Tomas Ilginis
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View article: Novel Blood-Biomarkers to Detect Retinal Neurodegeneration and Inflammation in Diabetic Retinopathy
Novel Blood-Biomarkers to Detect Retinal Neurodegeneration and Inflammation in Diabetic Retinopathy Open
To investigate levels of specific plasma-biomarkers related to neurodegeneration and inflammation in patients with different chronic degenerative retinal diseases, using an ultrasensitive technology called ‘single molecule array’ (SiMoA). …
View article: Proteomic analysis of diabetic retinopathy identifies potential plasma-protein biomarkers for diagnosis and prognosis
Proteomic analysis of diabetic retinopathy identifies potential plasma-protein biomarkers for diagnosis and prognosis Open
Objectives To identify molecular pathways and prognostic- and diagnostic plasma-protein biomarkers for diabetic retinopathy at various stages. Methods This exploratory, cross-sectional proteomics study involved plasma from 68 adults, inclu…
View article: Whole exome sequencing of patients with varicella-zoster virus and herpes simplex virus induced acute retinal necrosis reveals rare disease-associated genetic variants
Whole exome sequencing of patients with varicella-zoster virus and herpes simplex virus induced acute retinal necrosis reveals rare disease-associated genetic variants Open
Purpose Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are neurotropic human alphaherpesviruses endemic worldwide. Upon primary infection, both viruses establish lifelong latency in neurons and reactivate intermittently to cau…
View article: Assessment of Anterior Uveitis Through Anterior-Segment Optical Coherence Tomography and Artificial Intelligence-Based Image Analyses
Assessment of Anterior Uveitis Through Anterior-Segment Optical Coherence Tomography and Artificial Intelligence-Based Image Analyses Open
Automated AI-based AS-OCT image analysis suggests a noninvasive and quantitative assessment of AC inflammation with clear potential application in early detection and management of anterior uveitis.
View article: Automated artificial intelligence‐based system for clinical follow‐up of patients with age‐related macular degeneration
Automated artificial intelligence‐based system for clinical follow‐up of patients with age‐related macular degeneration Open
Purpose In this study, we investigate the potential of a novel artificial intelligence‐based system for autonomous follow‐up of patients treated for neovascular age‐related macular degeneration (AMD). Methods A temporal deep learning model…
View article: Iron overload and iron chelating agent exposure in anemia-associated outer retinal degeneration: a case report and review of the literature
Iron overload and iron chelating agent exposure in anemia-associated outer retinal degeneration: a case report and review of the literature Open
Background Deferoxamine retinopathy is the informally designated term used to describe a characteristic pattern of outer retinal degeneration in iron-overloaded chronic anemia patients who are treated with deferoxamine. We hypothesize that…
View article: Detection of oedema on optical coherence tomography images using deep learning model trained on noisy clinical data
Detection of oedema on optical coherence tomography images using deep learning model trained on noisy clinical data Open
Purpose To meet the demands imposed by the continuing growth of the Age‐related macular degeneration (AMD) patient population, automation of follow‐ups by detecting retinal oedema using deep learning might be a viable approach. However, pr…
View article: A Missense Mutation in <i>RAB28</i> in a Family with Cone-Rod Dystrophy and Postaxial Polydactyly Prevents Localization of <i>RAB28</i> to the Primary Cilium
A Missense Mutation in <i>RAB28</i> in a Family with Cone-Rod Dystrophy and Postaxial Polydactyly Prevents Localization of <i>RAB28</i> to the Primary Cilium Open
The missense variant in RAB28 is classified as likely pathogenic with functional effect on protein localization. The combination of retinal dystrophy and PAP are well known from ciliopathies; however, more data are needed to finally conclu…
View article: Agreement of swept-source and spectral-domain optical coherence-tomography retinal thickness measurements in neovascular age-related macular degeneration
Agreement of swept-source and spectral-domain optical coherence-tomography retinal thickness measurements in neovascular age-related macular degeneration Open
Agreement of swept-source and spectral-domain optical coherence-tomography retinal thickness measurements in neovascular age-related macular degeneration Daren Hanumunthadu,1 Tomas Ilginis,1 Kamaljit S Balaggan,1,2 Praveen J Patel1 On beha…