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View article: Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion
Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion Open
Cancer dissemination by perineural invasion (PNI) is associated with poor outcomes in epithelial malignancies, yet the cellular interactions critical to this process are not fully defined. Single-cell transcriptomic analysis of cutaneous s…
View article: Gene expression landscape of cutaneous squamous cell carcinoma progression
Gene expression landscape of cutaneous squamous cell carcinoma progression Open
Background Cutaneous squamous cell carcinomas (cSCCs) are the second most common human cancer and have been characterized by RNA sequencing (RNA-Seq); however, the transferability of findings from individual studies may be limited by small…
View article: Extrachromosomal DNA in cutaneous squamous cell carcinoma is associated with increased nodal disease
Extrachromosomal DNA in cutaneous squamous cell carcinoma is associated with increased nodal disease Open
Extrachromosomal DNA (ecDNA) is a mechanism of oncogene amplification that occurs in many cancers and has been linked to worse patient outcomes. While ecDNA has previously been identified in cutaneous melanoma, it has yet to be described i…
View article: Gene expression landscape of cutaneous squamous cell carcinoma progression
Gene expression landscape of cutaneous squamous cell carcinoma progression Open
Background Cutaneous squamous cell carcinomas (SCC) are the second most common human cancer and have been characterized by RNA sequencing (RNA-Seq); however, the transferability of findings from individual studies may be limited by small s…
View article: Gene expression landscape of cutaneous squamous cell carcinoma progression
Gene expression landscape of cutaneous squamous cell carcinoma progression Open
Data files associated with "Gene expression landscape of cutaneous squamous cell carcinoma progression" by Bencomo and Lee. The README.md file has descriptions for each file. Funding support: This work was supported by a Scholar-Innovator …
View article: Gene expression landscape of cutaneous squamous cell carcinoma progression
Gene expression landscape of cutaneous squamous cell carcinoma progression Open
Data files associated with "Gene expression landscape of cutaneous squamous cell carcinoma progression" by Bencomo and Lee. The README.md file has descriptions for each file. Funding support: This work was supported by a Scholar-Innovator …
View article: Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET Open
Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions in the normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We perform…
View article: Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET Open
Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
View article: Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET Open
Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
View article: Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET Open
Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions in the normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We perform…
View article: MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET Open
Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions in the normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We perform…
View article: RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma
RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma Open
Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions in the normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We perform…
View article: Mutant collagen COL11A1 enhances cancerous invasion
Mutant collagen COL11A1 enhances cancerous invasion Open
Collagens are the most abundant proteins in the body and comprise the basement membranes and stroma through which cancerous invasion occurs; however, a pro-neoplastic function for mutant collagens is undefined. Here we identify COL11A1 mut…
View article: NCOG-69. SEX DIFFERENCES IN GLIOBLASTOMA PATIENT SURVIVAL AS A FUNCTION OF EXTENT OF SURGICAL RESECTION AND CYCLES OF ADJUVANT TEMOZOLOMIDE DURING STANDARD-OF-CARE REGIMENS
NCOG-69. SEX DIFFERENCES IN GLIOBLASTOMA PATIENT SURVIVAL AS A FUNCTION OF EXTENT OF SURGICAL RESECTION AND CYCLES OF ADJUVANT TEMOZOLOMIDE DURING STANDARD-OF-CARE REGIMENS Open
OBJECTIVE Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, with males more commonly affected than females(1.6:1). Despite advancements in treatments, prognosis is dismal with a median overall survival of 15 mo…