Tomasz Blazejewski
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View article: Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity
Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity Open
Current protein engineering methods are inadequate to explore the combinatorial potential offered by nature’s vast repertoire of protein domains–limiting our ability to create optimal synthetic tools. To overcome this barrier, we develop a…
View article: GENTANGLE: integrated computational design of gene entanglements
GENTANGLE: integrated computational design of gene entanglements Open
Summary The design of two overlapping genes in a microbial genome is an emerging technique for adding more reliable control mechanisms in engineered organisms for increased stability. The design of functional overlapping gene pairs is a ch…
View article: GENTANGLE: integrated computational design of gene entanglements
GENTANGLE: integrated computational design of gene entanglements Open
Summary The design of two overlapping genes in a microbial genome is an emerging technique for adding more reliable control mechanisms in engineered organisms for increased safety. The design of functional gene pairs is a challenging proce…
View article: High-throughput microbial culturomics using automation and machine learning
High-throughput microbial culturomics using automation and machine learning Open
Pure bacterial cultures remain essential for detailed experimental and mechanistic studies in microbiome research, and traditional methods to isolate individual bacteria from complex microbial ecosystems are labor-intensive, difficult-to-s…
Generative Models for Synthetic Biology Open
Over the past several years, the fields of synthetic biology and machine learning have demonstrated marked advances in the scale of their capabilities and the success of their applications. The work presented in this thesis focuses on the …