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View article: Shear-Wave Anisotropy of the Vastus Lateralis During Low-Level Isometric Contraction Measured with Ultrasound Time-Harmonic Elastography
Shear-Wave Anisotropy of the Vastus Lateralis During Low-Level Isometric Contraction Measured with Ultrasound Time-Harmonic Elastography Open
Purpose Skeletal muscle is commonly modeled as a transverse isotropic medium, however, the behavior of its anisotropy under active loading remains insufficiently characterized. In this study we used ultrasound time-harmonic elastography (T…
View article: Liver Viscosity Decreases Before the Onset of Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Liver Viscosity Decreases Before the Onset of Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis (MASH) Open
Background and Aim Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly prevalent condition worldwide, associated with biomechanical liver changes and detectable by magnetic resonance elastography (MRE). This study ex…
View article: Muscle activation assessment using ultrasound time-harmonic elastography and tonic vibration reflex*
Muscle activation assessment using ultrasound time-harmonic elastography and tonic vibration reflex* Open
Background Muscle activation is associated with increased tissue stiffness as measured by elastography in diagnostic applications. For this reason, we present ultrasound time-harmonic elastography (THE) applied to the vastus lateralis (VL)…
View article: In Vivo Wideband MR Elastography for Assessing Age-Related Viscoelastic Changes of the Human Brain
In Vivo Wideband MR Elastography for Assessing Age-Related Viscoelastic Changes of the Human Brain Open
Magnetic Resonance Elastography (MRE) noninvasively maps brain biomechanics and is highly sensitive to alterations associated with aging and neurodegenerative disease. Most implementations use a single frequency or a narrow frequency band,…
View article: Technical Recommendation on Multi-Driver Multifrequency MR Elastography for Tomographic Mapping of Abdominal Stiffness With a Focus on the Pancreas and Pancreatic Ductal Adenocarcinoma
Technical Recommendation on Multi-Driver Multifrequency MR Elastography for Tomographic Mapping of Abdominal Stiffness With a Focus on the Pancreas and Pancreatic Ductal Adenocarcinoma Open
Objectives: MR elastography (MRE) offers valuable mechanical tissue characterization for clinical diagnosis. However, conventional single-driver, single-frequency MRE systems are often limited by insufficient coverage of deep-seated organs…
View article: Time‐resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration
Time‐resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration Open
Purpose There is a clinical need for stiffness mapping of the heart; however, current cardiac magnetic resonance elastography (cMRE) has limited spatiotemporal resolution. Therefore, we developed 2D spiral multifrequency MRE of the human h…
View article: ElastoNet: Neural network-based multicomponent MR elastography wave inversion with uncertainty quantification
ElastoNet: Neural network-based multicomponent MR elastography wave inversion with uncertainty quantification Open
Magnetic Resonance Elastography (MRE) quantifies soft tissue stiffness by measuring induced shear waves. MRE inversion techniques for parameter reconstruction are often affected by noise and compression waves. Neural network-based inversio…
View article: Establishment of multifrequency magnetic resonance elastography for adrenal gland imaging: feasibility and reproducibility for assessing stiffness and fluidity in the healthy adrenal gland
Establishment of multifrequency magnetic resonance elastography for adrenal gland imaging: feasibility and reproducibility for assessing stiffness and fluidity in the healthy adrenal gland Open
Multifrequency MRE provides direct analysis of viscoelasticity of the adrenal glands on high-resolution elastograms with an excellent repeatability, providing direct analysis of small organs such as the adrenal glands directly on the elast…
View article: Association of In Vivo Kidney Stiffness Measured by Multifrequency <scp>MR</scp> Elastography and Long‐Term Renal Function in Transplant Recipients and Living Donors
Association of In Vivo Kidney Stiffness Measured by Multifrequency <span>MR</span> Elastography and Long‐Term Renal Function in Transplant Recipients and Living Donors Open
Background Kidney transplant (KTx) function assessment is important in treatment planning, while conventional MRI markers lack sensitivity for KTx function. Mechanical kidney properties may serve as MRI markers for renal allograft function…
View article: Automated liver and spleen segmentation for MR elastography maps using U-Nets
Automated liver and spleen segmentation for MR elastography maps using U-Nets Open
To compare pretrained and trained U-Nets for liver and spleen segmentation in multifrequency magnetic resonance elastography (MRE) magnitude images for automated quantification of shear wave speed (SWS). Seventy-two healthy participants (3…
View article: Noninvasive assessment of portal pressure by combined measurement of volumetric strain and stiffness of in vivo human liver
Noninvasive assessment of portal pressure by combined measurement of volumetric strain and stiffness of in vivo human liver Open
Liver metabolism depends on the mechanical interplay between the solid tissue matrix and blood vessels, making shear modulus and pressure important variables of hepatic homeostasis. While shear modulus can be quantified by magnetic resonan…
View article: Deep-Learning-Based Reconstruction of Single-Breath-Hold 3 mm HASTE Improves Abdominal Image Quality and Reduces Acquisition Time: A Quantitative Analysis
Deep-Learning-Based Reconstruction of Single-Breath-Hold 3 mm HASTE Improves Abdominal Image Quality and Reduces Acquisition Time: A Quantitative Analysis Open
