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View article: Early blood pressure lowering and cerebral oedema in thrombolysis-treated stroke: secondary analysis of the ENCHANTED trial
Early blood pressure lowering and cerebral oedema in thrombolysis-treated stroke: secondary analysis of the ENCHANTED trial Open
Background and purpose Controversy persists over the balance of benefits and harms of early intensive blood pressure (BP) lowering in thrombolysis-treated acute ischaemic stroke (AIS) patients. The BP-control arm of the Enhanced Control of…
View article: The influence of dynamic cerebral autoregulation efficiency on its directional sensitivity
The influence of dynamic cerebral autoregulation efficiency on its directional sensitivity Open
Dynamic cerebral autoregulation (dCA) is more efficient for increases in mean arterial blood pressure (MAP) compared with reductions in MAP. We found that directional sensitivity of dCA is dependent on its efficiency, with differences depe…
View article: Improving access to physical healthcare for older people in mental health settings: the ImPreSs-care qualitative study
Improving access to physical healthcare for older people in mental health settings: the ImPreSs-care qualitative study Open
Background Older people with serious mental ill health have high levels of physical comorbidity. Despite this, mental health services receive limited physical health support from primary or secondary care. This study investigated the facil…
View article: Trajectory of Hematoma Growth and Functional Recovery after Intracerebral Hemorrhage: A Latent Class Analysis of Blood Pressure in Acute Stroke Collaboration Data
Trajectory of Hematoma Growth and Functional Recovery after Intracerebral Hemorrhage: A Latent Class Analysis of Blood Pressure in Acute Stroke Collaboration Data Open
Introduction: Moderate blood pressure (BP) reduction reduces hematoma growth, but this has not been shown to translate into improved functional recovery after intracerebral hemorrhage (ICH). This study aimed to define patient profiles acco…
View article: Can we identify stroke sub-type without imaging? A multidimensional analysis
Can we identify stroke sub-type without imaging? A multidimensional analysis Open
Stroke is a major cause of mortality and disability worldwide, with ischemic stroke (AIS) and intracerebral haemorrhage (ICH) requiring distinct management approaches. Accurate early detection and differentiation of these subtypes is cruci…
View article: Tuning the band gap and structure from wide gap SrBi<sub>3</sub>O<sub>4</sub>Cl<sub>3</sub> to narrow gap Bi<sub>4</sub>O<sub>4</sub>SeCl<sub>2</sub> by aliovalent anion substitution
Tuning the band gap and structure from wide gap SrBi<sub>3</sub>O<sub>4</sub>Cl<sub>3</sub> to narrow gap Bi<sub>4</sub>O<sub>4</sub>SeCl<sub>2</sub> by aliovalent anion substitution Open
Aliovalent substitution can generates a complex solid solution between SrBi 3 O 4 Cl 3 and Bi 4 O 4 SeCl 2 with very different band gaps, leading to a nearly isolated Se p band and two distinct band-gap like onset energies in intermediate …
View article: Statistical Analysis Plan for the Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMIST)
Statistical Analysis Plan for the Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMIST) Open
1 Abstract The OPTIMIST trial aims to determine whether low-intensity monitoring is at least as effective (“non-inferior”) to standard monitoring, on the functional recovery of patients who have received recombinant tissue plasminogen acti…
View article: Influence of renal function on blood pressure control and outcome in thrombolyzed patients after acute ischemic stroke: post-hoc analysis of the ENCHANTED trial
Influence of renal function on blood pressure control and outcome in thrombolyzed patients after acute ischemic stroke: post-hoc analysis of the ENCHANTED trial Open
Background The effect of renal impairment in patients who receive intravenous thrombolysis for acute ischemic stroke (AIS) is unclear. We aimed to determine the associations of renal impairment and clinical outcomes and any modification of…
View article: Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke
Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke Open
ClinicalTrials.gov (NCT01422616).
