Tomasz P. Lehmann
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View article: Structural and biomechanical analysis of femurs from mice treated with diclofenac, miR-15b and miR-365
Structural and biomechanical analysis of femurs from mice treated with diclofenac, miR-15b and miR-365 Open
Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain, but they have side effects, including the inhibition of bone healing. Diclofenac (DF), a member of the NSAID group, affects bone health adversely. One potential …
View article: Injectable PLGA Microscaffolds with Laser‐Induced Enhanced Microporosity for Nucleus Pulposus Cell Delivery
Injectable PLGA Microscaffolds with Laser‐Induced Enhanced Microporosity for Nucleus Pulposus Cell Delivery Open
Intervertebral disc (IVD) degeneration is a leading cause of lower back pain (LBP). Current treatments primarily address symptoms without halting the degenerative process. Cell transplantation offers a promising approach for early‐stage IV…
View article: Novel genetic variants potentially associated with the pathogenesis of coronary artery aneurysm: whole-exome sequencing analysis
Novel genetic variants potentially associated with the pathogenesis of coronary artery aneurysm: whole-exome sequencing analysis Open
View article: Potential applications of using tissue-specific EVs in targeted therapy and vaccinology
Potential applications of using tissue-specific EVs in targeted therapy and vaccinology Open
Many cell types secrete spherical membrane bodies classified as extracellular vesicles (EVs). EVs participate in intercellular communication and are present in body fluids, including blood, lymph, and cerebrospinal fluid. The time of EVs s…
View article: Circulating miRNA-451a and miRNA-328-3p as Potential Markers of Coronary Artery Aneurysmal Disease
Circulating miRNA-451a and miRNA-328-3p as Potential Markers of Coronary Artery Aneurysmal Disease Open
MicroRNAs (miRNAs) are currently investigated as crucial regulatory factors which may serve as a potential therapeutic target. Reports on the role of miRNA in patients with coronary artery aneurysmal disease (CAAD) are limited. The present…
View article: Gene Expression in MC3T3-E1 Cells Treated with Diclofenac and Methylprednisolone
Gene Expression in MC3T3-E1 Cells Treated with Diclofenac and Methylprednisolone Open
Nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids (GCs) are often used to treat articular-skeletal disorders. The extended use of NSAIDs and GCs have adverse effects on bone metabolism, reducing bone quality and impairing f…
View article: In silico and in vitro analysis of the impact of single substitutions within EXO-motifs on Hsa-MiR-1246 intercellular transfer in breast cancer cell
In silico and in vitro analysis of the impact of single substitutions within EXO-motifs on Hsa-MiR-1246 intercellular transfer in breast cancer cell Open
View article: Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries
Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries Open
To understand the mechanism underlying coronary artery abnormal dilatation (CAAD), the present study identified and compared the expression of circulating microRNAs (miRNAs) in three groups of patients. Group 1 included 20 patients with CA…
View article: Serum matrix metalloproteinase-8 level in patients with coronary artery abnormal dilatation
Serum matrix metalloproteinase-8 level in patients with coronary artery abnormal dilatation Open
RESEARCH LETTER MMP -8 in coronary aneurysmal dilatation 1 and control subjects with angiographically nor mal coronary arteries (NCA). Patients and methods Study design and patient selectionThe presented data result from a sub analysis of …
View article: Mechanical properties of the mouse femur after treatment with diclofenac and running exercises
Mechanical properties of the mouse femur after treatment with diclofenac and running exercises Open
Purpose: The flexible properties of the bone are essential for the movement and protection of vital organs. The ability of a bone to resist fractures under the influence of large muscles and physical activity depends on its established mec…
View article: Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro—The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo
Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro—The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo Open
SPX (spexin) and its receptors GalR2 and GalR3 (galanin receptor subtype 2 and galanin receptor subtype 3) play an important role in the regulation of lipid and carbohydrate metabolism in human and animal fat tissue. However, little is sti…
View article: The Regulation of Collagen Processing by miRNAs in Disease and Possible Implications for Bone Turnover
The Regulation of Collagen Processing by miRNAs in Disease and Possible Implications for Bone Turnover Open
This article describes several recent examples of miRNA governing the regulation of the gene expression involved in bone matrix construction. We present the impact of miRNA on the subsequent steps in the formation of collagen type I. Colla…
View article: Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms
Involvement of Angiogenesis in the Pathogenesis of Coronary Aneurysms Open
The present study aimed to evaluate the plasma concentration of pro and antiangiogenic factors and their role in the pathogenesis of coronary artery abnormal dilation (CAAD). We measured the plasma concentration of matrix metalloproteinase…
View article: The itinerary of circulating miRNAs – implications for cancer progression and diagnosis
The itinerary of circulating miRNAs – implications for cancer progression and diagnosis Open
microRNAs (miRNAs) are non-coding RNAs that regulate gene expression and protect cells from foreign nucleic acids. miRNA is produced in the nucleus and processed in the cytoplasm. These small nucleic acid molecules are released from cells …
View article: Trabecular bone remodelling in the femur of C57BL/6J mice treated with diclofenac in combination with treadmill exercise
Trabecular bone remodelling in the femur of C57BL/6J mice treated with diclofenac in combination with treadmill exercise Open
Purpose: Analgesic treatment with diclofenac deteriorates bone structure and decreases biomechanical properties. This bone loss has been though to be reversed by training. The impact of exercise on bone treated with diclofenac (DF) has rem…
View article: In Vitro and in Silico Analysis of miR-125a with rs12976445 Polymorphism in Breast Cancer Patients
In Vitro and in Silico Analysis of miR-125a with rs12976445 Polymorphism in Breast Cancer Patients Open
Background: Breast cancer affects over 2 million women yearly. Its early detection allows for successful treatment, which motivates to research factors that enable an accurate diagnosis. miR-125a is one of them, correlating with different …
View article: Recovery from bone loss, diminished mineral density and strength in mice after treatment with steroidal and nonsteroidal anti-inflammatory drugs by injection of exosomes enriched with agomir miRNAs
Recovery from bone loss, diminished mineral density and strength in mice after treatment with steroidal and nonsteroidal anti-inflammatory drugs by injection of exosomes enriched with agomir miRNAs Open
The project “Recovery from bone loss, diminished mineral density and strength in mice after treatment with steroidal and nonsteroidal anti-inflammatory drugs by injection of exosomes enriched with agomir miRNAs” is an animal experiment pro…
View article: Transforming growth factor β mediates communication of co‐cultured human nucleus pulposus cells and mesenchymal stem cells
Transforming growth factor β mediates communication of co‐cultured human nucleus pulposus cells and mesenchymal stem cells Open
Intervertebral disc (IVD) consists of surrounding tissue annulus fibrosus and central nucleus pulposus, which are partially degenerative in scoliotic IVDs. Successful regeneration of scoliotic alterations requires cognition of critical par…
View article: Quantification of the asymmetric migration of the lipophilic dyes, DiO and DiD, in homotypic co-cultures of chondrosarcoma SW-1353 cells
Quantification of the asymmetric migration of the lipophilic dyes, DiO and DiD, in homotypic co-cultures of chondrosarcoma SW-1353 cells Open
DiO and DiD are lipophilic cell labelling dyes used in the staining of cells in vivo and in vitro. The aim of the present study was to quantify the asymmetrical distribution of dyes in co‑cultured cells and to measure the intercellular tra…
View article: Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer
Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer Open
MicroRNAs (miRNAs/miRs) are a class of short, single‑stranded nucleic acids, which have been investigated as potential molecular markers for various types of cancer. The gold‑standard and most sensitive method for comparing miRNA levels in…