Explanipedia

Protocol for neuron tracing and analysis of dendritic structures from noisy microscopy images using Neuronalyzer Open

Yael Iosilevskii, Omer Yuval, Tom Shemesh, Benjamin Podbilewicz · 2024

Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis Open

Elle Koren, Alona Feldman, Marianna Yusupova, Avihay Kadosh, Egor Sedov , et al. · 2022

The presence of distinct stem cells that maintain the interfollicular epidermis is highly debated. Here, we report a population of keratinocytes, marked by Thy1, in the basal layer of the interfollicular epidermis. We find that epidermal c…

Directed cell invasion and differential adhesion drive tissue elongation and turning in C. elegans gonad morphogenesis Open

Priti Agarwal, Tom Shemesh, Ronen Zaidel‐Bar · 2022

Simulations of C. elegant gonad morphogenesis. Optimization and geometrical model implemented in Surface Evolver. Post and meta-processing implemented in Matlab Code. To use: Run gonad_A,fe to construct a simulation script filebased on ini…

A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules Open

Maria S. Tikhomirova, Avihay Kadosh, Aksel J. Saukko‐Paavola, Tom Shemesh, Robin W. Klemm · 2022

Significance The endoplasmic reticulum (ER) and the microtubule (MT) cytoskeleton form a coextensive, dynamic system that pervades eukaryotic cells. The shape of the ER is generated by a set of evolutionarily conserved membrane proteins th…

Data for: A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules Open

Maria S. Tikhomirova, Avihay Kadosh, Aksel J. Saukko‐Paavola, Tom Shemesh, Robin W. Klemm · 2022

This dataset has been furnished in support of the article "A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules" (PNAS, 2022).\n\n\n \n\n\nRaw image data for analysis of junction d…

Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans Open

Omer Yuval, Yael Iosilevskii, Anna Meledin, Benjamin Podbilewicz, Tom Shemesh · 2021

Complex dendritic trees are a distinctive feature of neurons. Alterations to dendritic morphology are associated with developmental, behavioral and neurodegenerative changes. The highly-arborized PVD neuron of C . elegans serves as a model…

Mechanism of membrane-curvature generation by ER-tubule shaping proteins Open

Ning Wang, Lindsay Clark, Yuan Gao, Michael M. Kozlov, Tom Shemesh , et al. · 2021

The tilted helix model of dynamin oligomers Open

Avihay Kadosh, Adai Colom, Ben Yellin, Aurélien Roux, Tom Shemesh · 2019

Significance Hydrolysis of GTP leads to remodeling of dynamin helical collars and severing of the underlying membrane neck—a critical step in vesicle endocytosis. We use mathematical modeling to explore the mechanisms that regulate oligome…

Cytoplasmic self-organization established by internal lipid membranes in the interplay with either actin or microtubules Open

Sindy K. Y. Tang, Malte Renz, Tom Shemesh, Meghan Driscoll, Jennifer Lippincott‐Schwartz · 2018

Cells harbor an intrinsic organization of their components. Specific protein structures, as the centrosome, have been described master regulators of cell organization. In the absence of these key elements, however, cytoplasmic selforganiza…

Buckle up: Membrane tension drives lamellipodial network compression and adhesion deposition Open

Kinneret Keren, Tom Shemesh · 2017

Whether to spread on a surface or to crawl, cells must apply traction forces to the underlying substrate via adhesion complexes. In this issue, Pontes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201611117) shed new light on how…

Physical Model for Stabilization and Repair of Trans-endothelial Apertures Open

É. G. Fedorov, Tom Shemesh · 2017

A Model for Shaping Membrane Sheets by Protein Scaffolds Open

Yonatan Schweitzer, Tom Shemesh, Michael M. Kozlov · 2015

Cis and trans interactions between atlastin molecules during membrane fusion Open

Tina Y. Liu, Xin Bian, Fabian B. Romano, Tom Shemesh, Tom A. Rapoport , et al. · 2015

Significance The membrane-anchored GTPase atlastin (ATL) mediates the fusion of endoplasmic reticulum membranes into a network of tubules and sheets, but the mechanism of ATL function is still poorly understood. Here we show that vesicle f…

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