Tomáš Heger
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View article: European Brown hare (Lepus europaeus) as an accidental host of Trypanosoma pestanai
European Brown hare (Lepus europaeus) as an accidental host of Trypanosoma pestanai Open
In Europe, trypanosomes are not considered a serious threat to humans or domestic animals; however, their potential ecological impact on wildlife remains largely unknown. This study investigates presence of trypanosomes in European brown h…
View article: Functional Screen of Wilson Disease ATP7B Variants Reveals Residual Transport Activities
Functional Screen of Wilson Disease ATP7B Variants Reveals Residual Transport Activities Open
Wilson disease is a disorder of copper (Cu) homeostasis caused by the malfunction of Cu transporter ATP7B and associated Cu accumulation in tissues. The existence of over 700 disease‐associated variants in the ATP7B gene and a broad spectr…
View article: Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality
Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality Open
Axially chiral benzimidazoles affects microtubule organization.
View article: Correction: Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality
Correction: Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality Open
Correction for ‘Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality’ by Jana Pospíšilová et al. , Org. Biomol. Chem. , 2024, https://doi.org/10.1039/d4ob00863d.
View article: Correction: Fast-forward on P-type ATPases: recent advances on structure and function
Correction: Fast-forward on P-type ATPases: recent advances on structure and function Open
Stock, C., Heger, T., Hansen, S.B., Larsen, S.T., Habeck, M. Dieudonné, T., Driller, R. and Nissen, P. (2023) Fast-forward on P-type ATPases: recent advances on structure and function. Biochem. Soc. Trans.51; 1347–1360. doi: https://doi.or…
View article: Fast-forward on P-type ATPases: recent advances on structure and function
Fast-forward on P-type ATPases: recent advances on structure and function Open
P-type ATPase are present in nearly all organisms. They maintain electrochemical gradients for many solutes, in particular ions, they control membrane lipid asymmetry, and are crucial components of intricate signaling networks. All P-type …
View article: Blood Parasites and Health Status of Hibernating and Non-Hibernating Noctule Bats (Nyctalus noctula)
Blood Parasites and Health Status of Hibernating and Non-Hibernating Noctule Bats (Nyctalus noctula) Open
Co-existence of bats with a wide range of infectious agents relates to their co-evolutionary history and specific physiology. Here, we examined blood samples collected during hibernation and the post-hibernation period to assess the influe…
View article: Procyanidin C1 from Viola odorata L. inhibits Na+,K+-ATPase
Procyanidin C1 from Viola odorata L. inhibits Na+,K+-ATPase Open
Members of the Viola genus play important roles in traditional Asian herbal medicine. This study investigates the ability of Viola odorata L. extracts to inhibit Na + ,K + -ATPase, an essential animal enzyme responsible for membrane potent…
View article: Reproductive toxicity of heavy metals in fallow deer in vitro
Reproductive toxicity of heavy metals in fallow deer in vitro Open
Sertoli cells play a crucial role in male fertility through boosting and regulating the differentiation of spermatogonial stem cells into mature sperm during spermatogenesis. Female ovarian follicles are responsible for the production of m…
View article: Active surveillance for antibodies confirms circulation of lyssaviruses in Palearctic bats
Active surveillance for antibodies confirms circulation of lyssaviruses in Palearctic bats Open
Background Palearctic bats host a diversity of lyssaviruses, though not the classical rabies virus (RABV). As surveillance for bat rabies over the Palearctic area covering Central and Eastern Europe and Siberian regions of Russia has been …
View article: Phagocyte activity reflects mammalian homeo- and hetero-thermic physiological states
Phagocyte activity reflects mammalian homeo- and hetero-thermic physiological states Open
Background Emergence of both viral zoonoses from bats and diseases that threaten bat populations has highlighted the necessity for greater insights into the functioning of the bat immune system. Particularly when considering hibernating te…
View article: Trypanosomes in Eastern and Central European bats
Trypanosomes in Eastern and Central European bats Open
Bats are presumed primary hosts of trypanosomes of the subgenus Schizotrypanum , including the human pathogen Trypanosoma cruzi . As such, research on bat trypanosomes has been focused on South America, where Chagas disease is a serious is…
View article: Fresh semen characteristics in captive accipitrid and falconid birds of prey
Fresh semen characteristics in captive accipitrid and falconid birds of prey Open
Artificial insemination (AI) is the most frequently used assisted reproductive technique for captive propagation of rare avian species. As semen quality is critical for reproductive success, baseline data are needed for evaluating and sele…
View article: Polychlorinated biphenyl toxicity in the thyroid gland of wild ungulates: an in vitro model
Polychlorinated biphenyl toxicity in the thyroid gland of wild ungulates: an in vitro model Open
Polychlorinated biphenyls (PCBs) are carcinogens causing endocrine disruption. While production of PCBs is now banned, wildlife exposure still occurs due to environmental contamination. We investigated thyroid toxicity in wild ungulates us…
View article: Measurement of phagocyte activity in heterotherms
Measurement of phagocyte activity in heterotherms Open
The heterotherm immune system undergoes significant variation in response to life cycle periodicity and torpor. As heterothermic bats are important reservoirs of zoonotic agents and modulation of immune activity can affect host-pathogen in…
View article: Reproductive toxicity of fluoroquinolones in birds
Reproductive toxicity of fluoroquinolones in birds Open
Fluoroquinolones induce complex adverse effects on avian embryonic development, considerably reducing the performance of incubated eggs and hatching chicks. Cardiotoxicity, which quickens embryonic heart rate, meant that the total number o…
View article: Additional file 1: of Reproductive toxicity of fluoroquinolones in birds
Additional file 1: of Reproductive toxicity of fluoroquinolones in birds Open
Table S1. Reproductive toxicity of fluoroquinolones in birds: supporting data. Measured data are given for 1. Chicken embryonic heart rate following exposure to fluoroquinolones (heartbeats per minute) and 2. Blood biochemistry parameters …