Tomáš Vaisar
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View article: Focal Adhesion Kinase Drives Rho/ROCK and mTOR Signaling to Protect and Augment Aortic Dissections
Focal Adhesion Kinase Drives Rho/ROCK and mTOR Signaling to Protect and Augment Aortic Dissections Open
View article: Elevated apolipoprotein C3 heightens atherosclerosis risk by mediating arterial accumulation of free cholesterol and local inflammation in diabetes
Elevated apolipoprotein C3 heightens atherosclerosis risk by mediating arterial accumulation of free cholesterol and local inflammation in diabetes Open
View article: HDL proteome: from its characterization to quantitative measurements in particle subspecies and functional associations
HDL proteome: from its characterization to quantitative measurements in particle subspecies and functional associations Open
The HDL proteome is undisputedly related to the HDL function. The development of new approaches to isolate HDL subspecies, together with the implementation of consistent quantification strategies, is needed to provide new insights into the…
View article: Effect of complete, lifelong ANGPTL3 deficiency on triglyceride-rich lipoprotein kinetics
Effect of complete, lifelong ANGPTL3 deficiency on triglyceride-rich lipoprotein kinetics Open
Angiopoietin-like 3 (ANGPTL3) inhibits lipases that hydrolyze triglycerides (TGs) in TG-rich lipoproteins (TRLs). We evaluated TRL-TGs, TRL particle (apolipoprotein B), palmitate, and glucose kinetics during a mixed-meal test that included…
View article: Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL
Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL Open
View article: APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1
APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1 Open
View article: Epigenetic programming of host lipid metabolism associated with resistance to TST/IGRA conversion after exposure to <i>Mycobacterium tuberculosis</i>
Epigenetic programming of host lipid metabolism associated with resistance to TST/IGRA conversion after exposure to <i>Mycobacterium tuberculosis</i> Open
Mycobacterium tuberculosis (Mtb) exposure leads to a range of outcomes including clearance, latent TB infection (LTBI), and pulmonary tuberculosis (TB). Some heavily exposed individuals resist tuberculin skin test (TST) and interferon-gamm…
View article: Relationships between HDL subpopulation proteome and HDL function in overweight/obese people with and without coronary heart disease
Relationships between HDL subpopulation proteome and HDL function in overweight/obese people with and without coronary heart disease Open
View article: High‐Density Lipoprotein Particle Concentration and Size Predict Incident Coronary Artery Disease Events in a Cohort With Type 1 Diabetes
High‐Density Lipoprotein Particle Concentration and Size Predict Incident Coronary Artery Disease Events in a Cohort With Type 1 Diabetes Open
Background The cholesterol efflux capacity of high density lipoprotein (HDL) is negatively associated with cardiovascular risk. Small HDL particles account almost quantitatively for cholesterol efflux capacity, perhaps mediated through eff…
View article: Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis
Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis Open
BACKGROUND: Individuals with type 1 diabetes (T1D) generally have normal or even higher HDL (high-density lipoprotein)-cholesterol levels than people without diabetes yet are at increased risk for atherosclerotic cardiovascular disease (CV…
View article: A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling
A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling Open
View article: Epigenetic programming of host lipid metabolism associates with resistance to TST/IGRA conversion after exposure to<i>Mycobacterium tuberculosis</i>
Epigenetic programming of host lipid metabolism associates with resistance to TST/IGRA conversion after exposure to<i>Mycobacterium tuberculosis</i> Open
Mycobacterium tuberculosis (Mtb) exposure leads to a range of outcomes including clearance, latent TB infection (LTBI), and pulmonary tuberculosis (TB). Some heavily exposed individuals resist tuberculin skin test (TST) and interferon gamm…
View article: Sex differences in the associations of HDL particle concentration and cholesterol efflux capacity with incident coronary artery disease in type 1 diabetes: The RETRO HDLc cohort study
Sex differences in the associations of HDL particle concentration and cholesterol efflux capacity with incident coronary artery disease in type 1 diabetes: The RETRO HDLc cohort study Open
View article: Does small HDL’s function improve when lipid-lowering alters its composition?