View article: Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the <scp>RIGHT</scp>‐2 trial
Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the <span>RIGHT</span>‐2 trial Open
Background and purpose Ambulance trials assessing interventions in suspected stroke patients will recruit patients with currently active symptoms that will resolve into transient ischaemic attack (TIA). The safety and efficacy of glyceryl …
View article: Twenty‐Four‐Hour Post‐Thrombolysis NIHSS Score As the Strongest Prognostic Predictor After Acute Ischemic Stroke: ENCHANTED Study
Twenty‐Four‐Hour Post‐Thrombolysis NIHSS Score As the Strongest Prognostic Predictor After Acute Ischemic Stroke: ENCHANTED Study Open
Background This study was conducted to determine optimal predictive ability of National Institutes of Health Stroke Scale (NIHSS) measurements at baseline, 24 hours, and change from baseline to 24 hours after thrombolysis on functional rec…
View article: The effect of posture on the age dependence of neurovascular coupling
The effect of posture on the age dependence of neurovascular coupling Open
Previous studies report contradicting age‐related neurovascular coupling (NVC). Few studies assess postural effects, but less investigate relationships between age and NVC within different postures. Therefore, this study investigated the e…
View article: Integrated Physical‐Mental Healthcare Services in Specialist Settings to Improve Outcomes for Older People Living With Mental Health Diagnoses: A Systematic Review
Integrated Physical‐Mental Healthcare Services in Specialist Settings to Improve Outcomes for Older People Living With Mental Health Diagnoses: A Systematic Review Open
Background Many older people are now living with co‐occurring physical and mental health disorders, but these often managed separately. The aim of this systematic review was to explore integrated physical‐mental health care services availa…
View article: Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement
Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement Open
Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task act…
View article: Tuning the band gap and structure from wide gap SrBi3O4Cl3 to narrow gap Bi4O4SeCl2 by aliovalent anion substitution
Tuning the band gap and structure from wide gap SrBi3O4Cl3 to narrow gap Bi4O4SeCl2 by aliovalent anion substitution Open
Modifying the atomic and electronic structure of materials by chemical substitution is a common method of achieving properties by design. Cations and metal atoms are the most frequent choices for chemical substitution; replacing anions wit…
View article: Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial
Outcome 1 year after ICH: Data from the Tranexamic acid for IntraCerebral Haemorrhage 2 (TICH-2) trial Open
Introduction: The Tranexamic acid for IntraCerebral Haemorrhage-2 (TICH-2) trial reported no significant improvement in death and dependency at day 90 despite reductions in haematoma expansion, early neurological deterioration and early de…
View article: Design and deployment of the STEEER-AF trial to evaluate and improve guideline adherence: a cluster-randomized trial by the European Society of Cardiology and European Heart Rhythm Association
Design and deployment of the STEEER-AF trial to evaluate and improve guideline adherence: a cluster-randomized trial by the European Society of Cardiology and European Heart Rhythm Association Open
Aims The aim is to describe the rationale, design, delivery, and baseline characteristics of the Stroke prevention and rhythm control Treatment: Evaluation of an Educational programme of the European society of cardiology in a cluster-Rand…
View article: Determinants of the dynamic cerebral critical closing pressure response to changes in mean arterial pressure
Determinants of the dynamic cerebral critical closing pressure response to changes in mean arterial pressure Open
Objective . Cerebral critical closing pressure (CrCP) represents the value of arterial blood pressure (BP) where cerebral blood flow (CBF) becomes zero. Its dynamic response to a step change in mean BP (MAP) has been shown to reflect CBF a…
View article: Internalized Homonegativity is Indirectly Associated with Smoking Status through Somatic Anxiety
Internalized Homonegativity is Indirectly Associated with Smoking Status through Somatic Anxiety Open
Objective: In this study, we examined how internalized homonegativity (IH), a non-adaptive cognitive response to lesbian, gay, and bisexual (LGB) minority stressors, related to the manifestation of somatic anxiety symptoms and reduced the …
View article: The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial
The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial Open
BACKGROUND AND OBJECTIVES: An important proportion of patients with spontaneous intracerebral hemorrhage (ICH) undergo neurosurgical intervention to reduce mass effect from large hematomas and control the complications of bleeding, includi…
View article: Attitudes of cardiac rehabilitation and stroke teams towards integration of stroke survivors into adapted cardiac rehabilitation: A focus group study
Attitudes of cardiac rehabilitation and stroke teams towards integration of stroke survivors into adapted cardiac rehabilitation: A focus group study Open
Objective To explore the attitudes and beliefs of cardiac rehabilitation and stroke teams towards adapted cardiac rehabilitation, and the broader topics of exercise, healthy lifestyles and health behaviour change, for people with mild-to-m…
View article: A Multi-Parametric Approach for Characterising Cerebral Haemodynamics in Acute Ischaemic and Haemorrhagic Stroke
A Multi-Parametric Approach for Characterising Cerebral Haemodynamics in Acute Ischaemic and Haemorrhagic Stroke Open
Background and Purpose: Early differentiation between acute ischaemic (AIS) and haemorrhagic stroke (ICH), based on cerebral and peripheral hemodynamic parameters, would be advantageous to allow for pre-hospital interventions. In this prel…
View article: Rates, risks and routes to reduce vascular dementia (R4VaD), a UK-wide multicentre prospective observational cohort study of cognition after stroke: baseline data and statistical analysis plan (ISRCTN18274006)
Rates, risks and routes to reduce vascular dementia (R4VaD), a UK-wide multicentre prospective observational cohort study of cognition after stroke: baseline data and statistical analysis plan (ISRCTN18274006) Open
Background Stroke is often followed by vascular cognitive impairment and vascular dementia; these are the most feared complication of stroke. However, there is limited understanding of post-stroke cognitive impairment. Methods Rates, Risks…
View article: Physiological Variability during Prehospital Stroke Care: Which Monitoring and Interventions Are Used?
Physiological Variability during Prehospital Stroke Care: Which Monitoring and Interventions Are Used? Open
Prehospital care is a fundamental component of stroke care that predominantly focuses on shortening the time between diagnosis and reaching definitive stroke management. With growing evidence of the physiological parameters affecting long-…
View article: Individual Patient Data Meta-Analysis of Dynamic Cerebral Autoregulation and Functional Outcome After Ischemic Stroke
Individual Patient Data Meta-Analysis of Dynamic Cerebral Autoregulation and Functional Outcome After Ischemic Stroke Open
BACKGROUND: The relationship between dynamic cerebral autoregulation (dCA) and functional outcome after acute ischemic stroke (AIS) is unclear. Previous studies are limited by small sample sizes and heterogeneity. METHODS: We performed a 1…