Tomasz Kos
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View article: A systematic review on the relationship between psychological resilience, cognitive emotion regulation strategies, and climate anxiety
A systematic review on the relationship between psychological resilience, cognitive emotion regulation strategies, and climate anxiety Open
The increasing prevalence of climate anxiety and its associations with mental health disorders have encouraged the scientific community to explore how individuals may effectively cope with this complex phenomenon. While existing research h…
View article: Simultaneous 5-HT1BR agonist/5-HT6R antagonist action as a potential treatment of Parkinson’s disease and its comorbidities
Simultaneous 5-HT1BR agonist/5-HT6R antagonist action as a potential treatment of Parkinson’s disease and its comorbidities Open
Parkinson's disease (PD) treatment focuses mainly on the augmentation of dopamine transmission, but to alleviate adverse motor effects accompanying L-DOPA use, additional treatments with serotonergic (5-HT) medications may be considered. W…
View article: A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects
A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects Open
Background: Phosphodiesterase 10A (PDE10A) is expressed almost exclusively in the striatum and its inhibition is suggested to offer potential treatment in disorders associated with basal ganglia. We evaluated the selectivity, cytotoxicity,…
View article: Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT<sub>3</sub> and 5-HT<sub>6</sub> Receptor Antagonist with Antipsychotic and Procognitive Properties
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT<sub>3</sub> and 5-HT<sub>6</sub> Receptor Antagonist with Antipsychotic and Procognitive Properties Open
In line with recent clinical trials demonstrating that ondansetron, a 5-HT3 receptor (5-HT3R) antagonist, ameliorates cognitive deficits of schizophrenia and the known procognitive effects of 5-HT6 receptor…
View article: Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects Open
View article: Novel non-sulfonamide 5-HT 6 receptor partial inverse agonist in a group of imidazo[4,5- b ]pyridines with cognition enhancing properties
Novel non-sulfonamide 5-HT 6 receptor partial inverse agonist in a group of imidazo[4,5- b ]pyridines with cognition enhancing properties Open
View article: Comparison of the Psychopharmacological Effects of Tiletamine and Ketamine in Rodents
Comparison of the Psychopharmacological Effects of Tiletamine and Ketamine in Rodents Open
View article: The role of <scp>NMDA</scp> receptor‐dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors
The role of <span>NMDA</span> receptor‐dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors Open
Activity of the brain's noradrenergic (NA) neurons plays a major role in cognitive processes, including the ability to adapt behavior to changing environmental circumstances. Here, we used the NR1 DbhCre transgenic mouse strain to test how…
View article: Novel 5-HT7R antagonists, arylsulfonamide derivatives of (aryloxy)propyl piperidines: Add-on effect to the antidepressant activity of SSRI and DRI, and pro-cognitive profile
Novel 5-HT7R antagonists, arylsulfonamide derivatives of (aryloxy)propyl piperidines: Add-on effect to the antidepressant activity of SSRI and DRI, and pro-cognitive profile Open
View article: Novel 1<i>H</i>-Pyrrolo[3,2-<i>c</i>]quinoline Based 5-HT<sub>6</sub> Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease
Novel 1<i>H</i>-Pyrrolo[3,2-<i>c</i>]quinoline Based 5-HT<sub>6</sub> Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease Open
Modulators of the serotonin 5-HT6 receptor (5-HT6R) offer a promising strategy for the treatment of the cognitive deficits that are associated with dementia and Alzheimer's disease. Herein, we report the design, synthesis, and characteriza…
View article: <i>N</i>1-Azinylsulfonyl-1<i>H</i>-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties
<i>N</i>1-Azinylsulfonyl-1<i>H</i>-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties Open
A series of N1-azinylsulfonyl-3-(1,2,3,6,tetrahyrdopyridin-4-yl)-1H-indole derivatives was designed to obtain highly potent 5-HT6 receptor ligands. The study allowed for the identification of 25 (4-{[5-methoxy-3-(1,2,3,6-tetrahydropyridin-…
View article: N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT7 receptor selectivity versus multireceptor profile
N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT7 receptor selectivity versus multireceptor profile Open
View article: Pro‐cognitive activity in rats of 3‐furan‐2‐yl‐N‐p‐tolyl‐acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor
Pro‐cognitive activity in rats of 3‐furan‐2‐yl‐N‐p‐tolyl‐acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor Open
Background and Purpose α7 nicotinic acetylcholine receptors (α7 nAChRs) may represent useful targets for cognitive improvement. The aim of this study is to compare the pro‐cognitive activity of selective α7‐nAChR ligands, including the par…
View article: Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test
Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test Open
Objective The N -methyl- d -aspartate receptor (NMDAR) antagonist ketamine, produces rapid and enduring antidepressant effect in patients with treatment-resistant depression. Similar dramatic effects have not been observed in clinical tria…
View article: Arylsulfonamide derivatives of (aryloxy)ethylpiperidines as selective 5-HT<sub>7</sub> receptor antagonists and their psychotropic properties
Arylsulfonamide derivatives of (aryloxy)ethylpiperidines as selective 5-HT<sub>7</sub> receptor antagonists and their psychotropic properties Open
A novel series of potent 5-HT7 receptor antagonist and their antidepressant, anxiolytic and pro-cognitive properties is described.