Tom Stiff
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View article: <i>Ceudovitox:</i> a novel pseudotyped-virus screening platform to identify cell entry factors for high consequence infections
<i>Ceudovitox:</i> a novel pseudotyped-virus screening platform to identify cell entry factors for high consequence infections Open
Development of scalable and highly adaptable platforms to characterise high consequence infections are essential for limiting the impact of future viruses with pandemic potential. As part of this, an understanding of the virus-host interac…
View article: Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage
Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage Open
View article: CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth
CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth Open
Our study employs pooled CRISPR screens, integrating 2D and 3D culture models, to identify miRNAs critical in Breast Cancer (BC) tumoursphere formation. These screens combine with RNA-seq experiments allowing identification of miRNA signat…
View article: CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth
CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth Open
Breast cancer (BC) is a heterogeneous malignancy with distinct molecular subtypes and clinical characteristics. Tumour-initiating cells (TICs) are a small subset of cancer cells that are responsible for tumour initiation and progression. O…
View article: Data from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Data from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation Open
H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein k…
View article: Data from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Data from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation Open
H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein k…
View article: Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation Open
Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
View article: Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation Open
Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
View article: Prophase-Specific Perinuclear Actin Coordinates Centrosome Separation and Positioning to Ensure Accurate Chromosome Segregation
Prophase-Specific Perinuclear Actin Coordinates Centrosome Separation and Positioning to Ensure Accurate Chromosome Segregation Open
View article: Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis
Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis Open
To ensure proper segregation during mitosis, chromosomes must be efficiently captured by spindle microtubules and subsequently aligned on the mitotic spindle. The efficacy of chromosome interaction with the spindle can be influenced by how…
View article: Author response: Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis
Author response: Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract To ensure proper segregation during mitosi…
View article: Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis
Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis Open
To ensure proper segregation during mitosis, chromosomes must be efficiently captured by kinetochore microtubules and subsequently aligned on the mitotic spindle. The efficacy of chromosome capture by the mitotic spindle can be influenced …
View article: ATR promotes cilia signalling: links to developmental impacts
ATR promotes cilia signalling: links to developmental impacts Open
Mutations in ATR(ataxia telangiectasia and RAD3-related) cause Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder. Hitherto, the clinical manifestation of ATR deficiency has been attributed to its canonical role in DNA …