Tom Wilsgaard
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View article: Social integration and mortality across the life course: findings from the Tromsø study
Social integration and mortality across the life course: findings from the Tromsø study Open
Our study consolidates evidence on the relationship between social integration and mortality risk, especially in mid-adulthood, and suggests some potential underlying pathways. To reduce mortality risk inequalities, we encourage structural…
View article: Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study—the Tromsø Study
Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study—the Tromsø Study Open
OBJECTIVES: The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. DESIGN AND SETTING: A populations-based c…
View article: Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes
Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes Open
We assessed temporal changes of PFAS and associations with T2DM over a period of 30 years in a nested case–control study with repeated measurements. Logistic regression was used to assess associations between 11 PFAS and T2DM at five time-…
View article: Per- and polyfluoroalkyl substances and associated proteomic biomarker patterns of immuno-suppression and cell-proliferation in an adolescent population from Northern Norway: The Fit Futures Study
Per- and polyfluoroalkyl substances and associated proteomic biomarker patterns of immuno-suppression and cell-proliferation in an adolescent population from Northern Norway: The Fit Futures Study Open
Exposure to PFOS, PFUnDA, and PFHpS were associated with biomarkers related to immunosuppression, while exposure to PFOA was associated with biomarkers related to carcinogenesis.
View article: Associations of educational level with ECG-derived cardiovascular ageing in a population-based cohort: a mediation analysis from the Tromsø Study
Associations of educational level with ECG-derived cardiovascular ageing in a population-based cohort: a mediation analysis from the Tromsø Study Open
Objective To assess the association between educational level and cardiovascular age acceleration metric derived from ECG, and to determine whether this association is mediated by established cardiovascular disease (CVD) risk factors. Desi…
View article: A New Biomarker of Aging Derived From Electrocardiograms Improves Risk Prediction of Incident Cardiovascular Disease
A New Biomarker of Aging Derived From Electrocardiograms Improves Risk Prediction of Incident Cardiovascular Disease Open
Incorporating δ-age into primary prevention risk prediction models significantly improved performance beyond traditional cardiovascular risk factors for the combined outcome and separately for MI and stroke.
View article: Socioeconomic position, mediators, and risk of atrial fibrillation in a general, adult population
Socioeconomic position, mediators, and risk of atrial fibrillation in a general, adult population Open
Background Socioeconomic position (SEP) is associated with inequalities in health worldwide, and with several cardiovascular diseases and risk factors. The association between SEP and incident atrial fibrillation (AF), and the potential ca…
View article: Educational level, mediators, and risk of atrial fibrillation by sex in The Tromsø Study 1994–2016
Educational level, mediators, and risk of atrial fibrillation by sex in The Tromsø Study 1994–2016 Open
Aims To study the association between socioeconomic position (SEP), indicated by educational level, and incident atrial fibrillation (AF), and the role of lifestyle and cardiovascular risk factors as potential mediators in the causal pathw…
View article: Occasional smoking is a risk factor for myocardial infarction in the population-based Tromsø Study, 2001–21
Occasional smoking is a risk factor for myocardial infarction in the population-based Tromsø Study, 2001–21 Open
Aims While the association between daily smoking and myocardial infarction (MI) risk is well-established, little is known concerning the relationship between occasional smoking and MI risk. In this Norwegian study, we aimed to investigate …
View article: Longitudinal and concurrent C-reactive protein and diet associations with cognitive function in the population-based Tromsø study
Longitudinal and concurrent C-reactive protein and diet associations with cognitive function in the population-based Tromsø study Open
Background Immune dysregulation has been implicated in Alzheimer's disease; however, precise mechanisms and timing have not been established. Objective To investigate the concurrent and longitudinal associations of serum C-reactive protein…
View article: Heart Failure in Atrial Fibrillation Subtypes in Women and Men in the Tromsø Study
Heart Failure in Atrial Fibrillation Subtypes in Women and Men in the Tromsø Study Open
All AF subtypes were associated with increased risk of HF. Smoking was a shared risk factor, while diastolic blood pressure and hypertension were specific to women, and underweight, obesity, and low alcohol intake were specific to men. Sub…
View article: Long-term pulse pressure trajectories and risk of incident atrial fibrillation: the Tromsø Study
Long-term pulse pressure trajectories and risk of incident atrial fibrillation: the Tromsø Study Open
Background and Aims Sex-based differences in the association of long-term trends in pulse pressure with future risk of atrial fibrillation (AF) have been explored using data from the population-based Tromsø Study 1986–2016. Methods Women (…
View article: Risk prediction in carotid stenosis with time dependency of high-impact variables and multiple endpoint analysis
