Tom C. Hu
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View article: <scp>TFE3</scp> ‐Rearranged <scp>PEComa</scp> (‐Like Neoplasm) of the Chest Wall Diagnosed by Fine‐Needle Aspiration: A Case Report
<span>TFE3</span> ‐Rearranged <span>PEComa</span> (‐Like Neoplasm) of the Chest Wall Diagnosed by Fine‐Needle Aspiration: A Case Report Open
We report a rare TFE3‐rearranged perivascular epithelioid cell tumor (PEComa) of the parasternal chest wall diagnosed preoperatively by fine‐needle aspiration (FNA) cytology. The smears and cell block showed epithelioid cells with clear to…
View article: Pathologist-interpretable breast cancer subtyping and stratification from AI-inferred nuclear features
Pathologist-interpretable breast cancer subtyping and stratification from AI-inferred nuclear features Open
Artificial intelligence (AI) is making notable advances in digital pathology but faces challenges in human interpretability. Here we introduce EXPAND ( EX plainable P athologist A ligned N uclear D iscriminator), the first pathologist-inte…
View article: AI-Driven Spatial Transcriptomics Unlocks Large-Scale Breast Cancer Biomarker Discovery from Histopathology
AI-Driven Spatial Transcriptomics Unlocks Large-Scale Breast Cancer Biomarker Discovery from Histopathology Open
Spatial transcriptomics (ST) is transforming our understanding of tumor heterogeneity by enabling high-resolution, location-specific mapping of gene expression across tumors and their microenvironment. However, the associated high cost of …
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View article: Supplementary Figure 1 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 1 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 164K, Characterization of W2671T and W2830T murine ovarian carcinoma cell lines. Phase contrast photomicrographs showing epithelial-like cobblestone morphology of mouse ovarian carcinoma-derived cell lines A) W2671T and B) W2830…
View article: Data from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Data from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
Purpose: Genetically engineered mouse (GEM) models of ovarian cancer that closely recapitulate their human tumor counterparts may be invaluable tools for preclinical testing of novel therapeutics. We studied murine ovarian endometrioid ade…
View article: Data from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Data from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
Purpose: Genetically engineered mouse (GEM) models of ovarian cancer that closely recapitulate their human tumor counterparts may be invaluable tools for preclinical testing of novel therapeutics. We studied murine ovarian endometrioid ade…
View article: Supplementary Figure Legends 1-3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure Legends 1-3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 75K
View article: Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 111K, Characterization of PI3K/Akt/mTOR and Erk signaling pathway regulation in human ovarian cancer cells after treatment with mTOR inhibitor rapamycin. Immunoblots showing dose-dependent effect of rapamycin (0.01 - 100nM) on p…
View article: Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 111K, Characterization of PI3K/Akt/mTOR and Erk signaling pathway regulation in human ovarian cancer cells after treatment with mTOR inhibitor rapamycin. Immunoblots showing dose-dependent effect of rapamycin (0.01 - 100nM) on p…
View article: Supplementary Figure 1 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 1 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 164K, Characterization of W2671T and W2830T murine ovarian carcinoma cell lines. Phase contrast photomicrographs showing epithelial-like cobblestone morphology of mouse ovarian carcinoma-derived cell lines A) W2671T and B) W2830…
View article: Supplementary Figure Legends 1-3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure Legends 1-3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 75K
View article: Supplementary Figure 3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 3.4MB, Inhibition of S6 phosphorylation in APC-/PTEN- murine ovarian tumors by rapamycin in vivo. Immunoblot of lysates from primary tumor tissues from mice treated for 4 weeks with vehicle (V1, 2, 3), 1 mg/kg (R1) or 4 mg/kg (R…
View article: Supplementary Figure 3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 3.4MB, Inhibition of S6 phosphorylation in APC-/PTEN- murine ovarian tumors by rapamycin in vivo. Immunoblot of lysates from primary tumor tissues from mice treated for 4 weeks with vehicle (V1, 2, 3), 1 mg/kg (R1) or 4 mg/kg (R…
View article: Granulocyte Colony-Stimulating Factor (Neupogen®; Filgrastim) Accelerates Neutrophil Recovery in a Rodent Model of Sulfur Mustard-Induced Hematologic Toxicity
Granulocyte Colony-Stimulating Factor (Neupogen®; Filgrastim) Accelerates Neutrophil Recovery in a Rodent Model of Sulfur Mustard-Induced Hematologic Toxicity Open
Objective: Evidence of myelosuppression has been negatively correlated with patient outcomes following cases of high dose sulfur mustard (SM) exposure. These hematologic complications can negatively impact overall immune function and incre…
View article: Overlapping Science in Radiation and Sulfur Mustard Exposures of Skin and Lung: Consideration of Models, Mechanisms, Organ Systems, and Medical Countermeasures: Overlapping science in radiation and sulfur mustard injuries to lung and skin
Overlapping Science in Radiation and Sulfur Mustard Exposures of Skin and Lung: Consideration of Models, Mechanisms, Organ Systems, and Medical Countermeasures: Overlapping science in radiation and sulfur mustard injuries to lung and skin Open
Purpose: To summarize presentations and discussions from the 2022 trans-agency workshop titled “Overlapping science in radiation and sulfur mustard (SM) exposures of skin and lung: Consideration of models, mechanisms, organ systems, and me…
View article: Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse
Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse Open
Endometrioid carcinoma ( EC ) is a relatively indolent ovarian carcinoma subtype that is nonetheless deadly if detected late. Existing genetically engineered mouse models ( GEMMs ) of the disease, based on transformation of the ovarian sur…