Tom Siegl
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View article: Maternal <i>IGHG</i> locus duplications impair infants’ passive immunity
Maternal <i>IGHG</i> locus duplications impair infants’ passive immunity Open
Infants depend on passive immunity to safeguard them against infections during the first months of life. Maternal immunoglobulin G (IgG) antibodies are actively transported across the placenta and confer this protection. In this study, we …
View article: SubROC: AUC-Based Discovery of Exceptional Subgroup Performance for Binary Classifiers
SubROC: AUC-Based Discovery of Exceptional Subgroup Performance for Binary Classifiers Open
Machine learning (ML) is increasingly employed in real-world applications like medicine or economics, thus, potentially affecting large populations. However, ML models often do not perform homogeneously, leading to underperformance or, con…
View article: Informed, but Not Always Improved: Challenging the Benefit of Background Knowledge in GNNs
Informed, but Not Always Improved: Challenging the Benefit of Background Knowledge in GNNs Open
In complex and low-data domains such as biomedical research, incorporating background knowledge (BK) graphs, such as protein-protein interaction (PPI) networks, into graph-based machine learning pipelines is a promising research direction.…