Tomasz Rutkowski
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View article: Xevinapant or Placebo Plus Platinum-Based Chemoradiotherapy in Unresected Locally Advanced Squamous Cell Carcinoma of the Head and Neck (TrilynX): A Randomized, Phase III Study
Xevinapant or Placebo Plus Platinum-Based Chemoradiotherapy in Unresected Locally Advanced Squamous Cell Carcinoma of the Head and Neck (TrilynX): A Randomized, Phase III Study Open
PURPOSE TrilynX was a randomized, double-blind, phase III study evaluating the addition of xevinapant (an inhibitor of apoptosis proteins inhibitor) or placebo to chemoradiotherapy (CRT) in patients with unresected locally advanced squamou…
View article: LBA48 BURAN: A phase III study of buparlisib (BUP) plus paclitaxel (PAC) in patients with PD-1(PD-L1)-pretreated recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)
LBA48 BURAN: A phase III study of buparlisib (BUP) plus paclitaxel (PAC) in patients with PD-1(PD-L1)-pretreated recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) Open
View article: Radiation therapy in the presence of non-transvenous cardiac implantable electronic devices: A case series
Radiation therapy in the presence of non-transvenous cardiac implantable electronic devices: A case series Open
View article: The acute changes in parameters of cardiac implantable electronic devices in patients undergoing radiation therapy
The acute changes in parameters of cardiac implantable electronic devices in patients undergoing radiation therapy Open
Background The number of patients with cardiac implantable electronic devices (CIEDs) requiring effective cancer treatment, including radiotherapy (RT), is increasing year by year. A potentially harmful effect of RT on CIEDs depending on t…
View article: Does nutritional support prevent severe mucositis in patients with head and neck cancer treated with chemoradiotherapy? A systematic review and meta-analysis
Does nutritional support prevent severe mucositis in patients with head and neck cancer treated with chemoradiotherapy? A systematic review and meta-analysis Open
Despite the undeniable role of NC±ONS for patients with HNC undergoing CHRT, we found it insufficient to avoid grade ≥3 CHRT-related mucositis. Further research should be conducted to determine recomendations how to decrease the risk of or…
View article: Long term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers
Long term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers Open
The oral cancer treatment of choice is surgical excision with an organ preservation, if it is possible. Radiation therapy is commonly used as a postoperative treatment. Delivering radiation dose during surgery, defined as intraoperative ra…
View article: Dermoscopic evolution of acute to chronic radiation dermatitis in head and neck cancer patients undergoing radiochemotherapy: a study of two cases
Dermoscopic evolution of acute to chronic radiation dermatitis in head and neck cancer patients undergoing radiochemotherapy: a study of two cases Open
View article: Nivolumab Added to Cisplatin-Radiotherapy Versus Cisplatin-Radiotherapy Alone after Surgery for Patients with Squamous Cell Carcinoma of the Head and Neck at High-Risk of Relapse (GORTEC 2018-01 NIVOPOST-OP): A Randomised, Open-Label, Phase 3 Trial
Nivolumab Added to Cisplatin-Radiotherapy Versus Cisplatin-Radiotherapy Alone after Surgery for Patients with Squamous Cell Carcinoma of the Head and Neck at High-Risk of Relapse (GORTEC 2018-01 NIVOPOST-OP): A Randomised, Open-Label, Phase 3 Trial Open
View article: Nivolumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: Results of Polish multicenter observational study
Nivolumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: Results of Polish multicenter observational study Open
Patients with head and neck squamous cell carcinoma (HNSCC) who have progressed following primary treatment (PT) have a poor prognosis. In this group, nivolumab has been demonstrated to significantly improve outcomes. This study presents t…
View article: The Role of Ultrasound-Based Monitoring of Bladder Volume in Patients with Prostate Cancer during CyberKnife Stereotactic Radiosurgery
The Role of Ultrasound-Based Monitoring of Bladder Volume in Patients with Prostate Cancer during CyberKnife Stereotactic Radiosurgery Open
