Tom Wei‐Wu Chen
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View article: Aristolochic acid and alternative lengthening of telomeres mechanisms underlie liver angiosarcoma pathogenesis
Aristolochic acid and alternative lengthening of telomeres mechanisms underlie liver angiosarcoma pathogenesis Open
Background Our previous epidemiological study revealed a significantly higher incidence of liver angiosarcoma in Asian patients than that in their European counterparts. Elucidating the etiology and hallmarks of this aggressive malignancy …
View article: Carcinomas exhibiting epithelial–mesenchymal transition manifest an M2 macrophage-enriched tumor immune microenvironment
Carcinomas exhibiting epithelial–mesenchymal transition manifest an M2 macrophage-enriched tumor immune microenvironment Open
Background Epithelial–mesenchymal transition (EMT) is linked to an immunosuppressive tumor microenvironment (TME). However, direct comparisons of the TME in paired tumor regions with and without EMT in primary tumors—essential for elucidat…
View article: Correspondence: Prognostic significance of positive surgical margins for scalp angiosarcoma
Correspondence: Prognostic significance of positive surgical margins for scalp angiosarcoma Open
View article: Maintenance therapy—a potential strategy to prolong the survival of advanced soft tissue sarcoma patients
Maintenance therapy—a potential strategy to prolong the survival of advanced soft tissue sarcoma patients Open
Anthracycline-based chemotherapy remains the cornerstone of first-line systemic treatment for most subtypes of advanced soft tissue sarcoma (STS). However, cumulative cardiotoxicity and a decline in quality of life limit the treatment dura…
View article: A Phase 3 Study of the Efficacy and Safety of Pexidartinib in East Asian Patients with Tenosynovial Giant Cell Tumor
A Phase 3 Study of the Efficacy and Safety of Pexidartinib in East Asian Patients with Tenosynovial Giant Cell Tumor Open
ClinicalTrials.gov identifier NCT04488822.
View article: Acyl post-translational modification of proteins by metabolites in cancer cells
Acyl post-translational modification of proteins by metabolites in cancer cells Open
View article: Tumor Immunotherapy Targeting B7-H3: From Mechanisms to Clinical Applications
Tumor Immunotherapy Targeting B7-H3: From Mechanisms to Clinical Applications Open
B7-H3 (CD276) is an immune checkpoint from the B7 family of molecules and is abnormally expressed in tumor cells as a co-inhibitory molecule to promote tumor progression. Within the tumor microenvironment (TME), B7-H3 promotes tumor progre…
View article: Response to comment on “Comparative analysis of preoperative chemotherapy versus postoperative chemotherapy in advanced soft tissue sarcoma”
Response to comment on “Comparative analysis of preoperative chemotherapy versus postoperative chemotherapy in advanced soft tissue sarcoma” Open
View article: New Di/Trinormonoterpenoid Glucosides as Novel Cyclooxygenase-2 Inhibitors from Periplocae Cortex
New Di/Trinormonoterpenoid Glucosides as Novel Cyclooxygenase-2 Inhibitors from Periplocae Cortex Open
View article: Precise Molecular Discrimination of Renal Cell Carcinoma Tissues Based on Lipidomics Using Tip-Contact Sampling/Ionization Mass Spectrometry
Precise Molecular Discrimination of Renal Cell Carcinoma Tissues Based on Lipidomics Using Tip-Contact Sampling/Ionization Mass Spectrometry Open
View article: Hormone therapy enhances anti-PD1 efficacy in premenopausal estrogen receptor-positive and HER2-negative advanced breast cancer
Hormone therapy enhances anti-PD1 efficacy in premenopausal estrogen receptor-positive and HER2-negative advanced breast cancer Open
View article: Evaluation of the association between bevacizumab concentration and clinical outcomes in patients with breast cancer brain metastasis
Evaluation of the association between bevacizumab concentration and clinical outcomes in patients with breast cancer brain metastasis Open
