Tom Ryu
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View article: Class-Specific Effects of ARBs Versus ACE Inhibitors on Survival and Cardiovascular Outcomes in MASLD
Class-Specific Effects of ARBs Versus ACE Inhibitors on Survival and Cardiovascular Outcomes in MASLD Open
Renin–angiotensin system (RAS) inhibitors, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), have been associated with improved outcomes in metabolic dysfunction-associated steatotic li…
View article: Alcohol-Induced Oxidative Stress and Gut–Liver–Brain Crosstalk: Expanding the Paradigm from ALD to MetALD
Alcohol-Induced Oxidative Stress and Gut–Liver–Brain Crosstalk: Expanding the Paradigm from ALD to MetALD Open
Alcohol-associated liver disease (ALD) includes a spectrum from steatosis and steatohepatitis to cirrhosis and hepatocellular carcinoma driven by oxidative stress, immune activation, and systemic inflammation. Ethanol metabolism through al…
View article: The prognostic impact of statin exposure in metabolic dysfunction-associated steatotic liver disease: a cohort study
The prognostic impact of statin exposure in metabolic dysfunction-associated steatotic liver disease: a cohort study Open
The findings suggest the importance of statin selection and highlight that gender-specific strategies may enhance treatment efficacy in the MASLD cohort.
View article: Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells Open
View article: Prolonged Intestinal Ethanol Absorption and Oxidative Stress: Revisiting the Gut–Liver Axis in Alcohol-Associated Disease
Prolonged Intestinal Ethanol Absorption and Oxidative Stress: Revisiting the Gut–Liver Axis in Alcohol-Associated Disease Open
Chronic alcohol consumption induces oxidative stress not only in the liver but also in the gastrointestinal tract, where prolonged intestinal ethanol absorption plays a pivotal and underrecognized role. This review reframes ethanol pharmac…
View article: Differential Ultrasonographic Diagnosis of Liver Masses
Differential Ultrasonographic Diagnosis of Liver Masses Open
Hepatic masses include a variety of benign and malignant lesions originating in the liver, and ultrasonography is one of the most basic and essential imaging tools for evaluating these lesions. This review comprehensively summarizes the ul…
View article: Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma
Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma Open
Background/Objectives: Metabolic-dysfunction-associated steatotic liver disease (MASLD) progresses from hepatic steatosis to hepatocellular carcinoma (HCC) as a result of systemic immunometabolic dysfunction. This review summarizes the key…
View article: Protective effects of Ginkgo biloba supplementation on clinical outcomes in metabolic dysfunction-associated steatotic liver disease
Protective effects of Ginkgo biloba supplementation on clinical outcomes in metabolic dysfunction-associated steatotic liver disease Open
Ginkgo biloba supplementation is associated with improved survival and reduced cardiovascular and renal risks in MASLD patients, particularly in high-risk subgroups. These findings highlight the potential of Ginkgo biloba as an adjunctive …
View article: A comprehensive analysis of the impact of smoking on adverse clinical outcomes of steatotic liver diseases
A comprehensive analysis of the impact of smoking on adverse clinical outcomes of steatotic liver diseases Open
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is an increasingly prevalent liver disorder. Objectives: This study investigated the effect of smo…
View article: Multivitamin supplementation and its impact in metabolic dysfunction-associated steatotic liver disease
Multivitamin supplementation and its impact in metabolic dysfunction-associated steatotic liver disease Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging global health concern with limited therapeutic options. Multivitamins, widely consumed dietary supplements, have been proposed to modulate oxidative stress and…
View article: Correspondence to editorial on “Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C”
Correspondence to editorial on “Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C” Open
View article: Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C
Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C Open
Background/Aims: Direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus. This study investigated whether metabolic dysfunction influences the likelihood of fibrosis regression after DAA treatment in patients with chronic h…
View article: Co‐administration of polyethylene glycol with binge ethanol reduces markers of intestinal and hepatic inflammation in <scp>C57BL</scp>/<scp>6J</scp> mice by diminishing ethanol absorption through the intestinal wall
Co‐administration of polyethylene glycol with binge ethanol reduces markers of intestinal and hepatic inflammation in <span>C57BL</span>/<span>6J</span> mice by diminishing ethanol absorption through the intestinal wall Open
Background Therapeutic options for managing intestinal and hepatic inflammation associated with alcohol consumption, a prevalent health problem worldwide, remain unavailable. This study examines the potential efficacy of polyethylene glyco…
View article: Eosinophilic Liver Abscess that Needs to be Differentiated from Malignant Tumor
Eosinophilic Liver Abscess that Needs to be Differentiated from Malignant Tumor Open
View article: Impact of Physical Activity on Overall Survival and Liver Cirrhosis Incidence in Steatotic Liver Disease: Insights from a Large Cohort Study Using Inverse Probability of Treatment Weighting
Impact of Physical Activity on Overall Survival and Liver Cirrhosis Incidence in Steatotic Liver Disease: Insights from a Large Cohort Study Using Inverse Probability of Treatment Weighting Open