(1) Background: For patients irradiated due to prostate cancer, monitoring of bladder volume (BV) is crucial for accuracy of radiation delivery and minimizing exposure to surrounding healthy tissues. Due to the limited imaging capabilities…
View article: Navigating a New Frontier: Evaluating Leadless Pacemakers in Proton Therapy
Navigating a New Frontier: Evaluating Leadless Pacemakers in Proton Therapy Open
View article: The Role of Single Nucleotide Polymorphisms in MicroRNA Genes in Head and Neck Squamous Cell Carcinomas: Susceptibility and Prognosis
The Role of Single Nucleotide Polymorphisms in MicroRNA Genes in Head and Neck Squamous Cell Carcinomas: Susceptibility and Prognosis Open
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide. The identification of molecular alterations adding to the individual risk of HNSCC development and progression is one of the most imp…
View article: Radiotherapy in patients with breast cancer and Li-Fraumeni syndrome — a narrative review
Radiotherapy in patients with breast cancer and Li-Fraumeni syndrome — a narrative review Open
Li-Fraumeni syndrome (LFS) is a rare disorder that increases the risk of many cancers, including breast cancer (BC), leukemia, soft-tissue sarcomas, central nervous system tumors, and adrenocortical carcinomas. Several previous clinical ob…
View article: The management of oral cancer – current standards and future perspectives. Review of the literature
The management of oral cancer – current standards and future perspectives. Review of the literature Open
Oral cancer (OC) is one of the most common cancers of the head and neck region, with approximately 1,950 new cases reported in Poland in 2019. The main factors contributing to the development of OC are cigarette smoking and excessive alcoh…
View article: Safety and feasibility concerns of radiotherapy in the presence of subcutaneous implantable cardioverter-defibrillator
Safety and feasibility concerns of radiotherapy in the presence of subcutaneous implantable cardioverter-defibrillator Open
Introduction Radiotherapy (RT) in patients with cardiac implantable electronic devices (CIED) is performed increasingly more frequently. Currently, there is no evidence, whether RT in patients with subcutaneous implantable cardioverter-def…
View article: Dermoscopy of Chronic Radiation-Induced Dermatitis in Patients with Head and Neck Cancers Treated with Radiotherapy
Dermoscopy of Chronic Radiation-Induced Dermatitis in Patients with Head and Neck Cancers Treated with Radiotherapy Open
Radiotherapy (RT) is an integral part of many cancer treatment protocols. Chronic radiation-induced dermatitis (CRD) is a cutaneous toxicity that occurs in one-third of all patients treated with this method. CRD is usually observed several…
View article: Pretreatment Circulating HPV16 DNA Viral Load Predicts Risk of Distant Metastasis in Patients with HPV16-Positive Oropharyngeal Cancer
Pretreatment Circulating HPV16 DNA Viral Load Predicts Risk of Distant Metastasis in Patients with HPV16-Positive Oropharyngeal Cancer Open
Background: There are definite reasons to implement molecular diagnostics based on the measurement of human papillomavirus (HPV) DNA in liquid biopsy into clinical practice. It is a quick, repeatable, and health-safe test for cancer biomar…
View article: Determinants of the level of circulating-tumor HPV16 DNA in patients with HPV-associated oropharyngeal cancer at the time of diagnosis
Determinants of the level of circulating-tumor HPV16 DNA in patients with HPV-associated oropharyngeal cancer at the time of diagnosis Open
View article: DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients
DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients Open
Radiotherapy and cisplatin-based chemotherapy belong to the main treatment modalities for head and neck squamous cell carcinoma (HNSCC) and induce cancer cell death by generating DNA damage, including the most severe double-strand breaks (…
View article: 933P Real-world patterns of immunotherapy utilization and outcomes in recurrent/metastatic head and neck cancer (R/M HNC) patients across European countries: A multicenter retrospective federated analysis
933P Real-world patterns of immunotherapy utilization and outcomes in recurrent/metastatic head and neck cancer (R/M HNC) patients across European countries: A multicenter retrospective federated analysis Open