Risk prediction in carotid stenosis with time dependency of high-impact variables and multiple endpoint analysis Open
Background: Electronic patient records represent a potential data source for the future, as digital free text extraction by artificial intelligence is coming closer to safe options for handling of confidential information. Big data from pa…
View article: Tracing Obesity From Parents to Adult Offspring: The Tromsø Study 1994–2016
Tracing Obesity From Parents to Adult Offspring: The Tromsø Study 1994–2016 Open
Objective The combination of genetic and environmental contributors to obesity can be studied through intergenerational associations as previously shown in studies of parents and their children and adolescents. Few studies have investigate…
View article: Longitudinal cholesterol trends across socioeconomic groups in Norway: the influence of lipid-lowering drugs in the population-based Tromsø Study 1994–2016
Longitudinal cholesterol trends across socioeconomic groups in Norway: the influence of lipid-lowering drugs in the population-based Tromsø Study 1994–2016 Open
Objectives There is limited evidence regarding the impact of lipid-lowering drugs (LLDs) on the socioeconomic gradient in a longitudinal perspective. The study investigates the longitudinal socioeconomic gradient in total cholesterol level…
View article: Associations between body height and cardiovascular risk factors in women and men: a population-based longitudinal study based on The Tromsø Study 1979–2016
Associations between body height and cardiovascular risk factors in women and men: a population-based longitudinal study based on The Tromsø Study 1979–2016 Open
Objectives Investigate associations between body height and cardiovascular disease risk factors at several time points in women and men across educational levels in Norway. Design Population-based longitudinal study. Setting The Tromsø Stu…
View article: Exploring interaction between genetically predicted body mass index and serum 25-hydroxyvitamin D levels on the odds for psoriasis in UK Biobank and the HUNT Study: A factorial Mendelian randomisation study
Exploring interaction between genetically predicted body mass index and serum 25-hydroxyvitamin D levels on the odds for psoriasis in UK Biobank and the HUNT Study: A factorial Mendelian randomisation study Open
Background Mendelian randomisation (MR) studies show that higher body mass index (BMI) and lower 25-hydroxyvitamin D (25[OH]D) increase psoriasis risk. The combined effect of these factors has not been explored using factorial MR. Methods …
View article: Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study
Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study Open
Background: Studies of excess weight and weight changes throughout adult life for prostate cancer (PCa) risk and prognosis have shown inconsistent results. Methods: In a population-based cohort, the Prostate Cancer Study throughout life (P…
View article: Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromsø Study 2015–2016
Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromsø Study 2015–2016 Open
Objective We aimed to examine associations between educational level, serving as an indicator of socioeconomic position, and prevalence of WHO-established leading behavioural and biological risk factors for non-communicable diseases (NCDs)…
View article: Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study Open
The combination of obesity and ischemic stroke did not yield an excess risk of VTE. Our findings suggest that obese subjects with ischemic stroke do not have a more than additive risk of VTE.
View article: The association between serum 25-hydroxyvitamin D levels and psoriasis in a large population-based cohort: a cross-sectional analysis of The Tromsø Study 2015–16
The association between serum 25-hydroxyvitamin D levels and psoriasis in a large population-based cohort: a cross-sectional analysis of The Tromsø Study 2015–16 Open
Background Case–control studies indicate an association between lower serum 25-hydroxyvitamin D [25(OH)D] levels and psoriasis. Data from larger population-based cohorts including mild cases are sparse. Objectives To investigate the associ…
View article: Lifestyle factors as mediators of area-level socioeconomic differentials in mental health and cognitive function: the Tromsø Study
Lifestyle factors as mediators of area-level socioeconomic differentials in mental health and cognitive function: the Tromsø Study Open
Introduction Low socioeconomic status (SES) is associated with poor mental health and cognitive function. Individual-level SES and area-level SES (ASES) may affect mental health and cognitive function through lifestyle. We aimed to quantif…
View article: Educational patterning in biological health seven years apart: Findings from the Tromsø Study
Educational patterning in biological health seven years apart: Findings from the Tromsø Study Open
This longitudinal analysis highlights that participants with lower education had their biological health deteriorated to a greater extent over time compared to people with higher education. Our findings provide added evidence of the biolog…
View article: Occupational physical activity and risk of mortality in women and men: the Tromsø Study 1986–2021
Occupational physical activity and risk of mortality in women and men: the Tromsø Study 1986–2021 Open
Objective Associations between occupational physical activity (OPA) and mortality risks are inconclusive. We aimed to examine associations between (1) OPA separately and (2) jointly with leisure time physical activity (LTPA), and risk of a…