Abstract Background and Aims Sex-based differences in the association of long-term trends in pulse pressure with future risk of atrial fibrillation (AF) have been explored using data from the population-based Tromsø Study 1986–2016. Methods Women (n = 8331) and men (n = 7638) aged ≥20 years who attended at least two of the three Tromsø Study surveys conducted between 1986 and 2001 (the exposure period) were followed up for incident AF throughout 2016 (the follow-up period). Pulse pressure ≥60 mmHg was considered e…

Abstract Aims While the association between daily smoking and myocardial infarction (MI) risk is well-established, little is known concerning the relationship between occasional smoking and MI risk. In this Norwegian study, we aimed to investigate the risk of first-time MI among occasional smokers over a 20-year follow-up period. Methods and results In this prospective cohort study, data on smoking habits and relevant risk factors were collected from 15 617 participants enrolled in the fifth and/or sixth survey of…

Background Immune dysregulation has been implicated in Alzheimer's disease; however, precise mechanisms and timing have not been established. Objective To investigate the concurrent and longitudinal associations of serum C-reactive protein (CRP) and dietary inflammatory index (DII) with cognitive decline as observed in Alzheimer's disease. Methods The study was based on 7613 individuals who participated in Tromsø6 (2007–2008) and Tromsø7 (2015–2016). We analyzed the relationship between CRP levels, DII, and cognit…

Incorporating δ-age into primary prevention risk prediction models significantly improved performance beyond traditional cardiovascular risk factors for the combined outcome and separately for MI and stroke.

All AF subtypes were associated with increased risk of HF. Smoking was a shared risk factor, while diastolic blood pressure and hypertension were specific to women, and underweight, obesity, and low alcohol intake were specific to men. Subsequent HF increased mortality risk in all.