Tom Ruffles
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View article: Quality standards for paediatric bronchiectasis care in the UK, a national study
Quality standards for paediatric bronchiectasis care in the UK, a national study Open
The recent quality standards for paediatric bronchiectasis are a useful benchmarking tool for newly established services. They can be achieved with innovative individual practice. https://bit.ly/42B4S5l.
View article: <scp> <i>ADRB2</i> </scp> genotype‐guided treatment for childhood asthma: Cost analysis of the <scp>PUFFIN</scp> and <scp>PACT</scp> trials
<span> <i>ADRB2</i> </span> genotype‐guided treatment for childhood asthma: Cost analysis of the <span>PUFFIN</span> and <span>PACT</span> trials Open
Background Long‐acting β2‐agonists (LABA) are commonly used to treat asthma. Some children do not respond well to LABA, which may be due to +46G>A−/rs1042713 (Arg16 amino acid) in the ADRB2 gene encoding the β2 receptor. Arg16Gly ADRB2 gen…
View article: Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two Randomized Control Trials
Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two Randomized Control Trials Open
Background Long‐acting beta2‐agonists (LABA) in combination with inhaled corticosteroids (ICS) are commonly used to treat asthma, however, some children lack response to the addition of LABA. This might be partially due to the presence of …
View article: Environmental risk factors for respiratory infection and wheeze in young children: A multicentre birth cohort study
Environmental risk factors for respiratory infection and wheeze in young children: A multicentre birth cohort study Open
Introduction Respiratory infections and wheeze have a considerable impact on the health of young children and consume significant healthcare resources. We aimed to evaluate the effect of environmental factors on respiratory infections and …
View article: Mannose‐binding lectin genotype is associated with respiratory disease in young children: A multicenter cohort study
Mannose‐binding lectin genotype is associated with respiratory disease in young children: A multicenter cohort study Open
Background Mannose‐binding lectin (MBL) is an important component of the innate immune system. Polymorphisms in the MBL2 gene and promoter region are directly associated with MBL‐deficiency. We sought to determine the association between M…
View article: Considerations of a real life pragmatic clinical trial in adolescent asthma
Considerations of a real life pragmatic clinical trial in adolescent asthma Open
We appreciate the interest shown by J.F.M. van Boven and co-workers in our study. PACT [1] was first and foremost designed as a pragmatic randomised controlled trial (RCT) reflecting current UK primary care practice. While addition of cont…
View article: Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents
Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents Open
Introduction The A allele of rs1042713 (Arg16 amino acid) in the β 2 -adrenoreceptor is associated with poor response to long-acting β 2 -agonist (LABA) in young people with asthma. Our aim was to assess whether the prescribing of second-l…
View article: Outcomes of protracted bacterial bronchitis in children: A 5‐year prospective cohort study
Outcomes of protracted bacterial bronchitis in children: A 5‐year prospective cohort study Open
Background and objective Long‐term data on children with PBB has been identified as a research priority. We describe the 5‐year outcomes for children with PBB to ascertain the presence of chronic respiratory disease (bronchiectasis, recurr…