Tomás Ahern
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View article: Case Report: Diabetic ketoacidosis after co-administration of empagliflozin and probenecid
Case Report: Diabetic ketoacidosis after co-administration of empagliflozin and probenecid Open
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are filtered and secreted to their primary site of action in the proximal tubule of the kidney. At this site, SGLT2 inhibitors also reduce renal elimination of ketone bodies, a finding impl…
View article: Case Report: Diabetic ketoacidosis after co-administration of empagliflozin and probenecid
Case Report: Diabetic ketoacidosis after co-administration of empagliflozin and probenecid Open
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are filtered and secreted to their primary site of action in the proximal tubule of the kidney. Many commonly used medications have potential to diminish renal elimination of SGLT2 inhibito…
View article: Retrospective national cohort study of pregnancy outcomes for women with type 1 and type 2 diabetes mellitus in Republic of Ireland
Retrospective national cohort study of pregnancy outcomes for women with type 1 and type 2 diabetes mellitus in Republic of Ireland Open
Pregnancy outcomes in women with diabetes are suboptimal. Significant effort is needed to optimize the modifiable factors identified in this study.
View article: Supplementary Material for: Sitagliptin and Narrow-Band Ultraviolet-B for Moderate Psoriasis (DINUP): A Randomised Controlled Clinical Trial
Supplementary Material for: Sitagliptin and Narrow-Band Ultraviolet-B for Moderate Psoriasis (DINUP): A Randomised Controlled Clinical Trial Open
Background: Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor licensed for the treatment of type 2 diabetes mellitus (T2DM), has been reported to improve psoriasis. Objective: We compared the effects of sitagliptin treatment, a DPP-4…
View article: Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy Open
Sexual dysfunction is highly prevalent in men with severe obesity. We found an association between small fibre neuropathy with erectile dysfunction with presence of diabetes a likely a significant contributing factor. We found no associati…
View article: 284 Improving Adherence to Irish Hip Fracture Database Standards 1 and 2
284 Improving Adherence to Irish Hip Fracture Database Standards 1 and 2 Open
Background The Irish Hip Fracture Database (IHFD) National Report 2017 demonstrated poor performance across all six IHFD standards in our hospital. For the purpose of this study we focused on standards 1 and 2. IHFD standard 1: All patient…
View article: 327 The Impact of Implementation of Recommendations from the IFHD 2017 Annual Report in an Irish Model 3 Hospital
327 The Impact of Implementation of Recommendations from the IFHD 2017 Annual Report in an Irish Model 3 Hospital Open
Background Hip fractures in the older person are associated with high mortality rates (NICE, 2011). Up to 40% of patients never regain their pre-fracture mobility, 10-20% never return to live at home. The Irish Hip Fracture Database (IHFD)…
View article: Dipeptidyl Peptidase-4 Inhibition in Psoriasis Patients with Diabetes: A Double-Blind Randomized Controlled Trial
Dipeptidyl Peptidase-4 Inhibition in Psoriasis Patients with Diabetes: A Double-Blind Randomized Controlled Trial Open
treat principle.Missing data were replaced using the last observation carried forward method.Between April 25, 2014, and April 22, 2015, 9 participants were randomized to the sitagliptin arm and 11 to the gliclazide arm.Recruitment was hal…
View article: Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: Prospective results from the EMAS
Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: Prospective results from the EMAS Open
Summary Objective Limited evidence supports the use of free testosterone (FT) for diagnosing hypogonadism when sex hormone–binding globulin (SHBG) is altered. Low total testosterone (TT) is commonly encountered in obesity where SHBG is typ…
View article: Elevated luteinizing hormone despite normal testosterone levels in older men—natural history, risk factors and clinical features
Elevated luteinizing hormone despite normal testosterone levels in older men—natural history, risk factors and clinical features Open
Summary Objective Elevated luteinizing hormone ( LH ) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the developmen…
View article: Nonandrogenic Anabolic Hormones Predict Risk of Frailty: European Male Ageing Study Prospective Data
Nonandrogenic Anabolic Hormones Predict Risk of Frailty: European Male Ageing Study Prospective Data Open
These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.
View article: The androgen receptor gene CAG repeat
in relation to 4-year changes in
androgen-sensitive endpoints in
community-dwelling older European men
The androgen receptor gene CAG repeat
in relation to 4-year changes in
androgen-sensitive endpoints in
community-dwelling older European men Open
Context The androgen receptor ( AR ) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. Ho…
View article: Natural history, risk factors and clinical features of primary hypogonadism in ageing men: Longitudinal Data from the European Male Ageing Study
Natural history, risk factors and clinical features of primary hypogonadism in ageing men: Longitudinal Data from the European Male Ageing Study Open
Summary Objective In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinizing hormone ( LH ) are unclear. We describe the natural history, risk factors and clinical features associ…
View article: Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone
Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone Open
Low cFT, even in the presence of normal TT, is associated with androgen deficiency-related symptoms. Normal cFT, despite low TT, is not associated with cognate symptoms; therefore, cFT levels should be assessed in men with suspected hypogo…