Purpose: Breath-hold T2-weighted half-Fourier acquisition single-shot turbo spin echo (HASTE) magnetic resonance imaging (MRI) of the upper abdomen with a slice thickness below 5 mm suffers from high image noise and blurring. The purpose o…
View article: Myocardial stiffness - not just a matter of wall thickness
Myocardial stiffness - not just a matter of wall thickness Open
Background/Introduction Heart failure, including HFpEF, is a growing global health problem. Diastolic dysfunction (DD) is a critical component of HFpEF and is mainly caused by increased myocardial stiffness(1). Current cardiac elastography…
View article: Rapid Stiffness Mapping in Soft Biologic Tissues With Micrometer Resolution Using Optical Multifrequency Time‐Harmonic Elastography
Rapid Stiffness Mapping in Soft Biologic Tissues With Micrometer Resolution Using Optical Multifrequency Time‐Harmonic Elastography Open
Rapid mapping of the mechanical properties of soft biological tissues from light microscopy to macroscopic imaging can transform fundamental biophysical research by providing clinical biomarkers to complement in vivo elastography. This wor…
View article: Cardiac Elastography With External Vibration for Quantification of Diastolic Myocardial Stiffness
Cardiac Elastography With External Vibration for Quantification of Diastolic Myocardial Stiffness Open
Cardiac THE detects abnormal myocardial stiffness in patients with DD with high penetration depth, independent of body mass index and region selection. Based on standard ultrasound components, cardiac THE is cost-effective and has the pote…
View article: Multimodal assessment of brain stiffness variation in healthy subjects using magnetic resonance elastography and ultrasound time-harmonic elastography
Multimodal assessment of brain stiffness variation in healthy subjects using magnetic resonance elastography and ultrasound time-harmonic elastography Open
Magnetic resonance elastography (MRE) is a noninvasive method for mapping brain stiffness. Ultrasound-based transtemporal time-harmonic elastography (THE) is emerging as a cost-effective, fast alternative to MRE that has the potential to b…
View article: Rapid wideband characterization of viscoelastic material properties by Bessel function-based time harmonic ultrasound elastography (B-THE)
Rapid wideband characterization of viscoelastic material properties by Bessel function-based time harmonic ultrasound elastography (B-THE) Open
Elastography is an emerging diagnostic technique that uses conventional imaging modalities such as sonography or magnetic resonance imaging to quantify tissue stiffness. However, different elastography methods provide different stiffness v…
View article: In vivo characterization of brain tumor biomechanics: magnetic resonance elastography in intracranial B16 melanoma and GL261 glioma mouse models
In vivo characterization of brain tumor biomechanics: magnetic resonance elastography in intracranial B16 melanoma and GL261 glioma mouse models Open
Introduction Magnetic Resonance Elastography (MRE) allows the non-invasive quantification of tumor biomechanical properties in vivo . With increasing incidence of brain metastases, there is a notable absence of appropriate preclinical mode…
View article: Magnetic resonance elastography in a nutshell: Tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation
Magnetic resonance elastography in a nutshell: Tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation Open
Magnetic resonance elastography (MRE) is an emerging clinical imaging modality for characterizing the viscoelastic properties of soft biological tissues. MRE shows great promise in the noninvasive diagnosis of various diseases, especially …
View article: On the relationship between viscoelasticity and water diffusion in soft biological tissues
On the relationship between viscoelasticity and water diffusion in soft biological tissues Open
Magnetic resonance elastography (MRE) and diffusion-weighted imaging (DWI) are complementary imaging techniques that detect disease based on viscoelasticity and water mobility, respectively. However, the relationship between viscoelasticit…
View article: Point-of-care cardiac elastography with external vibration for quantification of diastolic myocardial stiffness
Point-of-care cardiac elastography with external vibration for quantification of diastolic myocardial stiffness Open
Background Heart failure is an increasing health problem in Western societies. Approximately 50% of patients with heart failure have preserved ejection fraction (HFpEF) and concomitant diastolic dysfunction (DD), in part caused by increase…
View article: Optical time-harmonic elastography for multiscale stiffness mapping across the phylogenetic tree
Optical time-harmonic elastography for multiscale stiffness mapping across the phylogenetic tree Open
Rapid mapping of the mechanical properties of soft biological tissues from light microscopy to macroscopic imaging could transform fundamental biophysical research by providing clinical biomarkers to complement in vivo elastography. We her…
View article: Rapid <scp>MR</scp> elastography of the liver for subsecond stiffness sampling
Rapid <span>MR</span> elastography of the liver for subsecond stiffness sampling Open
Purpose Depicting the stiffness of biological soft tissues, MR elastography (MRE) has a wide range of diagnostic applications. The purpose of this study was to improve the temporal resolution of 2D hepatic MRE in order to provide more rapi…
View article: Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography
Stiffness pulsation of the human brain detected by non-invasive time-harmonic elastography Open
Introduction: Cerebral pulsation is a vital aspect of cerebral hemodynamics. Changes in arterial pressure in response to cardiac pulsation cause cerebral pulsation, which is related to cerebrovascular compliance and cerebral blood perfusio…