Explanipedia

High-Throughput Site-Specific N-Glycosylation Profiling of Human Fibrinogen in Atrial Fibrillation Open

Dinko Šoić, Domagoj Kifer, Janko Szavits-Nossan, Aleksandar Blivajs, Lovorka Đerek , et al. · 2025

Fibrinogen is a major plasma glycoprotein involved in blood coagulation and inflammatory responses. Alterations in its glycosylation have been implicated in various pathological conditions; yet, its site-specific N-glycosylation profile re…

High-Throughput Site-Specific N-Glycosylation Profiling of Human Fibrinogen in Atrial Fibrillation Open

Dinko Šoić, Domagoj Kifer, Janko Szavits-Nossan, Aleksandar Blivajs, Lovorka Đerek , et al. · 2025

Fibrinogen is a major plasma glycoprotein involved in blood coagulation and inflammatory responses. Alterations in its glycosylation have been implicated in various pathological conditions, yet its site-specific N-glycosylation profile rem…

Influence of Desialylation on the Drug Binding Affinity of Human Alpha-1-Acid Glycoprotein Assessed by Microscale Thermophoresis Open

Tino Šeba, Robert Kerep, Tin Weitner, Dinko Šoić, Toma Keser , et al. · 2024

Human serum alpha-1-acid glycoprotein (AAG) is an acute-phase plasma protein involved in the binding and transport of many drugs, especially basic and lipophilic substances. The sialic acid groups that terminate the N-glycan chains of AAG …

Mapping of the gene network that regulates glycan clock of ageing Open

Azra Frkatović-Hodžić, Anika Mijakovac, Karlo Miškec, Arina Nostaeva, Sodbo Sharapov , et al. · 2023

Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide as…

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Open

Vedrana Vičić Bočkor, Nika Foglar, Goran Josipović, Marija Klasić, Ana Vujić , et al. · 2023

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liver, creating a regulatory transcriptiona…

Human complement component C3 N-glycome changes in type 1 diabetes complications Open

Dinko Šoić, Jerko Štambuk, Marko Tijardović, Toma Keser, Gordan Lauc , et al. · 2023

Aim Changes in N-glycosylation have been described in numerous diseases and are being considered as biomarkers of ongoing pathological condition. Previous studies demonstrated the interrelation of N-glycosylation and type 1 diabetes (T1D),…

Potential Clinically Relevant Effects of Sialylation on Human Serum AAG-Drug Interactions Assessed by Isothermal Titration Calorimetry: Insight into Pharmacoglycomics? Open

Robert Kerep, Tino Šeba, Valentina Borko, Tin Weitner, Toma Keser , et al. · 2023

Human serum alpha-1 acid glycoprotein is an acute-phase plasma protein involved in the binding and transport of many drugs, especially basic and lipophilic substances. It has been reported that the sialic acid groups that terminate the N–g…

Mapping of the gene network that regulates glycan clock of ageing Open

Azra Frkatović-Hodžić, Karlo Miškec, Anika Mijakovac, Arina Nostaeva, Sodbo Sharapov , et al. · 2023

Glycans are an essential structural component of Immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide as…

Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes Open

Najda Rudman, Simranjeet Kaur, Vesna Simunović, Domagoj Kifer, Dinko Šoić , et al. · 2023

In a pursuit of optimal glycan fluorescent label for negative MS mode for high-throughput N-glycan analysis Open

Dinko Šoić, Zvonimir Mlinarić, Gordan Lauc, Olga Gornik, Mislav Novokmet , et al. · 2022

Over the past few decades, essential role of glycosylation in protein functioning has become widely recognized, rapidly advancing glycan analysis techniques. Because free glycan’s lack chromophore or fluorophore properties, and do not ioni…

High-Throughput Human Complement C3 N-Glycoprofiling Identifies Markers of Early Onset Type 1 Diabetes Mellitus in Children Open

Dinko Šoić, Toma Keser, Jerko Štambuk, Domagoj Kifer, Flemming Pociot , et al. · 2022

Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches Open

Ana Cvetko, Massimo Mangino, Marko Tijardović, Domagoj Kifer, Mario Falchi , et al. · 2021

Introduction Prediction of type 2 diabetes mellitus (T2DM) and its preceding factors, such as insulin resistance (IR), is of great importance as it may allow delay or prevention of onset of the disease. Plasma protein N-glycome has emerged…

High-Throughput and Site-Specific N-Glycosylation Analysis of Human Alpha-1-Acid Glycoprotein Offers a Great Potential for New Biomarker Discovery Open

Toma Keser, Marko Tijardović, Ivan Gornik, Edita Lukić, Gordan Lauc , et al. · 2020

Alpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists of 45% carbohydrates that are present in the form of f…

A strategy to incorporate prior knowledge into correlation network cutoff selection Open

Elisa Benedetti, Maja Pučić‐Baković, Toma Keser, Nathalie Gerstner, Mustafa Büyüközkan , et al. · 2020