Does small HDL’s function improve when lipid-lowering alters its composition? Open
Metabolic syndrome associates with a markedly increased risk for cardiovascular disease (CVD) and very frequently with dyslipidemia, which is characterized by elevated plasma triglycerides and lower levels of high-density lipoprotein-chole…
View article: PPI DataHub Project Data Package: High-density Lipoprotein (HDL) Structure and Function Proteomics
PPI DataHub Project Data Package: High-density Lipoprotein (HDL) Structure and Function Proteomics Open
The purpose of this experiment was to investigate how the interactions between APOA1 and APOA2 on the surface of high-density lipoproteins (HDL) impact particle function. Interactions were investigated on HDL isolated from human blood plas…
View article: Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs
Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs Open
BACKGROUND: Cholesterol efflux capacity (CEC) predicts cardiovascular disease independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL particles are potent promoters of macrophage CEC by the ABCA1 (ATP-binding…
View article: HDL Particle Concentration and Size Predict Incident Coronary Artery Disease Events in People with Type 1 Diabetes
HDL Particle Concentration and Size Predict Incident Coronary Artery Disease Events in People with Type 1 Diabetes Open
Background Cholesterol efflux capacity (CEC) negatively correlates with cardiovascular disease risk. Small HDL particles account almost quantitively for CEC, perhaps mediated through efflux of outer leaflet plasma membrane phospholipids by…
View article: Flipped C-Terminal Ends of APOA1 Promote ABCA1-dependent Cholesterol Efflux by Small HDLs
Flipped C-Terminal Ends of APOA1 Promote ABCA1-dependent Cholesterol Efflux by Small HDLs Open
Background Cholesterol efflux capacity (CEC) predicts cardiovascular disease (CVD) independently of HDL cholesterol (HDL-C) levels. Isolated small HDL particles are potent promoters of macrophage CEC by the ABCA1 pathway, but the underlyin…
View article: A High-Throughput PIXUL–Matrix-Based Toolbox to Profile Frozen and Formalin-Fixed Paraffin-Embedded Tissues Multiomes
A High-Throughput PIXUL–Matrix-Based Toolbox to Profile Frozen and Formalin-Fixed Paraffin-Embedded Tissues Multiomes Open
Large-scale high-dimensional multiomics studies are essential to unravel molecular complexity in health and disease. We developed an integrated system for tissue sampling (CryoGrid), analytes preparation (PIXUL), and downstream multiomic a…
View article: Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health
Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health Open
Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble plasma high-density lipoproteins (HDLs), which are a compositionally and structurally diverse spectrum of nanoparticles with pleiotropic functionality. …
View article: MultiomicsTracks96: A high throughput PIXUL-Matrix-based toolbox to profile frozen and FFPE tissues multiomes
MultiomicsTracks96: A high throughput PIXUL-Matrix-based toolbox to profile frozen and FFPE tissues multiomes Open
Background The multiome is an integrated assembly of distinct classes of molecules and molecular properties, or “omes,” measured in the same biospecimen. Freezing and formalin-fixed paraffin-embedding (FFPE) are two common ways to store ti…
View article: Association Between Triglycerides and Incident Cognitive Impairment in Black and White Adults in the Reasons for Geographic and Racial Differences in Stroke Study
Association Between Triglycerides and Incident Cognitive Impairment in Black and White Adults in the Reasons for Geographic and Racial Differences in Stroke Study Open
Background Elevated nonfasting triglycerides were associated with non‐Alzheimer dementia in a recent study. However, this study neither evaluated the association of fasting triglycerides with incident cognitive impairment (ICI) nor adjuste…
View article: Apolipoprotein C3 induces inflammasome activation only in its delipidated form
Apolipoprotein C3 induces inflammasome activation only in its delipidated form Open
View article: Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury
Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury Open
Background Genetic variants in apolipoprotein L1 (APOL1), a protein that protects humans from infection with African trypanosomes, explain a substantial proportion of the excess risk of chronic kidney disease affecting individuals with sub…
View article: Editorial: Insights in lipids in cardiovascular disease: 2021
Editorial: Insights in lipids in cardiovascular disease: 2021 Open
EDITORIAL article Front. Cardiovasc. Med., 15 July 2022Sec. Lipids in Cardiovascular Disease https://doi.org/10.3389/fcvm.2022.940153
View article: Effect of Selective Androgen Receptor Modulator on Cholesterol Efflux Capacity, Size, and Subspecies of HDL Particles
Effect of Selective Androgen Receptor Modulator on Cholesterol Efflux Capacity, Size, and Subspecies of HDL Particles Open
Context Selective androgen receptor modulators (SARMs), because of their preferential muscle vs prostate selectivity, are being developed for muscle-wasting conditions. Oral SARMs suppress high-density lipoprotein cholesterol (HDL-C) but t…
View article: 10,12-Conjugated linoleic acid supplementation improves HDL composition and function in mice
10,12-Conjugated linoleic acid supplementation improves HDL composition and function in mice Open
View article: Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open
Objective: Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). Research Design and Methods: We performed a case-control st…
View article: Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open
OBJECTIVE Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS We performed a case-control stud…
View article: Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open
Objective: Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). Research Design and Methods: We performed a case-control st…