Tom Pieper
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View article: Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high‐grade brain tumors: Results from a European survey
Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high‐grade brain tumors: Results from a European survey Open
Objective Epilepsy surgery is a standard treatment for drug‐resistant epilepsy, resulting in seizure freedom in a significant number of cases. Although frequently performed for low‐grade brain tumors, it is rarely considered for high‐grade…
View article: Age‐dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy
Age‐dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy Open
Objective Perineuronal nets (PNN) are specialized extracellular matrix (ECM) components of the central nervous system, frequently accumulating at the surface of inhibitory GABAergic interneurons. While an altered distribution of PNN has be…
View article: Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue
Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue Open
This study shows that seizure freedom can be reached in 40% of nonlesional patients with both normal MRI and histopathology findings. In particular, nonlesional temporal lobe epilepsy should be regarded as a relatively favorable group, wit…
View article: Ganglioglioma with adverse clinical outcome and atypical histopathological features were defined by alterations in PTPN11/KRAS/NF1 and other RAS-/MAP-Kinase pathway genes
Ganglioglioma with adverse clinical outcome and atypical histopathological features were defined by alterations in PTPN11/KRAS/NF1 and other RAS-/MAP-Kinase pathway genes Open
Exome-wide sequencing studies recently described PTPN11 as a novel brain somatic epilepsy gene. In contrast, germline mutations of PTPN11 are known to cause Noonan syndrome, a multisystem disorder characterized by abnormal facial features,…
View article: A deep learning-based histopathology classifier for Focal Cortical Dysplasia
A deep learning-based histopathology classifier for Focal Cortical Dysplasia Open
A light microscopy-based histopathology diagnosis of human brain specimens obtained from epilepsy surgery remains the gold standard to confirm the underlying cause of a patient’s focal epilepsy and further inform postsurgical patient manag…
View article: The genomic landscape across 474 surgically accessible epileptogenic human brain lesions
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions Open
Understanding the exact molecular mechanisms involved in the aetiology of epileptogenic pathologies with or without tumour activity is essential for improving treatment of drug-resistant focal epilepsy. Here, we characterize the landscape …
View article: The genomic landscape across 474 surgically accessible epileptogenic human brain lesions
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions Open
Understanding the exact molecular mechanisms involved in the etiology of epileptogenic pathologies with or without tumor activity is essential for improving treatment of drug-resistant focal epilepsy. Here, we characterize the landscape of…
View article: Variable histopathology features of neuronal dyslamination in the cerebral neocortex adjacent to epilepsy‐associated vascular malformations suggest complex pathogenesis of focal cortical dysplasia ILAE type IIIc
Variable histopathology features of neuronal dyslamination in the cerebral neocortex adjacent to epilepsy‐associated vascular malformations suggest complex pathogenesis of focal cortical dysplasia ILAE type IIIc Open
Focal cortical dysplasia type IIIc (FCD‐IIIc) is histopathologically defined by the International League Against Epilepsy's classification scheme as abnormal cortical organization adjacent to epilepsy‐associated vascular malformations (VM)…
View article: DNA methylation-based classification of malformations of cortical development in the human brain
DNA methylation-based classification of malformations of cortical development in the human brain Open
Malformations of cortical development (MCD) comprise a broad spectrum of structural brain lesions frequently associated with epilepsy. Disease definition and diagnosis remain challenging and are often prone to arbitrary judgment. Molecular…
View article: Correlates of intellectual development before and after hemispherotomy: an analysis of 75 children and adolescents
Correlates of intellectual development before and after hemispherotomy: an analysis of 75 children and adolescents Open
This study describes the intellectual development of 75 children and adolescents who underwent hemispherotomy. Furthermore, we aimed to reveal predicting factors on pre- and postsurgical development with a focus on the role of aetiology. W…
View article: Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay
Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay Open
Polymicrogyria (PMG) is a developmental cortical malformation characterized by an excess of small and frustrane gyration and abnormal cortical lamination. PMG frequently associates with seizures. The molecular pathomechanisms underlying PM…
View article: Genomic <scp>DNA</scp> methylation distinguishes subtypes of human focal cortical dysplasia
Genomic <span>DNA</span> methylation distinguishes subtypes of human focal cortical dysplasia Open
Objectives Focal cortical dysplasia ( FCD ) is a major cause of drug‐resistant focal epilepsy in children, and the clinicopathological classification remains a challenging issue in daily practice. With the recent progress in DNA methylatio…
View article: Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis
Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis Open
CD8+ T cells were until now considered the central players in the immunopathogenesis of RE. Our study adds to previous findings and highlights that CD4+ TCCs and γδ T cells that secrete IFN-γ and TNF are also involved. These findings under…
View article: Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery
Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery Open
In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were th…
View article: Predicting hand function after hemidisconnection
Predicting hand function after hemidisconnection Open
Hemidisconnections (i.e. hemispherectomies or hemispherotomies) invariably lead to contralateral hemiparesis. Many patients with a pre-existing hemiparesis, however, experience no deterioration in motor functions, and some can still grasp …
View article: Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Frontal Lobe Epilepsy: A New Clinico‐Pathological Entity
Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Frontal Lobe Epilepsy: A New Clinico‐Pathological Entity Open
The histopathological spectrum of human epileptogenic brain lesions is widespread including common and rare variants of cortical malformations. However, 2–26% of epilepsy surgery specimens are histopathologically classified as nonlesional.…
View article: EPILEPSY SURGERY IN PATIENTS WITH TUBEROUS SCLEROSIS
EPILEPSY SURGERY IN PATIENTS WITH TUBEROUS SCLEROSIS Open
With a few exceptions patients with tuberous sclerosis (TS) suffering from drug-resistant epilepsies have potentially epileptogenic lesionswithin both hemispheres. Until one decade ago in general such a constellation was an xclusion criter…