Bevacizumab is widely used in various clinical indications, but investigations into its optimal dosage for treating CNS metastases remain limited. The BEEP regimen, comprising bevacizumab, etoposide, and cisplatin, has recently demonstrate…
View article: Denosumab combined with immunotherapy, radiotherapy, and granulocyte-macrophage colony-stimulating factor for the treatment of metastatic nasopharyngeal carcinoma: A case report
Denosumab combined with immunotherapy, radiotherapy, and granulocyte-macrophage colony-stimulating factor for the treatment of metastatic nasopharyngeal carcinoma: A case report Open
BACKGROUND Bone is a major site of metastasis in nasopharyngeal carcinoma (NPC). Recently, nuclear factor kappa-beta ligand (RANKL) inhibitors have garnered attention for their ability to inhibit osteoclast formation and bone resorption, a…
View article: Characteristics and transcriptional regulators of spontaneous epithelial–mesenchymal transition in genetically unperturbed patient-derived non-spindled breast carcinoma
Characteristics and transcriptional regulators of spontaneous epithelial–mesenchymal transition in genetically unperturbed patient-derived non-spindled breast carcinoma Open
Background Although tumor cells undergoing epithelial–mesenchymal transition (EMT) typically exhibit spindle morphology in experimental models, such histomorphological evidence of EMT has predominantly been observed in rare primary spindle…
View article: Concurrent epirubicin and trastuzumab use increases complete pathological response rate without additional cardiotoxicity in patients with human epidermal growth factor receptor 2‐positive early breast cancer: A meta‐regression analysis
Concurrent epirubicin and trastuzumab use increases complete pathological response rate without additional cardiotoxicity in patients with human epidermal growth factor receptor 2‐positive early breast cancer: A meta‐regression analysis Open
Background Due to cardiotoxicity concerns, the concurrent use of epirubicin and trastuzumab has not been fully studied. This study aimed to examine the cardiotoxicity and pathological complete response (pCR) rate associated with the concur…
View article: Proteomic features of soft tissue tumours in adolescents and young adults
Proteomic features of soft tissue tumours in adolescents and young adults Open
View article: Characteristics and transcriptional regulators of spontaneous epithelial–mesenchymal transition in real-world genetically unperturbed non-spindle breast carcinoma
Characteristics and transcriptional regulators of spontaneous epithelial–mesenchymal transition in real-world genetically unperturbed non-spindle breast carcinoma Open
Background Although epithelial–mesenchymal transition (EMT) has been well-characterized in experimental models, convincing histopathological evidence of EMT in primary carcinomas has only been obtained for rare spindle carcinomas. The exis…
View article: A case of primary pleural epithelioid hemangioendothelioma achieving stable disease with paclitaxel treatment: A case report and literature review
A case of primary pleural epithelioid hemangioendothelioma achieving stable disease with paclitaxel treatment: A case report and literature review Open
Epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm with a clinical behaviour that falls between a benign hemangioma and a high‐grade angiosarcoma. Pleural EHE is exceptionally rare, and its prognosis is grim, with most pati…
View article: Sequential multimodal treatments with chemotherapy and surgery for advanced soft tissue sarcoma may be associated with better survival than chemotherapy
Sequential multimodal treatments with chemotherapy and surgery for advanced soft tissue sarcoma may be associated with better survival than chemotherapy Open
Surgery may be more beneficial for the patients who receive chemotherapy. Our results support evaluation of sequential multimodal treatments strategy including surgery and chemotherapy in patients with advanced STS.