View article: DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients
DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients Open
Radiotherapy and cisplatin-based chemotherapy belong to the main treatment modalities for head and neck squamous cell carcinoma (HNSCC), and induce cancer cell death by generating DNA damage, including the most severe double strand breaks …
View article: Dermoscopy of acute radiation-induced dermatitis in patients with head and neck cancers treated with radiotherapy
Dermoscopy of acute radiation-induced dermatitis in patients with head and neck cancers treated with radiotherapy Open
View article: Influence of nutritional counseling on treatment results in patients with head and neck cancers
Influence of nutritional counseling on treatment results in patients with head and neck cancers Open
Patients with HNC who received NC during radical treatment experienced reduced weight loss. This effect was particularly pronounced in patients with oral cavity or oropharyngeal cancer and those undergoing chemotherapy. Additionally, NC wa…
View article: Magnetic resonance imaging in patients with cardiac implantable electronic devices in a cardio-oncology center
Magnetic resonance imaging in patients with cardiac implantable electronic devices in a cardio-oncology center Open
View article: Low-Dose Radiotherapy for Patients with Pneumonia Due to COVID-19: A Single-Institution Prospective Study
Low-Dose Radiotherapy for Patients with Pneumonia Due to COVID-19: A Single-Institution Prospective Study Open
Purpose: Results of the low-dose radiation therapy (LDRT) in patients with pneumonia due to COVID-19 has been presented. Methods: Fifteen patients received a single-fraction radiation dose of 1 Gy to the bilateral lungs due to pre-ARDS pne…
View article: Results of Primary Treatment and Salvage Treatment in the Management of Patients with Non-Squamous Cell Malignant Tumors of the Sinonasal Region: Single Institution Experience
Results of Primary Treatment and Salvage Treatment in the Management of Patients with Non-Squamous Cell Malignant Tumors of the Sinonasal Region: Single Institution Experience Open
Non-squamous cell carcinoma-related malignant sinonasal tract tumors (non-SCC MSTT) are rare and diverse malignancies. In this study, we report our experience in the management of this group of patients. The treatment outcome has been pres…
View article: Practical Application of Circulating Tumor-Related DNA of Human Papillomavirus in Liquid Biopsy to Evaluate the Molecular Response in Patients with Oropharyngeal Cancer
Practical Application of Circulating Tumor-Related DNA of Human Papillomavirus in Liquid Biopsy to Evaluate the Molecular Response in Patients with Oropharyngeal Cancer Open
Recent findings have shown that human papillomavirus (HPV) DNA is present in the blood as a tumor-specific biomarker (circulating tumor-related HPV; ctHPV) in patients with HPV-related oropharyngeal cancer (HPV-related OPC). The molecular …
View article: Circulating HPV16 DNA in Blood Plasma as Prognosticator and Early Indicator of Cancer Recurrence in Radio-Chemotherapy for Anal Cancer
Circulating HPV16 DNA in Blood Plasma as Prognosticator and Early Indicator of Cancer Recurrence in Radio-Chemotherapy for Anal Cancer Open
Background: Implementation of anal squamous cell carcinoma (ASCC) treatment modifications requires reliable patient risk stratification. The circulating tumor–related human papillomavirus type 16 (ctHPV16) may play a role in predicting sur…
View article: Safety and Feasibility of Radiation Therapy Combined with CDK 4/6 Inhibitors in the Management of Advanced Breast Cancer
Safety and Feasibility of Radiation Therapy Combined with CDK 4/6 Inhibitors in the Management of Advanced Breast Cancer Open
The addition of CDK4/6 inhibitors to endocrine therapy in advanced hormone receptor-positive HER2-negative breast cancer has led to practice-changing improvements in overall survival. However, data concerning the safety of CDK4/6i combinat…
View article: 703TiP A randomised, double-blind, placebo-controlled phase II study of setanaxib plus pembrolizumab for the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (rmSCCHN)
703TiP A randomised, double-blind, placebo-controlled phase II study of setanaxib plus pembrolizumab for the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (rmSCCHN) Open