Physical activity is a cornerstone of a healthy lifestyle, with benefits in managing chronic diseases. This study investigates the relationship between physical activity and liver-related outcomes with or without steatotic liver diseases, …
View article: Psyllium fiber improves hangovers and inflammatory liver injury by inhibiting intestinal drinking
Psyllium fiber improves hangovers and inflammatory liver injury by inhibiting intestinal drinking Open
Introduction: Excessive alcohol intake often results in hangovers and inflammatory liver damage, posing a significant health concern. Current treatment options for hangovers are still insufficient, highlighting the urgent need for new ther…
View article: Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment
Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment Open
Coffee consumption is globally widespread and has become a lifestyle habit. This study investigated coffee consumption and liver-related survival in a large cohort of 455,870 individuals with UK biobank, categorized into without steatosis,…
View article: Progression of Focal Nodular Hyperplasia in a 43-Year-Old Woman with Breast Cancer
Progression of Focal Nodular Hyperplasia in a 43-Year-Old Woman with Breast Cancer Open
Most liver masses that are incidentally found are benign lesions. Focal nodular hyperplasia (FNH) is the second most common benign solid hepatic mass that does not transform to malignancy. A 43-year-old woman who was diagnosed with breast …
View article: Clinical Impact of Fatty Pancreas and Its Correlation with Metabolic Disease: Focusing on the Cellular Mechanism and the Ultrasonographic Findings
Clinical Impact of Fatty Pancreas and Its Correlation with Metabolic Disease: Focusing on the Cellular Mechanism and the Ultrasonographic Findings Open
Fatty pancreas is commonly observed on abdominal ultrasonography. However, there is a lack of knowledge regarding the clinical significance and the severity of fatty pancreas. This review article summarized previous studies describing the …
View article: Defecation alleviates hangover by terminating intestinal drinking
Defecation alleviates hangover by terminating intestinal drinking Open
Introduction The concept of “intestinal drinking” in this study refers to the continued absorption of alcohol in the gastrointestinal tract until adequate defecation occurs. Material and methods A longitudinal observation of hangover sympt…
View article: Polyethylene Glycol Relieves Hangover by Reducing Alcohol Absorption through the Intestinal Wall
Polyethylene Glycol Relieves Hangover by Reducing Alcohol Absorption through the Intestinal Wall Open
Therapeutic options for hangover following alcohol consumption, a prevalent health problem worldwide, remain unavailable. This study investigated the effectiveness of polyethylene glycol (PEG) on hangovers using a mouse model. First, large…
View article: xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity Open
Obesity-mediated hypoxic stress underlies inflammation, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure. Here, we show…
View article: Comprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease
Comprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease Open
Introduction: The continuous rise in the prevalence of nonalcoholic fatty liver disease (NAFLD) is emerging as a global health issue. Although the protective effects of N-acetylcysteine (NAC), an antioxidant, against various diseases have …
View article: A Meta-Analysis of Preclinical Studies to Investigate the Effect of Panax ginseng on Alcohol-Associated Liver Disease
A Meta-Analysis of Preclinical Studies to Investigate the Effect of Panax ginseng on Alcohol-Associated Liver Disease Open
Alcohol-associated liver disease (ALD) has become a major global concern, but the development of effective drugs remains a challenge despite numerous preclinical and clinical pieces of research on the effects of natural compounds. To addre…
View article: Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease Open
View article: New insights in the pathogenesis of alcohol-related liver disease: The metabolic, immunologic, and neurologic pathways☆
New insights in the pathogenesis of alcohol-related liver disease: The metabolic, immunologic, and neurologic pathways☆ Open
Alcohol-related liver disease (ALD) became an important health issue worldwide. Following chronic alcohol consumption, the development of ALD might be caused by metabolic and immunologic factors, such as reactive oxygen species (ROS) and p…
View article: xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity Open
Obesity-mediated hypoxic stress underlies inflammatory responses, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure. We …
View article: Clinical impact of serum exosomal microRNA in liver fibrosis
Clinical impact of serum exosomal microRNA in liver fibrosis Open
Background/aim We investigated alterations in the expression of serum exosomal miRNAs with the progression of liver fibrosis and evaluated their clinical applicability as biomarkers. Methods This study prospectively enrolled 71 patients wh…
View article: Esophageal Involvement and Determinants of Perception of Esophageal Symptoms Among South Koreans With Systemic Sclerosis
Esophageal Involvement and Determinants of Perception of Esophageal Symptoms Among South Koreans With Systemic Sclerosis Open
Esophageal involvement among South Koreans with SSc was characterized by heterogeneous motility patterns, with a higher prevalence of normal motility and lower prevalence of erosive esophagitis. Reflux hypersensitivity or functional heartb…
View article: Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells
Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells Open