View article: Expert Consensus on Molecular Tumor Boards in Taiwan: Joint Position Paper by the Taiwan Oncology Society and the Taiwan Society of Pathology
Expert Consensus on Molecular Tumor Boards in Taiwan: Joint Position Paper by the Taiwan Oncology Society and the Taiwan Society of Pathology Open
Background: The Taiwan Oncology Society (TOS) and the Taiwan Society of Pathology (TSP) have collaborated to present a joint position paper on the molecular tumor boards (MTBs) within the medical institutions of Taiwan. Materials and Metho…
View article: Delay of Surgery for Spinal Metastasis due to the COVID-19 Outbreak Affected Patient Outcomes
Delay of Surgery for Spinal Metastasis due to the COVID-19 Outbreak Affected Patient Outcomes Open
Objective: The present study is to analyze the effects of the coronavirus disease 2019 (COVID 2019) outbreak and the subsequent lockdown on the outcomes of spinal metastasis patients.Methods: The study was a retrospective analysis of data …
View article: Whole-Brain Radiotherapy Alone vs Preceded by Bevacizumab, Etoposide, and Cisplatin for Untreated Brain Metastases From Breast Cancer
Whole-Brain Radiotherapy Alone vs Preceded by Bevacizumab, Etoposide, and Cisplatin for Untreated Brain Metastases From Breast Cancer Open
Importance The incidence of brain metastasis is increasing in patients with metastatic breast cancer. Treatments to extend the control of brain metastasis are urgently required. Objective To investigate whether the addition of an induction…
View article: Proteomic Features of Adolescents and Young Adults with Soft Tissue Tumours
Proteomic Features of Adolescents and Young Adults with Soft Tissue Tumours Open
Adolescents and young adult (AYA) patients with soft tissue tumours (STT) including sarcomas are an underserved group with disparities in treatment outcomes. To define the molecular features between AYA and older adult (OA) patients, we an…
View article: C <sub>21</sub> steroidal glycosides from the root bark of <i>Periploca sepium</i> and their NO production inhibitory and cytotoxic activity
C <sub>21</sub> steroidal glycosides from the root bark of <i>Periploca sepium</i> and their NO production inhibitory and cytotoxic activity Open
A series of C21 steroidal glycosides were isolated from the root bark of Periploca sepium, including a new compound, perisepiumoside A1 (1), and six known compounds (2-7). Their structures were elucidated by…
View article: Disparity in survival benefits of pembrolizumab between Asian and <scp>non‐Asian</scp> patients with advanced cancers: A systematic review and <scp>meta‐regression</scp> analysis
Disparity in survival benefits of pembrolizumab between Asian and <span>non‐Asian</span> patients with advanced cancers: A systematic review and <span>meta‐regression</span> analysis Open
Background Immune checkpoint inhibitors have revolutionized the treatment of malignancies. However, disproportionate enrollment among races and ethnicities places the generalizability of global trial results in doubt. Methods In this syste…
View article: The proteomic landscape of soft tissue sarcomas
The proteomic landscape of soft tissue sarcomas Open
View article: Plasma cell-free tumor DNA, PIK3CA and TP53 mutations predicted inferior endocrine-based treatment outcome in endocrine receptor-positive metastatic breast cancer
Plasma cell-free tumor DNA, PIK3CA and TP53 mutations predicted inferior endocrine-based treatment outcome in endocrine receptor-positive metastatic breast cancer Open
Purpose How to factor both tumor burden and oncogenic genomic mutations as variables to predict the outcome of endocrine-based therapy (ET) in ER-positive/HER2-negative metastatic breast cancer patients (MBC) remains to be explored. Method…
View article: Supplementary Figure 1 from A Single-Arm Phase Ib/II Study of Lenvatinib plus Eribulin in Advanced Liposarcoma and Leiomyosarcoma
Supplementary Figure 1 from A Single-Arm Phase Ib/II Study of Lenvatinib plus Eribulin in Advanced Liposarcoma and Leiomyosarcoma Open
CONSORT diagram
View article: Supplementary Appendix from A Single-Arm Phase Ib/II Study of Lenvatinib plus Eribulin in Advanced Liposarcoma and Leiomyosarcoma
Supplementary Appendix from A Single-Arm Phase Ib/II Study of Lenvatinib plus Eribulin in Advanced Liposarcoma and Leiomyosarcoma Open
Decision on Final Phase II dose; Guidelines combination dose level adjustments in the phase Ib phase; Schema for dose adjustments if more than 2 patients have DLT; Definitions of DLT
View article: Supplementary Table 1 from A Single-Arm Phase Ib/II Study of Lenvatinib plus Eribulin in Advanced Liposarcoma and Leiomyosarcoma
Supplementary Table 1 from A Single-Arm Phase Ib/II Study of Lenvatinib plus Eribulin in Advanced Liposarcoma and Leiomyosarcoma Open
Supplementary Table 1a. Differentially expressed genes between Post-treatment vs Pre-treatment; Supplementary Table 1b. Differentially expressed genes between Responders vs Nonresponders; Supplementary Table 1c. Differentially expressed ge…