Global variability of the human IgG glycome Open

Jerko Štambuk, Natali Nakić, Frano Vučković, Maja Pučić‐Baković, Genadij Razdorov , et al. · 2020

Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with…

Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference Open

Elisa Benedetti, Nathalie Gerstner, Maja Pučić‐Baković, Toma Keser, Karli R. Reiding , et al. · 2020

Glycomics measurements, like all other high-throughput technologies, are subject to technical variation due to fluctuations in the experimental conditions. The removal of this non-biological signal from the data is referred to as normaliza…

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Open

Lucija Klarić, Yakov A. Tsepilov, Chloë M. Stanton, Massimo Mangino, Timo Tõnis Sikka , et al. · 2020

Variation in key transcription factors and glycogenes modifies IgG glycosylation and has an influence on inflammatory diseases.

Supplementary Data for the paper: A strategy to incorporate prior knowledge into correlation network cutoff selection Open

Elisa Benedetti, Maja Pučić‐Baković, Toma Keser, Nathalie Gerstner, Mustafa Büyüközkan , et al. · 2020

We include here several supplementary data files that will help replicate the transcriptomics results reported in our paper using the code uploaded to https://github.com/krumsieklab/CutoffOpt.- STRING adjacency- CORUM adjacency- Reactome p…

Supplementary data for the paper: Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference Open

Elisa Benedetti, Nathalie Gerstner, Maja Pučić‐Baković, Toma Keser, Karli R. Reiding , et al. · 2020

The dataset includes unprocessed IgG N-glycan data measured in five cohorts: Korcula2013, Korcula2010, Split, Vis (LC-ESI-MS), and the controls from a colorectal cancer study (UHPLC-FLD).

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Open

Lucija Klarić, Yakov A. Tsepilov, Chloë M. Stanton, Massimo Mangino, Timo Tõnis Sikka , et al. · 2020

Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood abou…

Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile Open

Marko Tijardović, Domagoj Marijančević, Daniel Bok, Domagoj Kifer, Gordan Lauc , et al. · 2019

Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understand…

Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage Open

Toma Keser, Mario Kofler, Mariella Katzmayr, Alois Josef Schiefecker, Verena Rass , et al. · 2019

Systematic evaluation of normalization methods for glycomics data based on performance of network inference Open

Elisa Benedetti, Nathalie Gerstner, Maja Pučić‐Baković, Toma Keser, Karli R. Reiding , et al. · 2019

Glycomics measurements, like all other high-throughput technologies, are subject to technical variation due to fluctuations in the experimental conditions. The removal of this non-biological signal from the data is referred to as normaliza…

A strategy to incorporate prior knowledge into correlation network cutoff selection Open

Elisa Benedetti, Maja Pučić‐Baković, Toma Keser, Nathalie Gerstner, Mustafa Büyüközkan , et al. · 2019

Correlation networks are commonly used to statistically extract biological interactions between omics markers. Network edge selection is typically based on the significance of the underlying correlation coefficients. A statistical cutoff, …

Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system Open

Goran Josipović, Vanja Tadić, Marija Klasić, Vladimir Zanki, Ivona Bečeheli , et al. · 2019

Establishing causal relationship between epigenetic marks and gene transcription requires molecular tools, which can precisely modify specific genomic regions. Here, we present a modular and extensible CRISPR/dCas9-based toolbox for epigen…

Global variability of the human IgG glycome Open

Jerko Štambuk, Natali Nakić, Frano Vučković, Maja Pučić‐Baković, Genadij Razdorov , et al. · 2019

Immunoglobulin G (IgG) is the most abundant serum antibody and is a key determinant of the humoral immune response. Its structural characteristics and effector functions are modulated through the attachment of various sugar moieties called…

N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease Open

Tamara Pavić, Dario Dilber, Domagoj Kifer, Najda Selak, Toma Keser , et al. · 2018

Comparison of 2-Aminobenzamide, Procainamide and RapiFluor-MS as Derivatizing Agents for High-Throughput HILIC-UPLC-FLR-MS N-glycan Analysis Open

Toma Keser, Tamara Pavić, Gordan Lauc, Olga Gornik · 2018

Rising awareness of the universal importance of protein N-glycosylation governs the development of further advances in N-glycan analysis. Nowadays it is well known that correct glycosylation is essential for proper protein function, which …

Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors Open

Zrinka Rajić, Maja Beus, Hana Michnová, Josipa Vlainić, Leentje Persoons , et al. · 2018

Novel primaquine (PQ) and halogenaniline asymmetric fumardiamides 4a–f, potential Michael acceptors, and their reduced analogues succindiamides 5a–f were prepared by simple three-step reactions: coupling reaction between PQ and mono-ethyl …

Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway (vol 8, 2017) Open

Elisa Benedetti, Maja Pučić‐Baković, Toma Keser, Annika Wahl, Antti Hassinen , et al. · 2018

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