-beating donors
Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non–heart-beating donors Open
If lungs could be retrieved from non–heart-beating donors, the critical shortage of lungs for transplantation could be alleviated. However, lungs subjected to warm ischemia develop edema when reperfused. We hypothesized that ventilation of…
View article: In vitro modeling of nonhypoxic cold ischemia–reperfusion simulating lung transplantation
In vitro modeling of nonhypoxic cold ischemia–reperfusion simulating lung transplantation Open
Although anoxia/reoxygenation of cultured cells has been employed to model lung ischemia-reperfusion injury (IRI), this does not accurately mimic events experienced by lung cells while a lung is retrieved from a donor, stored, and transpla…
View article: Lung retrieval from non–heart beating cadavers with the use of a rat lung transplant model
Lung retrieval from non–heart beating cadavers with the use of a rat lung transplant model Open
Background: Lungs retrieved from cadavers after death and circulatory arrest may alleviate the critical shortage of lungs for transplant. We report a rat lung transplantation model that allows serial measurement of arterial blood gases aft…
View article: Postmortem and ex vivo carbon monoxide ventilation reduces injury in rat lungs transplanted from non–heart-beating donors
Postmortem and ex vivo carbon monoxide ventilation reduces injury in rat lungs transplanted from non–heart-beating donors Open
OBJECTIVE: We sought to determine whether ventilation of lungs after death in non-heart-beating donors with carbon monoxide during warm ischemia and ex vivo lung perfusion and after transplant would reduce ischemia-reperfusion injury and i…
View article: Improved results of lung transplantation for patients with cystic fibrosis
Improved results of lung transplantation for patients with cystic fibrosis Open
Patients with cystic fibrosis pose particular challenges for lung transplantation surgeons. Earlier reports from North America centers suggested that patients with cystic fibrosis were greater risk for heart-lung or isolated lung transplan…
View article: Donation after circulatory death donors in lung transplantation
Donation after circulatory death donors in lung transplantation Open
Transplantation of any organ into a recipient requires a donor. Lung transplant has a long history of an inadequate number of suitable donors to meet demand, leading to deaths on the waiting list annually since national data was collected,…
View article: The real number of organs from uncontrolled donation after circulatory determination of death donors
The real number of organs from uncontrolled donation after circulatory determination of death donors Open
To the Editor: We write about Boyarsky et al’s estimate of uncontrolled Donation after Circulatory determination of Death donors (uDCDs)1Boyarsky BJ Jackson KR Kernodle AB et al.Estimating the potential pool of uncontrolled DCD donors in t…
View article: Evaluating a CTSA-funded pilot grant program
Evaluating a CTSA-funded pilot grant program Open
Introduction: Pilot programs are integral to catalyzing and accelerating research at Clinical and Translational Science Award (CTSA) hubs. However, little has been published about the structure and operationalization of pilot programs or h…
View article: In vitro modeling of nonhypoxic cold ischemia–reperfusion simulating lung transplantation
In vitro modeling of nonhypoxic cold ischemia–reperfusion simulating lung transplantation Open
Although anoxia/reoxygenation of cultured cells has been employed to model lung ischemia-reperfusion injury (IRI), this does not accurately mimic events experienced by lung cells while a lung is retrieved from a donor, stored, and transpla…
View article: Emergency medical services knowledge and attitudes about non-heart-beating donors: Effect of an educational intervention
Emergency medical services knowledge and attitudes about non-heart-beating donors: Effect of an educational intervention Open
More than 750,000 people die of sudden death each year, and many are potential non-heart-beating donors (NHBDs) for lung transplant. Although critical, the role of emergency medical services (EMS) personnel in assisting with recovery of NH…
View article: Assessment of Real-Time 3D Visualization for Cardiothoracic Diagnostic Evaluation and Surgery Planning
Assessment of Real-Time 3D Visualization for Cardiothoracic Diagnostic Evaluation and Surgery Planning Open
RATIONALE AND OBJECTIVES: Three-dimensional (3D) real-time volume rendering has demonstrated improvements in clinical care for several areas of radiological imaging. We test whether advanced real-time rendering techniques combined with an …
View article: Lung Transplantation: Opportunities for Research and Clinical Advancement
Lung Transplantation: Opportunities for Research and Clinical Advancement Open
Lung transplantation is the only definitive therapy for many forms of end-stage lung diseases. However, the success of lung transplantation is limited by many factors: (1) Too few lungs available for transplantation due to limited donors o…