Tomáš Douda
YOU?
Author Swipe
View article: Serum Citrulline and Ornithine: Potential Markers of Coeliac Disease Activity
Serum Citrulline and Ornithine: Potential Markers of Coeliac Disease Activity Open
Introduction: To date, there is not generally accepted and universal indicator of activity, and functional integrity of the small intestine in patients with coeliac disease. The aim of our study was to investigate whether serum concentrati…
View article: Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study
Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study Open
View article: Differences in the placental pharmacokinetics of vedolizumab and ustekinumab during pregnancy in women with inflammatory bowel disease: a prospective multicentre study
Differences in the placental pharmacokinetics of vedolizumab and ustekinumab during pregnancy in women with inflammatory bowel disease: a prospective multicentre study Open
Background: Vedolizumab demonstrated different placental pharmacokinetics than other immunoglobulin G1 antibodies, leading to lower drug levels in cord blood in contrast to maternal blood at the time of delivery. The placental transfer of …
View article: The Effect of Lactobacillus casei on Experimental Porcine Inflammatory Bowel Disease Induced by Dextran Sodium Sulphate
The Effect of Lactobacillus casei on Experimental Porcine Inflammatory Bowel Disease Induced by Dextran Sodium Sulphate Open
Background: Gastrointestinal injury caused by dextran sodium sulphate (DSS) is a reliable porcine experimental model of inflammatory bowel disease (IBD). The purpose of this study was to evaluate the effect of probiotic Lactobacillus casei…
View article: Mucosal healing is not associated with better outcome during seven years of follow-up in pediatric patients with Crohn's disease
Mucosal healing is not associated with better outcome during seven years of follow-up in pediatric patients with Crohn's disease Open
Background Mucosal healing (MH) has become a perspective treatment target in patients with Crohn’s disease (CD). Data about the impact of MH on long-term outcome in pediatric patients are still scarce. Methods 76 pediatric patients with CD…
View article: The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs
The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs Open
Both single and repeated doses of memantine increased DF. Severe gastric arrhythmia and long-lasting low power after repeated administration might explain possible gastric dysmotility side effects in the chronic use of memantine.
View article: Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study
Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study Open
Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. Laboratory markers (serum , carbohydrate antigen 19-) and the length of steno…
View article: Vedolizumab, its pharmacological profile and therapeutic use
Vedolizumab, its pharmacological profile and therapeutic use Open
Douda II.interní gastroenterologická klinika, Subkatedra gastroenterologie
View article: Aktuální možnosti biologické léčby idiopatických střevních zánětů - editorial
Aktuální možnosti biologické léčby idiopatických střevních zánětů - editorial Open
View article: Innovations in treatment of IBD
Innovations in treatment of IBD Open
V uplynulých 10 letech docházelo k postupnému vývoji v léčbě idiopatických střevních zánětů.Změny se týkaly všech stupňů známé léčebné pyramidy.Spočívají ve změně postavení chirurgické léčby, způsobu použití aminosalicylátů u ulcerózní kol…
View article: Pokroky v terapii idiopatických střevních zánětů
Pokroky v terapii idiopatických střevních zánětů Open
View article: Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis
Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis Open
The goal of this prospective study was to assess non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy in patients with rheumatoid arthritis (RA) or osteoarthritis (OA) by means of non-invasive wireless capsule enteroscopy. A to…
View article: Wireless Capsule Enteroscopy in Healthy Volunteers
Wireless Capsule Enteroscopy in Healthy Volunteers Open
Introduction: The aim of our prospective study was to define endoscopy appearance of the small bowel in healthy volunteers. Method: Forty-two healthy volunteers underwent wireless capsule endoscopy, clinical investigation, laboratory tests…
View article: Use of Electrogastrography in Preclinical Studies of Cholinergic and Anticholinergic Agents in Experimental Pigs
Use of Electrogastrography in Preclinical Studies of Cholinergic and Anticholinergic Agents in Experimental Pigs Open
Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. The purpose of this study was to evaluate the effect of atropine and neostigmine on the EGG …